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Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management : A substudy of the targeted temperature management trial

Harmon, Matthew B.A.; van Meenen, David M.P.; van der Veen, Annelou L.I.P.; Binnekade, Jan M.; Dankiewicz, Josef LU ; Ebner, Florian LU ; Nielsen, Niklas LU ; Pelosi, Paolo; Schultz, Marcus J. and Horn, Janneke, et al. (2018) In Resuscitation 129. p.29-36
Abstract

Aims: Mechanical ventilation practices in patients with cardiac arrest are not well described. Also, the effect of temperature on mechanical ventilation settings is not known. The aims of this study were 1) to describe practice of mechanical ventilation and its relation with outcome 2) to determine effects of different target temperatures strategies (33 °C versus 36 °C) on mechanical ventilation settings. Methods: This is a substudy of the TTM-trial in which unconscious survivors of a cardiac arrest due to a cardiac cause were randomized to two TTM strategies, 33 °C (TTM33) and 36 °C (TTM36). Mechanical ventilation data were obtained at three time points: 1) before TTM; 2) at the end of TTM (before rewarming) and 3) after rewarming.... (More)

Aims: Mechanical ventilation practices in patients with cardiac arrest are not well described. Also, the effect of temperature on mechanical ventilation settings is not known. The aims of this study were 1) to describe practice of mechanical ventilation and its relation with outcome 2) to determine effects of different target temperatures strategies (33 °C versus 36 °C) on mechanical ventilation settings. Methods: This is a substudy of the TTM-trial in which unconscious survivors of a cardiac arrest due to a cardiac cause were randomized to two TTM strategies, 33 °C (TTM33) and 36 °C (TTM36). Mechanical ventilation data were obtained at three time points: 1) before TTM; 2) at the end of TTM (before rewarming) and 3) after rewarming. Logistic regression was used to determine an association between mechanical ventilation variables and outcome. Repeated-measures mixed modelling was performed to determine the effect of TTM on ventilation settings. Results: Mechanical ventilation data was available for 567 of the 950 TTM patients. Of these, 81% was male with a mean (SD) age of 64 (12) years. At the end of TTM median tidal volume was 7.7 ml/kg predicted body weight (PBW)(6.4–8.7) and 60% of patients were ventilated with a tidal volume ≤ 8 ml/kg PBW. Median PEEP was 7.7cmH2O (6.4–8.7) and mean driving pressure was 14.6 cmH2O (±4.3). The median FiO2 fraction was 0.35 (0.30–0.45). Multivariate analysis showed an independent relationship between increased respiratory rate and 28-day mortality. TTM33 resulted in lower end-tidal CO2 (Pgroup = 0.0003) and higher alveolar dead space fraction (Pgroup = 0.003) compared to TTM36, while PCO2 levels and respiratory minute volume were similar between groups. Conclusions: In the majority of the cardiac arrest patients, protective ventilation settings are applied, including low tidal volumes and driving pressures. High respiratory rate was associated with mortality. TTM33 results in lower end-tidal CO2 levels and a higher alveolar dead space fraction compared to TTTM36.

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published
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keywords
Mechanical ventilation, Post cardiac arrest, Target temperature management
in
Resuscitation
volume
129
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:85047798089
ISSN
0300-9572
DOI
language
English
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yes
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a0ea3ab6-ce02-4953-a765-8ffeadc065aa
date added to LUP
2018-06-11 11:13:05
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2018-06-12 03:00:03
@article{a0ea3ab6-ce02-4953-a765-8ffeadc065aa,
  abstract     = {<p>Aims: Mechanical ventilation practices in patients with cardiac arrest are not well described. Also, the effect of temperature on mechanical ventilation settings is not known. The aims of this study were 1) to describe practice of mechanical ventilation and its relation with outcome 2) to determine effects of different target temperatures strategies (33 °C versus 36 °C) on mechanical ventilation settings. Methods: This is a substudy of the TTM-trial in which unconscious survivors of a cardiac arrest due to a cardiac cause were randomized to two TTM strategies, 33 °C (TTM33) and 36 °C (TTM36). Mechanical ventilation data were obtained at three time points: 1) before TTM; 2) at the end of TTM (before rewarming) and 3) after rewarming. Logistic regression was used to determine an association between mechanical ventilation variables and outcome. Repeated-measures mixed modelling was performed to determine the effect of TTM on ventilation settings. Results: Mechanical ventilation data was available for 567 of the 950 TTM patients. Of these, 81% was male with a mean (SD) age of 64 (12) years. At the end of TTM median tidal volume was 7.7 ml/kg predicted body weight (PBW)(6.4–8.7) and 60% of patients were ventilated with a tidal volume ≤ 8 ml/kg PBW. Median PEEP was 7.7cmH<sub>2</sub>O (6.4–8.7) and mean driving pressure was 14.6 cmH<sub>2</sub>O (±4.3). The median FiO<sub>2</sub> fraction was 0.35 (0.30–0.45). Multivariate analysis showed an independent relationship between increased respiratory rate and 28-day mortality. TTM33 resulted in lower end-tidal CO<sub>2</sub> (Pgroup = 0.0003) and higher alveolar dead space fraction (Pgroup = 0.003) compared to TTM36, while PCO<sub>2</sub> levels and respiratory minute volume were similar between groups. Conclusions: In the majority of the cardiac arrest patients, protective ventilation settings are applied, including low tidal volumes and driving pressures. High respiratory rate was associated with mortality. TTM33 results in lower end-tidal CO<sub>2</sub> levels and a higher alveolar dead space fraction compared to TTTM36.</p>},
  author       = {Harmon, Matthew B.A. and van Meenen, David M.P. and van der Veen, Annelou L.I.P. and Binnekade, Jan M. and Dankiewicz, Josef and Ebner, Florian and Nielsen, Niklas and Pelosi, Paolo and Schultz, Marcus J. and Horn, Janneke and Friberg, Hans and Juffermans, Nicole P. and , },
  issn         = {0300-9572},
  keyword      = {Mechanical ventilation,Post cardiac arrest,Target temperature management},
  language     = {eng},
  month        = {08},
  pages        = {29--36},
  publisher    = {Elsevier},
  series       = {Resuscitation},
  title        = {Practice of mechanical ventilation in cardiac arrest patients and effects of targeted temperature management : A substudy of the targeted temperature management trial},
  url          = {http://dx.doi.org/},
  volume       = {129},
  year         = {2018},
}