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Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study

, ; van Dijk, D.; Balkau, B.; Segrestin, B.; Gottsäter, M. LU ; Gabriel, R.; Hatunic, M.; Mari, A.; Dekker, J. M. and Rutters, F. (2019) In Diabetes and Metabolism 45(4). p.375-381
Abstract

Aim: Extremes in sleep duration play an important role in the development of type 2 diabetes. We examined the associations between sleep duration and sleep debt with estimates of insulin sensitivity and insulin secretion. Methods: Data were derived from the European multi-centre EGIR-RISC study. Sleep duration and sleep debt were derived from a sleep questionnaire asking about sleeping time during the week and during the weekend. Insulin sensitivity and insulin secretion were estimated from a 2-hour Oral Glucose Tolerance Test, with samples every 30 minutes. Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion, were analysed by multiple linear regression models corrected for possible... (More)

Aim: Extremes in sleep duration play an important role in the development of type 2 diabetes. We examined the associations between sleep duration and sleep debt with estimates of insulin sensitivity and insulin secretion. Methods: Data were derived from the European multi-centre EGIR-RISC study. Sleep duration and sleep debt were derived from a sleep questionnaire asking about sleeping time during the week and during the weekend. Insulin sensitivity and insulin secretion were estimated from a 2-hour Oral Glucose Tolerance Test, with samples every 30 minutes. Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion, were analysed by multiple linear regression models corrected for possible confounders. Results: Sleep data were available in 1002 participants, 46% men, mean age 48 ± 8 years, who had an average sleep duration of 7 ± 1 hours [range 3–14] and an average sleep debt (absolute difference hours sleep weekend days minus weekdays) of 1 ± 1 hour [range 0–8]. With regard to insulin sensitivity, we observed an inverted U-shaped association between sleep duration and the Stumvoll MCR in (mL/kg/min), with a corrected β (95% CI) of 2.05 (0.8; 3.3) and for the quadratic term −0.2 (−0.3; −0.1). Similarly, a U-shaped association between sleep duration and log HOMA-IR in (µU/mL), with a corrected βs of −0.83 (−1.4; −0.24) and 0.06 (0.02; 0.10) for the quadratic term. Confounders showed an attenuating effect on the associations, while BMI mediated 60 to 91% of the association between sleep duration and insulin sensitivity. No significant associations were observed between sleep duration with insulin secretion or between sleep debt with either insulin sensitivity or insulin secretion. Conclusions: Short and long sleep duration are associated with a lower insulin sensitivity, suggesting that sleep plays an important role in insulin resistance and may provide the link with development of type 2 diabetes.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Duration, Insulin resistance, Insulin sensitivity, Sleep, Variability
in
Diabetes and Metabolism
volume
45
issue
4
pages
375 - 381
publisher
Masson Editeur
external identifiers
  • scopus:85057045700
ISSN
1262-3636
DOI
10.1016/j.diabet.2018.11.001
language
English
LU publication?
yes
id
a11d90b3-578b-4ac1-8326-27b714f2b349
date added to LUP
2018-12-04 14:11:52
date last changed
2019-10-15 06:52:07
@article{a11d90b3-578b-4ac1-8326-27b714f2b349,
  abstract     = {<p>Aim: Extremes in sleep duration play an important role in the development of type 2 diabetes. We examined the associations between sleep duration and sleep debt with estimates of insulin sensitivity and insulin secretion. Methods: Data were derived from the European multi-centre EGIR-RISC study. Sleep duration and sleep debt were derived from a sleep questionnaire asking about sleeping time during the week and during the weekend. Insulin sensitivity and insulin secretion were estimated from a 2-hour Oral Glucose Tolerance Test, with samples every 30 minutes. Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion, were analysed by multiple linear regression models corrected for possible confounders. Results: Sleep data were available in 1002 participants, 46% men, mean age 48 ± 8 years, who had an average sleep duration of 7 ± 1 hours [range 3–14] and an average sleep debt (absolute difference hours sleep weekend days minus weekdays) of 1 ± 1 hour [range 0–8]. With regard to insulin sensitivity, we observed an inverted U-shaped association between sleep duration and the Stumvoll MCR in (mL/kg/min), with a corrected β (95% CI) of 2.05 (0.8; 3.3) and for the quadratic term −0.2 (−0.3; −0.1). Similarly, a U-shaped association between sleep duration and log HOMA-IR in (µU/mL), with a corrected βs of −0.83 (−1.4; −0.24) and 0.06 (0.02; 0.10) for the quadratic term. Confounders showed an attenuating effect on the associations, while BMI mediated 60 to 91% of the association between sleep duration and insulin sensitivity. No significant associations were observed between sleep duration with insulin secretion or between sleep debt with either insulin sensitivity or insulin secretion. Conclusions: Short and long sleep duration are associated with a lower insulin sensitivity, suggesting that sleep plays an important role in insulin resistance and may provide the link with development of type 2 diabetes.</p>},
  author       = {,  and van Dijk, D. and Balkau, B. and Segrestin, B. and Gottsäter, M. and Gabriel, R. and Hatunic, M. and Mari, A. and Dekker, J. M. and Rutters, F.},
  issn         = {1262-3636},
  keyword      = {Duration,Insulin resistance,Insulin sensitivity,Sleep,Variability},
  language     = {eng},
  number       = {4},
  pages        = {375--381},
  publisher    = {Masson Editeur},
  series       = {Diabetes and Metabolism},
  title        = {Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study},
  url          = {http://dx.doi.org/10.1016/j.diabet.2018.11.001},
  volume       = {45},
  year         = {2019},
}