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Rapid analysis methods for paralytic shellfish poisoning toxins (PSTs) monitoring in raw waters

Li, Jing LU and Persson, Kenneth M LU (2020) In Vatten: tidskrift för vattenvård /Journal of Water Management and research 1(76). p.23-29
Abstract
The presence of paralytic shellfish poisoning toxins (PSTs) in drinking water resources has urged the development of simple and fast screening tools for drinking water surveillance. This article aims to validate
a quick test kit for freshwater PSTs detection. Preliminary estimates of the limit of detection (LODs)
were done for 5 PSPs variants, namely C1 toxin (a “C” toxin); GTX5(a Gonyautoxin); and neosaxitoxin,
dcSaxitoxin and saxitoxin (STX) and a mixture of C1 and saxitoxin. Duplicate samples and Blank/Control are used. In total 50 samples were tested plus 7 negative controls. Results show that clear estimated
LOD levels for all variants except for C1. Further validation for lower detection limits is recommended if
a... (More)
The presence of paralytic shellfish poisoning toxins (PSTs) in drinking water resources has urged the development of simple and fast screening tools for drinking water surveillance. This article aims to validate
a quick test kit for freshwater PSTs detection. Preliminary estimates of the limit of detection (LODs)
were done for 5 PSPs variants, namely C1 toxin (a “C” toxin); GTX5(a Gonyautoxin); and neosaxitoxin,
dcSaxitoxin and saxitoxin (STX) and a mixture of C1 and saxitoxin. Duplicate samples and Blank/Control are used. In total 50 samples were tested plus 7 negative controls. Results show that clear estimated
LOD levels for all variants except for C1. Further validation for lower detection limits is recommended if
a lower concentration is of concern. Owing to cross-reactivity within the different derivatives, water operators/managers should be aware of certain false-negative risks to certain variants. Therefore, a thorough
understanding of the toxin profile in source water is necessary for its application. (Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Saxitoxin, quick test kit, LFA, detection limit, validation
in
Vatten: tidskrift för vattenvård /Journal of Water Management and research
volume
1
issue
76
article number
1
pages
23 - 29
publisher
Föreningen Vatten
ISSN
0042-2886
language
English
LU publication?
yes
id
a1ec284d-cb1c-457e-afdf-7241d53870f5
alternative location
http://www.tidskriftenvatten.se/wp-content/uploads/2020/03/VATTEN_2020_1_23-29.pdf
date added to LUP
2020-05-03 05:46:31
date last changed
2020-05-04 10:58:53
@article{a1ec284d-cb1c-457e-afdf-7241d53870f5,
  abstract     = {{The presence of paralytic shellfish poisoning toxins (PSTs) in drinking water resources has urged the development of simple and fast screening tools for drinking water surveillance. This article aims to validate<br/>a quick test kit for freshwater PSTs detection. Preliminary estimates of the limit of detection (LODs)<br/>were done for 5 PSPs variants, namely C1 toxin (a “C” toxin); GTX5(a Gonyautoxin); and neosaxitoxin,<br/>dcSaxitoxin and saxitoxin (STX) and a mixture of C1 and saxitoxin. Duplicate samples and Blank/Control are used. In total 50 samples were tested plus 7 negative controls. Results show that clear estimated<br/>LOD levels for all variants except for C1. Further validation for lower detection limits is recommended if<br/>a lower concentration is of concern. Owing to cross-reactivity within the different derivatives, water operators/managers should be aware of certain false-negative risks to certain variants. Therefore, a thorough<br/>understanding of the toxin profile in source water is necessary for its application.}},
  author       = {{Li, Jing and Persson, Kenneth M}},
  issn         = {{0042-2886}},
  keywords     = {{Saxitoxin; quick test kit; LFA; detection limit; validation}},
  language     = {{eng}},
  number       = {{76}},
  pages        = {{23--29}},
  publisher    = {{Föreningen Vatten}},
  series       = {{Vatten: tidskrift för vattenvård /Journal of Water Management and research}},
  title        = {{Rapid analysis methods for paralytic shellfish poisoning toxins (PSTs) monitoring in raw waters}},
  url          = {{http://www.tidskriftenvatten.se/wp-content/uploads/2020/03/VATTEN_2020_1_23-29.pdf}},
  volume       = {{1}},
  year         = {{2020}},
}