Unilateral denervation of the rat urinary bladder and reinnervation: a predominance for ipsilateral changes
(1986) In Acta Physiologica Scandinavica 127(2). p.223-231- Abstract
- Unilateral removal of the pelvic ganglion affected the bladder-half on the denervated side more profoundly than that on the non-denervated side. At an early stage (3-7 days) the former was heavier, had a lower choline acetyltransferase activity, developed less tension to nerve stimulation and, in course of time, became more sensitized to methacholine in vitro than the latter. At a late stage (30-60 days) the nerve-evoked contractile responses on the denervated side had increased, which was almost wholly attributed to the atropine-sensitive part of the contraction, but the recovery was not complete. On the non-denervated side the nerve-evoked responses were not significantly changed. It was calculated that in the normally innervated... (More)
- Unilateral removal of the pelvic ganglion affected the bladder-half on the denervated side more profoundly than that on the non-denervated side. At an early stage (3-7 days) the former was heavier, had a lower choline acetyltransferase activity, developed less tension to nerve stimulation and, in course of time, became more sensitized to methacholine in vitro than the latter. At a late stage (30-60 days) the nerve-evoked contractile responses on the denervated side had increased, which was almost wholly attributed to the atropine-sensitive part of the contraction, but the recovery was not complete. On the non-denervated side the nerve-evoked responses were not significantly changed. It was calculated that in the normally innervated bladders 25-30% of the cholinergic nerves of each half were of contralateral origin. The figure was lower (18%) for the nerves mediating the atropine-resistant response. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1103617
- author
- Ekstrom, J ; Malmberg, Lars LU and Oberg, S
- organization
- publishing date
- 1986
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Physiologica Scandinavica
- volume
- 127
- issue
- 2
- pages
- 223 - 231
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:3524118
- scopus:0022591702
- ISSN
- 0001-6772
- language
- English
- LU publication?
- yes
- id
- a1ddb064-ad61-4752-bf53-d87ca4ce9999 (old id 1103617)
- date added to LUP
- 2016-04-01 16:52:57
- date last changed
- 2021-01-03 07:55:46
@article{a1ddb064-ad61-4752-bf53-d87ca4ce9999,
abstract = {{Unilateral removal of the pelvic ganglion affected the bladder-half on the denervated side more profoundly than that on the non-denervated side. At an early stage (3-7 days) the former was heavier, had a lower choline acetyltransferase activity, developed less tension to nerve stimulation and, in course of time, became more sensitized to methacholine in vitro than the latter. At a late stage (30-60 days) the nerve-evoked contractile responses on the denervated side had increased, which was almost wholly attributed to the atropine-sensitive part of the contraction, but the recovery was not complete. On the non-denervated side the nerve-evoked responses were not significantly changed. It was calculated that in the normally innervated bladders 25-30% of the cholinergic nerves of each half were of contralateral origin. The figure was lower (18%) for the nerves mediating the atropine-resistant response.}},
author = {{Ekstrom, J and Malmberg, Lars and Oberg, S}},
issn = {{0001-6772}},
language = {{eng}},
number = {{2}},
pages = {{223--231}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Physiologica Scandinavica}},
title = {{Unilateral denervation of the rat urinary bladder and reinnervation: a predominance for ipsilateral changes}},
volume = {{127}},
year = {{1986}},
}