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Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory comparisons

Ainsbury, Elizabeth; Badie, Christophe; Barnard, Stephen; Manning, Grainne; Moquet, Jayne; Abend, Michael; Bassinet, Celine; Bortolin, Emanuela; Bossin, Lily and Bricknell, Clare, et al. (2017) In International Journal of Radiation Biology 93(1). p.99-109
Abstract

Purpose: RENEB, ‘Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,’ is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and... (More)

Purpose: RENEB, ‘Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,’ is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation-induced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.

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publication status
published
subject
keywords
Biodosimetry, physical retrospective dosimetry, radiation accidents, RENEB
in
International Journal of Radiation Biology
volume
93
issue
1
pages
99 - 109
publisher
Taylor & Francis
external identifiers
  • Scopus:84979082160
ISSN
0955-3002
DOI
10.1080/09553002.2016.1206233
language
English
LU publication?
yes
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a11b1346-6dec-4fc1-84a0-8bfa1b6882f2
date added to LUP
2016-08-15 15:53:18
date last changed
2017-02-02 08:10:20
@article{a11b1346-6dec-4fc1-84a0-8bfa1b6882f2,
  abstract     = {<p>Purpose: RENEB, ‘Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,’ is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There is a requirement to test and/or validate these candidate techniques and inter-comparison exercises are a well-established method for such validation. Materials and methods: The authors present details of inter-comparisons of four such new methods: dicentric chromosome analysis including telomere and centromere staining; the gene expression assay carried out in whole blood; Raman spectroscopy on blood lymphocytes, and detection of radiation-induced thermoluminescent signals in glass screens taken from mobile phones. Results: In general the results show good agreement between the laboratories and methods within the expected levels of uncertainty, and thus demonstrate that there is a lot of potential for each of the candidate techniques. Conclusions: Further work is required before the new methods can be included within the suite of reliable dosimetry methods for use by RENEB partners and others in routine and emergency response scenarios.</p>},
  author       = {Ainsbury, Elizabeth and Badie, Christophe and Barnard, Stephen and Manning, Grainne and Moquet, Jayne and Abend, Michael and Bassinet, Celine and Bortolin, Emanuela and Bossin, Lily and Bricknell, Clare and Brzoska, Kamil and Čemusová, Zina and Christiansson, Maria and Cosler, Guillaume and Della Monaca, Sara and Desangles, François and Discher, Michael and Doucha-Senf, Sven and Eakins, Jon and Fattibene, Paola and Gregoire, Eric and Guogyte, Kamile and Kriehuber, Ralf and Lee, Jungil and Lloyd, David and Lyng, Fiona and Macaeva, Ellina and Majewski, Matthaeus and McKeever, Stephen W S and Meade, Aidan and M’kacher, Radhia and Medipally, Dinesh and Oestreicher, Ursula and Oskamp, Dominik and Pateux, Jerome and Port, Matthias and Quattrini, Maria Cristina and Quintens, Roel and Ricoul, Michelle and Roy, Laurence and Sabatier, Laure and Sholom, Sergey and Strunz, Sonja and Trompier, Francois and Valente, Marco and Van Hoey, Olivier and Veronese, Ivan and Wojcik, Andrzej and Woda, Clemens},
  issn         = {0955-3002},
  keyword      = {Biodosimetry,physical retrospective dosimetry,radiation accidents,RENEB},
  language     = {eng},
  number       = {1},
  pages        = {99--109},
  publisher    = {Taylor & Francis},
  series       = {International Journal of Radiation Biology},
  title        = {Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory comparisons},
  url          = {http://dx.doi.org/10.1080/09553002.2016.1206233},
  volume       = {93},
  year         = {2017},
}