Advanced

Impaired nerve regeneration in streptozotocin-diabetic rats. Effects of treatment with an aldose reductase inhibitor

Ekström, Per A R LU and Tomlinson, David R. (1989) In Journal of the Neurological Sciences 93(2-3). p.231-237
Abstract

Rats with streptozotocin-induced diabetes have a decreased rate of sciatic nerve regeneration. We studied the effects on this defect of treatment with the aldose reductase inhibitor, ponalrestat (25 mg/kg per day via an endogastric tube). The nerves of diabetic rats were crush-injured at 5 weeks of diabetes and regeneration evaluated 7 days later with the pinch-reflex test. Ponalrestat treatment was started at day 3 after streptozotocin injection and was continued for the whole experimental period, i.e. until 6 weeks of diabetes. The treatment prevented effectively the accumulation of sorbitol and fructose in the nerves of diabetic rats, but was without effect on the sciatic nerve regeneration (controls 21.8 ± 1.2 mm/7 days (mean ± SEM,... (More)

Rats with streptozotocin-induced diabetes have a decreased rate of sciatic nerve regeneration. We studied the effects on this defect of treatment with the aldose reductase inhibitor, ponalrestat (25 mg/kg per day via an endogastric tube). The nerves of diabetic rats were crush-injured at 5 weeks of diabetes and regeneration evaluated 7 days later with the pinch-reflex test. Ponalrestat treatment was started at day 3 after streptozotocin injection and was continued for the whole experimental period, i.e. until 6 weeks of diabetes. The treatment prevented effectively the accumulation of sorbitol and fructose in the nerves of diabetic rats, but was without effect on the sciatic nerve regeneration (controls 21.8 ± 1.2 mm/7 days (mean ± SEM, n = 6), untreated diabetics 15.8 ± 1.8 (n = 7), ponalrestat-treated diabetics 16.2 ± 1.0 (n = 10)). The results indicate that there is no connection between increased sorbitol pathway flux and impaired regeneration in streptozotocin diabetic rats. © 1989.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aldose reductase inhibitor, Diabetes, Insulin, Nerve regeneration, Rat, Sciatic nerve, Streptozotocin
in
Journal of the Neurological Sciences
volume
93
issue
2-3
pages
231 - 237
publisher
Elsevier
external identifiers
  • scopus:0024437196
ISSN
0022-510X
DOI
10.1016/0022-510X(89)90193-7
language
English
LU publication?
yes
id
a216b7f7-7dbe-4962-8035-f6c9bbdea8e2
date added to LUP
2016-12-07 14:33:00
date last changed
2017-02-05 04:55:54
@article{a216b7f7-7dbe-4962-8035-f6c9bbdea8e2,
  abstract     = {<p>Rats with streptozotocin-induced diabetes have a decreased rate of sciatic nerve regeneration. We studied the effects on this defect of treatment with the aldose reductase inhibitor, ponalrestat (25 mg/kg per day via an endogastric tube). The nerves of diabetic rats were crush-injured at 5 weeks of diabetes and regeneration evaluated 7 days later with the pinch-reflex test. Ponalrestat treatment was started at day 3 after streptozotocin injection and was continued for the whole experimental period, i.e. until 6 weeks of diabetes. The treatment prevented effectively the accumulation of sorbitol and fructose in the nerves of diabetic rats, but was without effect on the sciatic nerve regeneration (controls 21.8 ± 1.2 mm/7 days (mean ± SEM, n = 6), untreated diabetics 15.8 ± 1.8 (n = 7), ponalrestat-treated diabetics 16.2 ± 1.0 (n = 10)). The results indicate that there is no connection between increased sorbitol pathway flux and impaired regeneration in streptozotocin diabetic rats. © 1989.</p>},
  author       = {Ekström, Per A R and Tomlinson, David R.},
  issn         = {0022-510X},
  keyword      = {Aldose reductase inhibitor,Diabetes,Insulin,Nerve regeneration,Rat,Sciatic nerve,Streptozotocin},
  language     = {eng},
  number       = {2-3},
  pages        = {231--237},
  publisher    = {Elsevier},
  series       = {Journal of the Neurological Sciences},
  title        = {Impaired nerve regeneration in streptozotocin-diabetic rats. Effects of treatment with an aldose reductase inhibitor},
  url          = {http://dx.doi.org/10.1016/0022-510X(89)90193-7},
  volume       = {93},
  year         = {1989},
}