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Dysphagia - Results from multivariable predictive modelling on aspiration from a subset of the ARTSCAN trial

Söderström, Karin; Nilsson, Per LU ; Laurell, Göran; Zackrisson, Björn and Jäghagen, Eva Levring (2017) In Radiotherapy and Oncology 122(2). p.192-199
Abstract

Purpose: To establish predictive models for late objective aspiration and late patient-reported choking based on dose-volume parameters and baseline patient and treatment characteristics, for patients with head and neck cancer undergoing definitive radiotherapy (RT). The impact of electively treated volume on late aspiration was also investigated. Methods and material: This prospective cohort is a subsample of 124 survivors from the ARTSCAN study. Late aspiration was identified with videofluoroscopy, at a minimum of 25. months after the start of RT. Patient-reported choking was analysed at 12 and 60. months post RT using the EORTC Quality of Life Module for Head and Neck Cancer 35. Univariable and multivariable analyses were performed... (More)

Purpose: To establish predictive models for late objective aspiration and late patient-reported choking based on dose-volume parameters and baseline patient and treatment characteristics, for patients with head and neck cancer undergoing definitive radiotherapy (RT). The impact of electively treated volume on late aspiration was also investigated. Methods and material: This prospective cohort is a subsample of 124 survivors from the ARTSCAN study. Late aspiration was identified with videofluoroscopy, at a minimum of 25. months after the start of RT. Patient-reported choking was analysed at 12 and 60. months post RT using the EORTC Quality of Life Module for Head and Neck Cancer 35. Univariable and multivariable analyses were performed to describe the association between clinical factors and dose-volume descriptors for organs at risk (OARs) and late dysphagia. Results: Aspiration was found in 47% of the eligible patients. Mean dose to the middle pharyngeal constrictor (MPC), neck dissection post RT and age at randomisation in ARTSCAN were associated to late aspiration. Mean dose to the superior pharyngeal constrictor (SPC) and swallowing complaints at baseline were associated to patient reported choking at both time-points. Conclusions: Three separate risk groups for late aspiration, and two risk groups for late patient-reported choking were identified based on number of risk factors. The size of the electively treated volume could be used as a surrogate for individual OARs predicting late aspiration.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dysphagia, Head and neck cancer, Normal tissue complication probability, Radiotherapy
in
Radiotherapy and Oncology
volume
122
issue
2
pages
192 - 199
publisher
Elsevier
external identifiers
  • scopus:84995615075
  • wos:000395607300004
ISSN
0167-8140
DOI
10.1016/j.radonc.2016.09.001
language
English
LU publication?
yes
id
a17e3aca-97e1-4696-88a0-953c4e452cae
date added to LUP
2016-12-02 12:22:34
date last changed
2018-04-08 04:51:22
@article{a17e3aca-97e1-4696-88a0-953c4e452cae,
  abstract     = {<p>Purpose: To establish predictive models for late objective aspiration and late patient-reported choking based on dose-volume parameters and baseline patient and treatment characteristics, for patients with head and neck cancer undergoing definitive radiotherapy (RT). The impact of electively treated volume on late aspiration was also investigated. Methods and material: This prospective cohort is a subsample of 124 survivors from the ARTSCAN study. Late aspiration was identified with videofluoroscopy, at a minimum of 25. months after the start of RT. Patient-reported choking was analysed at 12 and 60. months post RT using the EORTC Quality of Life Module for Head and Neck Cancer 35. Univariable and multivariable analyses were performed to describe the association between clinical factors and dose-volume descriptors for organs at risk (OARs) and late dysphagia. Results: Aspiration was found in 47% of the eligible patients. Mean dose to the middle pharyngeal constrictor (MPC), neck dissection post RT and age at randomisation in ARTSCAN were associated to late aspiration. Mean dose to the superior pharyngeal constrictor (SPC) and swallowing complaints at baseline were associated to patient reported choking at both time-points. Conclusions: Three separate risk groups for late aspiration, and two risk groups for late patient-reported choking were identified based on number of risk factors. The size of the electively treated volume could be used as a surrogate for individual OARs predicting late aspiration.</p>},
  author       = {Söderström, Karin and Nilsson, Per and Laurell, Göran and Zackrisson, Björn and Jäghagen, Eva Levring},
  issn         = {0167-8140},
  keyword      = {Dysphagia,Head and neck cancer,Normal tissue complication probability,Radiotherapy},
  language     = {eng},
  number       = {2},
  pages        = {192--199},
  publisher    = {Elsevier},
  series       = {Radiotherapy and Oncology},
  title        = {Dysphagia - Results from multivariable predictive modelling on aspiration from a subset of the ARTSCAN trial},
  url          = {http://dx.doi.org/10.1016/j.radonc.2016.09.001},
  volume       = {122},
  year         = {2017},
}