Increased plasma levels of heparin-binding protein on admission to intensive care are associated with respiratory and circulatory failure
(2016) In PLoS ONE 11(3).- Abstract
Purpose: Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure. Methods: This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score... (More)
Purpose: Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure. Methods: This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score (SAPS) 3 was recorded on admission. Sequential organ failure assessment (SOFA) scores were recorded daily for three days. Results: Median SAPS 3 was 58.8 (48-70) and 30-day mortality 64/278 (23%). There was an association between high plasma concentrations of HBP on admission with decreased oxygenation (p
(Less)
- author
- Tydén, Jonas
; Herwald, Heiko
LU
; Sjöberg, Folke and Johansson, Joakim
- organization
- publishing date
- 2016-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 11
- issue
- 3
- article number
- e0152035
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000372701200089
- pmid:27007333
- scopus:84962052953
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0152035
- language
- English
- LU publication?
- yes
- id
- a1fb948a-8e6b-479c-b492-a398d825719a
- date added to LUP
- 2016-05-31 12:02:43
- date last changed
- 2025-01-25 08:23:51
@article{a1fb948a-8e6b-479c-b492-a398d825719a, abstract = {{<p>Purpose: Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure. Methods: This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score (SAPS) 3 was recorded on admission. Sequential organ failure assessment (SOFA) scores were recorded daily for three days. Results: Median SAPS 3 was 58.8 (48-70) and 30-day mortality 64/278 (23%). There was an association between high plasma concentrations of HBP on admission with decreased oxygenation (p</p>}}, author = {{Tydén, Jonas and Herwald, Heiko and Sjöberg, Folke and Johansson, Joakim}}, issn = {{1932-6203}}, language = {{eng}}, month = {{03}}, number = {{3}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Increased plasma levels of heparin-binding protein on admission to intensive care are associated with respiratory and circulatory failure}}, url = {{http://dx.doi.org/10.1371/journal.pone.0152035}}, doi = {{10.1371/journal.pone.0152035}}, volume = {{11}}, year = {{2016}}, }