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Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

Allen, Naomi E.; Appleby, Paul N.; Key, Timothy J.; Bueno-de-Mesquita, H. B.; Ros, Martine M.; Kiemeney, Lambertus A. L. M.; Tjonneland, Anne; Roswall, Nina; Overvad, Kim and Weikert, Steffen, et al. (2013) In International Journal of Cancer 132(3). p.635-644
Abstract
Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence... (More)
Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 330%; ptrend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 367%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed. (Less)
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publication status
published
subject
keywords
nutrients, diet, bladder cancer, cohort studies, epidemiology
in
International Journal of Cancer
volume
132
issue
3
pages
635 - 644
publisher
John Wiley & Sons
external identifiers
  • wos:000311620100021
  • scopus:84870237118
ISSN
0020-7136
DOI
10.1002/ijc.27643
language
English
LU publication?
yes
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a1c9596c-c5f2-401a-b36e-c13071865e95 (old id 3401092)
date added to LUP
2013-02-01 07:06:15
date last changed
2019-01-13 03:51:03
@article{a1c9596c-c5f2-401a-b36e-c13071865e95,
  abstract     = {Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adjusted for smoking status and duration, body mass index and total energy intake. After an average of 11.3 years of follow-up, 1,416 new cases of urothelial cell carcinoma were identified. After allowing for measurement error, a 3% increase in the consumption of energy intake from animal protein was associated with a 15% higher risk (95% confidence interval [CI]: 330%; ptrend = 0.01) and a 2% increase in energy from plant protein intake was associated with a 23% lower risk (95% CI: 367%, ptrend = 0.006). Dietary intake of fat, carbohydrate, fibre or calcium was not associated with risk. These findings suggest that animal and/or plant protein may affect the risk of urothelial cell carcinoma, and examination of these associations in other studies is needed.},
  author       = {Allen, Naomi E. and Appleby, Paul N. and Key, Timothy J. and Bueno-de-Mesquita, H. B. and Ros, Martine M. and Kiemeney, Lambertus A. L. M. and Tjonneland, Anne and Roswall, Nina and Overvad, Kim and Weikert, Steffen and Boeing, Heiner and Chang-Claude, Jenny and Teucher, Birgit and Panico, Salvatore and Sacerdote, Carlotta and Tumino, Rosario and Palli, Domenico and Sieri, Sabina and Peeters, Petra and Ramon Quiros, Jose and Jakszyn, Paula and Molina-Montes, Esther and Chirlaque, Maria-Dolores and Ardanaz, Eva and Dorronsoro, Miren and Khaw, Kay-Tee and Wareham, Nick and Ljungberg, Borje and Hallmans, Goran and Ehrnström, Roy and Ericson, Ulrika and Torhild Gram, Inger and Parr, Christine L. and Trichopoulou, Antonia and Karapetyan, Tina and Dilis, Vardis and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Fagherrazzi, Guy and Romieu, Isabelle and Gunter, Marc J. and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {nutrients,diet,bladder cancer,cohort studies,epidemiology},
  language     = {eng},
  number       = {3},
  pages        = {635--644},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.27643},
  volume       = {132},
  year         = {2013},
}