Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
(2021) In The Journal of clinical endocrinology and metabolism 106(10). p.2840-2854- Abstract
- Context: In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with greater bone mineral density (BMD) at the total hip.
Objective: This work aims to investigate these associations longitudinally, by studying T2DM status (no T2DM n = 1521, incident T2DM n = 119, or prevalent T2DM n = 106) in relation to changes in total hip bone area and BMD.
Methods: In 3 cohorts, the Swedish Mammography Cohort Clinical (SMCC; n = 1060), Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 483), and Uppsala Longitudinal Study of Adult Men (ULSAM; n = 203), with repeat assessment of T2DM status and dual energy x-ray absorptiometry (DXA)... (More) - Context: In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with greater bone mineral density (BMD) at the total hip.
Objective: This work aims to investigate these associations longitudinally, by studying T2DM status (no T2DM n = 1521, incident T2DM n = 119, or prevalent T2DM n = 106) in relation to changes in total hip bone area and BMD.
Methods: In 3 cohorts, the Swedish Mammography Cohort Clinical (SMCC; n = 1060), Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 483), and Uppsala Longitudinal Study of Adult Men (ULSAM; n = 203), with repeat assessment of T2DM status and dual energy x-ray absorptiometry (DXA) measurements of total hip bone area and BMD on average 8 years apart, a linear regression model was used to assess the effect of T2DM status on change in bone area and BMD at the total hip.
Results: After meta-analysis, the change in bone area at the total hip was 0.5% lower among those with incident T2DM compared to those without T2DM (-0.18 cm2; 95% CI, -0.30 to -0.06). The change in bone area was similar among those with prevalent T2DM compared to those without (0.00 cm2; 95% CI, -0.13 to 0.13). For BMD, the combined estimate was 0.004 g/cm2 (95% CI, -0.006 to 0.014) among those with incident T2DM and 0.010 g/cm2 (95% CI, -0.000 to 0.020) among those with prevalent T2DM, compared to those without T2DM.
Conclusion: Those with incident T2DM have a lower expansion in bone area at the total hip compared to those without T2DM. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a20e6c28-371a-4e12-b889-344db9adbe5c
- author
- Mitchell, Adam LU ; Fall, Tove ; Melhus, Håkan ; Lind, Lars ; Michaëlsson, Karl and Byberg, Liisa
- publishing date
- 2021-09-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- type 2 diabetes mellitus, bone area, bone mineral density, longitudinal study
- in
- The Journal of clinical endocrinology and metabolism
- volume
- 106
- issue
- 10
- pages
- 15 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85117216902
- ISSN
- 1945-7197
- DOI
- 10.1210/clinem/dgab490
- language
- English
- LU publication?
- no
- id
- a20e6c28-371a-4e12-b889-344db9adbe5c
- date added to LUP
- 2025-01-30 11:40:30
- date last changed
- 2025-04-04 15:19:24
@article{a20e6c28-371a-4e12-b889-344db9adbe5c,
abstract = {{Context: In a cross-sectional study, we found an association between type 2 diabetes mellitus (T2DM) and smaller bone area together with greater bone mineral density (BMD) at the total hip.<br/><br/>Objective: This work aims to investigate these associations longitudinally, by studying T2DM status (no T2DM n = 1521, incident T2DM n = 119, or prevalent T2DM n = 106) in relation to changes in total hip bone area and BMD.<br/><br/>Methods: In 3 cohorts, the Swedish Mammography Cohort Clinical (SMCC; n = 1060), Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 483), and Uppsala Longitudinal Study of Adult Men (ULSAM; n = 203), with repeat assessment of T2DM status and dual energy x-ray absorptiometry (DXA) measurements of total hip bone area and BMD on average 8 years apart, a linear regression model was used to assess the effect of T2DM status on change in bone area and BMD at the total hip.<br/><br/>Results: After meta-analysis, the change in bone area at the total hip was 0.5% lower among those with incident T2DM compared to those without T2DM (-0.18 cm2; 95% CI, -0.30 to -0.06). The change in bone area was similar among those with prevalent T2DM compared to those without (0.00 cm2; 95% CI, -0.13 to 0.13). For BMD, the combined estimate was 0.004 g/cm2 (95% CI, -0.006 to 0.014) among those with incident T2DM and 0.010 g/cm2 (95% CI, -0.000 to 0.020) among those with prevalent T2DM, compared to those without T2DM.<br/><br/>Conclusion: Those with incident T2DM have a lower expansion in bone area at the total hip compared to those without T2DM.}},
author = {{Mitchell, Adam and Fall, Tove and Melhus, Håkan and Lind, Lars and Michaëlsson, Karl and Byberg, Liisa}},
issn = {{1945-7197}},
keywords = {{type 2 diabetes mellitus; bone area; bone mineral density; longitudinal study}},
language = {{eng}},
month = {{09}},
number = {{10}},
pages = {{2840--2854}},
publisher = {{Oxford University Press}},
series = {{The Journal of clinical endocrinology and metabolism}},
title = {{Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years}},
url = {{http://dx.doi.org/10.1210/clinem/dgab490}},
doi = {{10.1210/clinem/dgab490}},
volume = {{106}},
year = {{2021}},
}