Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study

Baldanzi, Gabriel ; Sayols-Baixeras, Sergi ; Theorell-Haglöw, Jenny ; Dekkers, Koen F. ; Hammar, Ulf ; Nguyen, Diem ; Lin, Yi Ting ; Ahmad, Shafqat ; Holm, Jacob Bak and Nielsen, Henrik Bjørn , et al. (2023) In Chest 164(2). p.503-516
Abstract

Background: OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism. Research Question: Does OSA in adults associate with the composition and functional potential of the human gut microbiota? Study Design and Methods: We used respiratory polygraphy data from up to 3,570 individuals 50 to 64 years of age from the population-based Swedish Cardiopulmonary bioimage Study combined with deep shotgun metagenomics of fecal samples to... (More)

Background: OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism. Research Question: Does OSA in adults associate with the composition and functional potential of the human gut microbiota? Study Design and Methods: We used respiratory polygraphy data from up to 3,570 individuals 50 to 64 years of age from the population-based Swedish Cardiopulmonary bioimage Study combined with deep shotgun metagenomics of fecal samples to identify cross-sectional associations between three OSA parameters covering apneas and hypopneas, cumulative sleep time in hypoxia, and number of oxygen desaturation events with gut microbiota composition. Data collection about potential confounders was based on questionnaires, onsite anthropometric measurements, plasma metabolomics, and linkage with the Swedish Prescribed Drug Register. Results: We found that all three OSA parameters were associated with lower diversity of species in the gut. Furthermore, in multivariable-adjusted analysis, the OSA-related hypoxia parameters were associated with the relative abundance of 128 gut bacterial species, including higher abundance of Blautia obeum and Collinsella aerofaciens. The latter species was also independently associated with increased systolic BP. Furthermore, the cumulative time in hypoxia during sleep was associated with the abundance of genes involved in nine gut microbiota metabolic pathways, including propionate production from lactate. Finally, we observed two heterogeneous sets of plasma metabolites with opposite association with species positively and negatively associated with hypoxia parameters, respectively. Interpretation: OSA-related hypoxia, but not the number of apneas/hypopneas, is associated with specific gut microbiota species and functions. Our findings lay the foundation for future research on the gut microbiota-mediated health effects of OSA.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
epidemiology, microbiota, OSA
in
Chest
volume
164
issue
2
pages
14 pages
publisher
American College of Chest Physicians
external identifiers
  • pmid:36925044
  • scopus:85156160279
ISSN
0012-3692
DOI
10.1016/j.chest.2023.03.010
language
English
LU publication?
yes
id
a13068b8-cb2b-4789-808b-e6d647b6ca0f
date added to LUP
2024-01-12 15:21:14
date last changed
2024-04-27 10:42:00
@article{a13068b8-cb2b-4789-808b-e6d647b6ca0f,
  abstract     = {{<p>Background: OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism. Research Question: Does OSA in adults associate with the composition and functional potential of the human gut microbiota? Study Design and Methods: We used respiratory polygraphy data from up to 3,570 individuals 50 to 64 years of age from the population-based Swedish Cardiopulmonary bioimage Study combined with deep shotgun metagenomics of fecal samples to identify cross-sectional associations between three OSA parameters covering apneas and hypopneas, cumulative sleep time in hypoxia, and number of oxygen desaturation events with gut microbiota composition. Data collection about potential confounders was based on questionnaires, onsite anthropometric measurements, plasma metabolomics, and linkage with the Swedish Prescribed Drug Register. Results: We found that all three OSA parameters were associated with lower diversity of species in the gut. Furthermore, in multivariable-adjusted analysis, the OSA-related hypoxia parameters were associated with the relative abundance of 128 gut bacterial species, including higher abundance of Blautia obeum and Collinsella aerofaciens. The latter species was also independently associated with increased systolic BP. Furthermore, the cumulative time in hypoxia during sleep was associated with the abundance of genes involved in nine gut microbiota metabolic pathways, including propionate production from lactate. Finally, we observed two heterogeneous sets of plasma metabolites with opposite association with species positively and negatively associated with hypoxia parameters, respectively. Interpretation: OSA-related hypoxia, but not the number of apneas/hypopneas, is associated with specific gut microbiota species and functions. Our findings lay the foundation for future research on the gut microbiota-mediated health effects of OSA.</p>}},
  author       = {{Baldanzi, Gabriel and Sayols-Baixeras, Sergi and Theorell-Haglöw, Jenny and Dekkers, Koen F. and Hammar, Ulf and Nguyen, Diem and Lin, Yi Ting and Ahmad, Shafqat and Holm, Jacob Bak and Nielsen, Henrik Bjørn and Brunkwall, Louise and Benedict, Christian and Cedernaes, Jonathan and Koskiniemi, Sanna and Phillipson, Mia and Lind, Lars and Sundström, Johan and Bergström, Göran and Engström, Gunnar and Smith, J. Gustav and Orho-Melander, Marju and Ärnlöv, Johan and Kennedy, Beatrice and Lindberg, Eva and Fall, Tove}},
  issn         = {{0012-3692}},
  keywords     = {{epidemiology; microbiota; OSA}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{503--516}},
  publisher    = {{American College of Chest Physicians}},
  series       = {{Chest}},
  title        = {{OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study}},
  url          = {{http://dx.doi.org/10.1016/j.chest.2023.03.010}},
  doi          = {{10.1016/j.chest.2023.03.010}},
  volume       = {{164}},
  year         = {{2023}},
}