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Effect of electrolytes on the sol–gel phase transitions in a Pluronic F127/carboxymethyl cellulose aqueous system : Phase map, rheology and NMR self-diffusion study

Monduzzi, Maura ; Musu, Giulia ; Grosso, Massimiliano ; Carucci, Cristina LU orcid ; Lindman, Björn LU ; Söderman, Olle LU and Salis, Andrea LU (2022) In European Polymer Journal 181.
Abstract

This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting of the copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in a ratio of 20/4 by weight, in the presence of different concentrations of Na2SO4, NaCl, and NaSCN, was investigated using the visual inversion tube approach to estimate a phase map, and then characterized through rheological measurements. The formation of a cubic liquid crystalline phase at temperatures higher than 37 °C was suggested in all systems. The complex viscosity, decreases in the presence of salts in the order Na2SO4 > NaCl > NaSCN... (More)

This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting of the copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in a ratio of 20/4 by weight, in the presence of different concentrations of Na2SO4, NaCl, and NaSCN, was investigated using the visual inversion tube approach to estimate a phase map, and then characterized through rheological measurements. The formation of a cubic liquid crystalline phase at temperatures higher than 37 °C was suggested in all systems. The complex viscosity, decreases in the presence of salts in the order Na2SO4 > NaCl > NaSCN with more marked effect for lower concentrations. Salt addition allows to tune the crowding effect of NaCMC. For the polymer mixture and for a sample containing NaCl, 1H NMR self-diffusion experiments display a non-mono-exponential decay of the echo signals of Pluronic F127, caused by the polydispersity of commercial Pluronic F127. The rheological properties along with the diffusion behaviour of the liquid crystal micelles suggest that a sample containing NaCl 0.07 mol/kg, with a sol-hard gel transition temperature around 35 °C, close to that of the body, may be a suitable and biocompatible thermosensitive platform to administer both hydrophobic and hydrophilic drugs such as antibiotics, anticancer drugs or growing factors. Synopsis: A simple thermoresponsive platform for drug delivery: Pluronic F127, NaCMC and NaCl.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Electrolytes, NaCMC, Pluronic F127, Thermoresponsive hydrogels
in
European Polymer Journal
volume
181
article number
111707
publisher
Elsevier
external identifiers
  • scopus:85142140644
ISSN
0014-3057
DOI
10.1016/j.eurpolymj.2022.111707
language
English
LU publication?
yes
id
a1eff319-3bb1-4a01-a67b-c5b3fb7a8363
date added to LUP
2022-12-28 14:17:13
date last changed
2022-12-28 14:17:13
@article{a1eff319-3bb1-4a01-a67b-c5b3fb7a8363,
  abstract     = {{<p>This investigation aims to obtain a thermosensitive platform useful for specific nanomedicine applications through the addition of suitable salts. An aqueous mixture consisting of the copolymer Pluronic F127 and sodium carboxymethyl-cellulose, in a ratio of 20/4 by weight, in the presence of different concentrations of Na<sub>2</sub>SO<sub>4</sub>, NaCl, and NaSCN, was investigated using the visual inversion tube approach to estimate a phase map, and then characterized through rheological measurements. The formation of a cubic liquid crystalline phase at temperatures higher than 37 °C was suggested in all systems. The complex viscosity, decreases in the presence of salts in the order Na<sub>2</sub>SO<sub>4</sub> &gt; NaCl &gt; NaSCN with more marked effect for lower concentrations. Salt addition allows to tune the crowding effect of NaCMC. For the polymer mixture and for a sample containing NaCl, <sup>1</sup>H NMR self-diffusion experiments display a non-mono-exponential decay of the echo signals of Pluronic F127, caused by the polydispersity of commercial Pluronic F127. The rheological properties along with the diffusion behaviour of the liquid crystal micelles suggest that a sample containing NaCl 0.07 mol/kg, with a sol-hard gel transition temperature around 35 °C, close to that of the body, may be a suitable and biocompatible thermosensitive platform to administer both hydrophobic and hydrophilic drugs such as antibiotics, anticancer drugs or growing factors. Synopsis: A simple thermoresponsive platform for drug delivery: Pluronic F127, NaCMC and NaCl.</p>}},
  author       = {{Monduzzi, Maura and Musu, Giulia and Grosso, Massimiliano and Carucci, Cristina and Lindman, Björn and Söderman, Olle and Salis, Andrea}},
  issn         = {{0014-3057}},
  keywords     = {{Electrolytes; NaCMC; Pluronic F127; Thermoresponsive hydrogels}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{European Polymer Journal}},
  title        = {{Effect of electrolytes on the sol–gel phase transitions in a Pluronic F127/carboxymethyl cellulose aqueous system : Phase map, rheology and NMR self-diffusion study}},
  url          = {{http://dx.doi.org/10.1016/j.eurpolymj.2022.111707}},
  doi          = {{10.1016/j.eurpolymj.2022.111707}},
  volume       = {{181}},
  year         = {{2022}},
}