Flat and depressed colorectal tumours in a southern Swedish population: a prospective chromoendoscopic and histopathological study.0
(2002) In Gut 51(4). p.550-555- Abstract
- Background: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries.
Aims: To study the occurrence of flat colorectal tumours in a southern Swedish population.
Methods: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was determined by histopathological examination.
Results: A total of 973 tumours were found; 907 (93.2%) were protruding and 66 (6.8%) were flat or depressed. Of the flat/depressed tumours, five (7.7%) were early adenocarcinomas infiltrating the submucosa. Eleven carcinomas (1.2%) were found... (More) - Background: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries.
Aims: To study the occurrence of flat colorectal tumours in a southern Swedish population.
Methods: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was determined by histopathological examination.
Results: A total of 973 tumours were found; 907 (93.2%) were protruding and 66 (6.8%) were flat or depressed. Of the flat/depressed tumours, five (7.7%) were early adenocarcinomas infiltrating the submucosa. Eleven carcinomas (1.2%) were found among protruding tumours. High grade dysplasia was observed in 18% (n=11) of flat/depressed adenomas in contrast with 7.3% (n=65) of protruding adenomas, and occurred in smaller flat/depressed tumours compared with protruding ones (mean diameter 8 mm v 23 mm, respectively). Furthermore, high grade dysplasia was significantly more common in flat elevated tumours with central depression or in depressed adenomas (35.7%; 5/14) than in flat elevated adenomas (12.8%; 6/47).
Conclusion: Flat and depressed tumours exist in a Western population. Future studies should address whether or not chromoendoscopy with video colonoscopy is necessary in the search for flat colorectal neoplasms. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/114867
- author
- Tsuda, S ; Veress, Bela LU ; Tóth, E and Fork, Thomas LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Prospective Studies, Middle Age, Male, Human, Sweden: epidemiology, Support, Non-U.S. Gov't, Endoscopy, Adenoma: epidemiology, Adenoma: pathology, Adult, Aged, Colorectal Neoplasms: pathology, Carcinoma: pathology, Colorectal Neoplasms: epidemiology, Gastrointestinal: methods, Female, 80 and over, Carcinoma: epidemiology
- in
- Gut
- volume
- 51
- issue
- 4
- pages
- 550 - 555
- publisher
- BMJ Publishing Group
- external identifiers
-
- wos:000178243600020
- pmid:12235079
- scopus:0036785362
- ISSN
- 1468-3288
- DOI
- 10.1136/gut.51.4.550
- language
- English
- LU publication?
- yes
- id
- a191737e-4984-4d77-b449-3f34b0bd434a (old id 114867)
- alternative location
- http://gut.bmjjournals.com/cgi/reprint/51/4/550.pdf
- date added to LUP
- 2016-04-01 16:44:42
- date last changed
- 2022-03-15 02:39:02
@article{a191737e-4984-4d77-b449-3f34b0bd434a,
abstract = {{Background: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries.<br/><br>
<br/><br>
Aims: To study the occurrence of flat colorectal tumours in a southern Swedish population.<br/><br>
<br/><br>
Methods: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was determined by histopathological examination.<br/><br>
<br/><br>
Results: A total of 973 tumours were found; 907 (93.2%) were protruding and 66 (6.8%) were flat or depressed. Of the flat/depressed tumours, five (7.7%) were early adenocarcinomas infiltrating the submucosa. Eleven carcinomas (1.2%) were found among protruding tumours. High grade dysplasia was observed in 18% (n=11) of flat/depressed adenomas in contrast with 7.3% (n=65) of protruding adenomas, and occurred in smaller flat/depressed tumours compared with protruding ones (mean diameter 8 mm v 23 mm, respectively). Furthermore, high grade dysplasia was significantly more common in flat elevated tumours with central depression or in depressed adenomas (35.7%; 5/14) than in flat elevated adenomas (12.8%; 6/47).<br/><br>
<br/><br>
Conclusion: Flat and depressed tumours exist in a Western population. Future studies should address whether or not chromoendoscopy with video colonoscopy is necessary in the search for flat colorectal neoplasms.}},
author = {{Tsuda, S and Veress, Bela and Tóth, E and Fork, Thomas}},
issn = {{1468-3288}},
keywords = {{Prospective Studies; Middle Age; Male; Human; Sweden: epidemiology; Support; Non-U.S. Gov't; Endoscopy; Adenoma: epidemiology; Adenoma: pathology; Adult; Aged; Colorectal Neoplasms: pathology; Carcinoma: pathology; Colorectal Neoplasms: epidemiology; Gastrointestinal: methods; Female; 80 and over; Carcinoma: epidemiology}},
language = {{eng}},
number = {{4}},
pages = {{550--555}},
publisher = {{BMJ Publishing Group}},
series = {{Gut}},
title = {{Flat and depressed colorectal tumours in a southern Swedish population: a prospective chromoendoscopic and histopathological study.0}},
url = {{https://lup.lub.lu.se/search/files/4767262/623785.pdf}},
doi = {{10.1136/gut.51.4.550}},
volume = {{51}},
year = {{2002}},
}