Advanced

CSF/serum albumin ratio in dementias : a cross-sectional study on 1861 patients

Skillbäck, Tobias; Delsing, Louise; Synnergren, Jane; Mattsson, Niklas LU ; Janelidze, Shorena LU ; Nägga, Katarina LU ; Kilander, Lena; Hicks, Ryan; Wimo, Anders and Winblad, Bengt, et al. (2017) In Neurobiology of Aging 59. p.1-9
Abstract

A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362), Lewy body dementia (DLB, n = 50), frontotemporal dementia (FTD, n = 56), Parkinson's disease dementia (PDD, n = 23), other dementias (other, n = 48), and dementia not otherwise specified (NOS, n = 271). We compared CSF/serum albumin ratio to 2 healthy control groups (n = 292, n = 20), between dementia diagnoses, and tested biomarker... (More)

A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362), Lewy body dementia (DLB, n = 50), frontotemporal dementia (FTD, n = 56), Parkinson's disease dementia (PDD, n = 23), other dementias (other, n = 48), and dementia not otherwise specified (NOS, n = 271). We compared CSF/serum albumin ratio to 2 healthy control groups (n = 292, n = 20), between dementia diagnoses, and tested biomarker associations. Patients in DLB, LAD, VaD, MIX, other, and NOS groups had higher CSF/serum albumin ratio than controls. CSF/serum albumin ratio correlated with CSF neurofilament light in LAD, MIX, VaD, and other groups but not with AD biomarkers. Our data show that BBB leakage is common in dementias. The lack of association between CSF/serum albumin ratio and AD biomarkers suggests that BBB dysfunction is not inherent to AD but might represent concomitant cerebrovascular pathology.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Blood-brain barrier, CSF/serum albumin ratio, Dementia
in
Neurobiology of Aging
volume
59
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85026625803
  • wos:000411446800001
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2017.06.028
language
English
LU publication?
yes
id
a0deb5cb-7936-489d-a4b2-ac5055732228
date added to LUP
2017-08-22 15:47:23
date last changed
2018-10-03 10:47:09
@article{a0deb5cb-7936-489d-a4b2-ac5055732228,
  abstract     = {<p>A connection between dementias and blood-brain barrier (BBB) dysfunction has been suggested, but previous studies have yielded conflicting results. We examined cerebrospinal fluid (CSF)/serum albumin ratio in a large cohort of patients diagnosed with Alzheimer's disease (AD, early onset [EAD, n = 130], late onset AD [LAD, n = 666]), vascular dementia (VaD, n = 255), mixed AD and VaD (MIX, n = 362), Lewy body dementia (DLB, n = 50), frontotemporal dementia (FTD, n = 56), Parkinson's disease dementia (PDD, n = 23), other dementias (other, n = 48), and dementia not otherwise specified (NOS, n = 271). We compared CSF/serum albumin ratio to 2 healthy control groups (n = 292, n = 20), between dementia diagnoses, and tested biomarker associations. Patients in DLB, LAD, VaD, MIX, other, and NOS groups had higher CSF/serum albumin ratio than controls. CSF/serum albumin ratio correlated with CSF neurofilament light in LAD, MIX, VaD, and other groups but not with AD biomarkers. Our data show that BBB leakage is common in dementias. The lack of association between CSF/serum albumin ratio and AD biomarkers suggests that BBB dysfunction is not inherent to AD but might represent concomitant cerebrovascular pathology.</p>},
  author       = {Skillbäck, Tobias and Delsing, Louise and Synnergren, Jane and Mattsson, Niklas and Janelidze, Shorena and Nägga, Katarina and Kilander, Lena and Hicks, Ryan and Wimo, Anders and Winblad, Bengt and Hansson, Oskar and Blennow, Kaj and Eriksdotter, Maria and Zetterberg, Henrik},
  issn         = {0197-4580},
  keyword      = {Alzheimer's disease,Blood-brain barrier,CSF/serum albumin ratio,Dementia},
  language     = {eng},
  month        = {11},
  pages        = {1--9},
  publisher    = {Elsevier},
  series       = {Neurobiology of Aging},
  title        = {CSF/serum albumin ratio in dementias : a cross-sectional study on 1861 patients},
  url          = {http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.028},
  volume       = {59},
  year         = {2017},
}