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An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia : a multi-center study of 381 patients

Nahi, Hareth ; Hägglund, Hans ; Ahlgren, Thomas ; Bernell, Per ; Hardling, Mats ; Karlsson, Karin LU ; Lazarevic, Vladimir Lj LU orcid ; Linderholm, Mats ; Smedmyr, Bengt and Aström, Maria , et al. (2008) In Haematologica 93(11). p.8-1734
Abstract

In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with... (More)

In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.

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publication status
published
subject
keywords
Adolescent, Adult, Aged, Burkitt Lymphoma, Chromosome Mapping, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 22, Chromosomes, Human, Pair 9, Genetic Markers, Humans, Karyotyping, Leukocyte Count, Middle Aged, Prognosis, Sequence Deletion, Survival Analysis, Translocation, Genetic, World Health Organization
in
Haematologica
volume
93
issue
11
pages
5 pages
publisher
Ferrata Storti Foundation
external identifiers
  • pmid:18728022
  • scopus:55549115330
ISSN
1592-8721
DOI
10.3324/haematol.13227
language
English
LU publication?
yes
id
a125c62e-84e3-493d-9d24-57fe8de883cd
date added to LUP
2016-05-24 17:18:06
date last changed
2025-01-12 03:05:29
@article{a125c62e-84e3-493d-9d24-57fe8de883cd,
  abstract     = {{<p>In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.</p>}},
  author       = {{Nahi, Hareth and Hägglund, Hans and Ahlgren, Thomas and Bernell, Per and Hardling, Mats and Karlsson, Karin and Lazarevic, Vladimir Lj and Linderholm, Mats and Smedmyr, Bengt and Aström, Maria and Hallböök, Helene}},
  issn         = {{1592-8721}},
  keywords     = {{Adolescent; Adult; Aged; Burkitt Lymphoma; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 9; Genetic Markers; Humans; Karyotyping; Leukocyte Count; Middle Aged; Prognosis; Sequence Deletion; Survival Analysis; Translocation, Genetic; World Health Organization}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{8--1734}},
  publisher    = {{Ferrata Storti Foundation}},
  series       = {{Haematologica}},
  title        = {{An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia : a multi-center study of 381 patients}},
  url          = {{http://dx.doi.org/10.3324/haematol.13227}},
  doi          = {{10.3324/haematol.13227}},
  volume       = {{93}},
  year         = {{2008}},
}