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Peptide-Oleate Complexes Create Novel Membrane-Bound Compartments

Hansen, Jesper S. LU ; Tran, Tuan Hiep LU ; Cavalera, Michele LU ; Paul, Sanchari LU ; Chaudhuri, Arunima LU ; Lindkvist-Petersson, Karin LU ; Ho, James C.S. LU and Svanborg, Catharina LU (2020) In Molecular biology and evolution 37(11). p.3083-3093
Abstract

A challenging question in evolutionary theory is the origin of cell division and plausible molecular mechanisms involved. Here, we made the surprising observation that complexes formed by short alpha-helical peptides and oleic acid can create multiple membrane-enclosed spaces from a single lipid vesicle. The findings suggest that such complexes may contain the molecular information necessary to initiate and sustain this process. Based on these observations, we propose a new molecular model to understand protocell division.

Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cell division, giant unilamellar vesicles, oleic acid, peptides, peptide–oleate complexes, phospholipids, protocells
in
Molecular biology and evolution
volume
37
issue
11
pages
11 pages
publisher
Oxford University Press
external identifiers
  • scopus:85096814165
  • pmid:32521018
ISSN
0737-4038
DOI
10.1093/molbev/msaa138
language
English
LU publication?
yes
id
a1f5ea5f-b838-4db4-96b3-c0bfb59d479a
date added to LUP
2021-01-14 16:03:42
date last changed
2025-04-18 11:21:30
@article{a1f5ea5f-b838-4db4-96b3-c0bfb59d479a,
  abstract     = {{<p>A challenging question in evolutionary theory is the origin of cell division and plausible molecular mechanisms involved. Here, we made the surprising observation that complexes formed by short alpha-helical peptides and oleic acid can create multiple membrane-enclosed spaces from a single lipid vesicle. The findings suggest that such complexes may contain the molecular information necessary to initiate and sustain this process. Based on these observations, we propose a new molecular model to understand protocell division.</p>}},
  author       = {{Hansen, Jesper S. and Tran, Tuan Hiep and Cavalera, Michele and Paul, Sanchari and Chaudhuri, Arunima and Lindkvist-Petersson, Karin and Ho, James C.S. and Svanborg, Catharina}},
  issn         = {{0737-4038}},
  keywords     = {{cell division; giant unilamellar vesicles; oleic acid; peptides; peptide–oleate complexes; phospholipids; protocells}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{11}},
  pages        = {{3083--3093}},
  publisher    = {{Oxford University Press}},
  series       = {{Molecular biology and evolution}},
  title        = {{Peptide-Oleate Complexes Create Novel Membrane-Bound Compartments}},
  url          = {{http://dx.doi.org/10.1093/molbev/msaa138}},
  doi          = {{10.1093/molbev/msaa138}},
  volume       = {{37}},
  year         = {{2020}},
}