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Increased plasma levels of heparin-binding protein on admission to intensive care are associated with respiratory and circulatory failure

Tydén, Jonas; Herwald, Heiko LU ; Sjöberg, Folke and Johansson, Joakim (2016) In PLoS One 11(3).
Abstract

Purpose: Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure. Methods: This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score... (More)

Purpose: Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure. Methods: This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score (SAPS) 3 was recorded on admission. Sequential organ failure assessment (SOFA) scores were recorded daily for three days. Results: Median SAPS 3 was 58.8 (48-70) and 30-day mortality 64/278 (23%). There was an association between high plasma concentrations of HBP on admission with decreased oxygenation (p

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organization
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Contribution to journal
publication status
published
subject
in
PLoS One
volume
11
issue
3
publisher
Public Library of Science
external identifiers
  • Scopus:84962052953
  • WOS:000372701200089
ISSN
1932-6203
DOI
10.1371/journal.pone.0152035
language
English
LU publication?
yes
id
a1fb948a-8e6b-479c-b492-a398d825719a
date added to LUP
2016-05-31 12:02:43
date last changed
2017-01-01 08:27:06
@article{a1fb948a-8e6b-479c-b492-a398d825719a,
  abstract     = {<p>Purpose: Heparin-binding protein (HBP) is released by granulocytes and has been shown to increase vascular permeability in experimental investigations. Increased vascular permeability in the lungs can lead to fluid accumulation in alveoli and respiratory failure. A generalized increase in vascular permeability leads to loss of circulating blood volume and circulatory failure. We hypothesized that plasma concentrations of HBP on admission to the intensive care unit (ICU) would be associated with decreased oxygenation or circulatory failure. Methods: This is a prospective, observational study in a mixed 8-bed ICU. We investigated concentrations of HBP in plasma at admission to the ICU from 278 patients. Simplified acute physiology score (SAPS) 3 was recorded on admission. Sequential organ failure assessment (SOFA) scores were recorded daily for three days. Results: Median SAPS 3 was 58.8 (48-70) and 30-day mortality 64/278 (23%). There was an association between high plasma concentrations of HBP on admission with decreased oxygenation (p</p>},
  articleno    = {e0152035},
  author       = {Tydén, Jonas and Herwald, Heiko and Sjöberg, Folke and Johansson, Joakim},
  issn         = {1932-6203},
  language     = {eng},
  month        = {03},
  number       = {3},
  publisher    = {Public Library of Science},
  series       = {PLoS One},
  title        = {Increased plasma levels of heparin-binding protein on admission to intensive care are associated with respiratory and circulatory failure},
  url          = {http://dx.doi.org/10.1371/journal.pone.0152035},
  volume       = {11},
  year         = {2016},
}