Impaired nerve regeneration in streptozotocin-diabetic rats. Effects of treatment with an aldose reductase inhibitor
(1989) In Journal of the Neurological Sciences 93(2-3). p.231-237- Abstract
Rats with streptozotocin-induced diabetes have a decreased rate of sciatic nerve regeneration. We studied the effects on this defect of treatment with the aldose reductase inhibitor, ponalrestat (25 mg/kg per day via an endogastric tube). The nerves of diabetic rats were crush-injured at 5 weeks of diabetes and regeneration evaluated 7 days later with the pinch-reflex test. Ponalrestat treatment was started at day 3 after streptozotocin injection and was continued for the whole experimental period, i.e. until 6 weeks of diabetes. The treatment prevented effectively the accumulation of sorbitol and fructose in the nerves of diabetic rats, but was without effect on the sciatic nerve regeneration (controls 21.8 ± 1.2 mm/7 days (mean ± SEM,... (More)
Rats with streptozotocin-induced diabetes have a decreased rate of sciatic nerve regeneration. We studied the effects on this defect of treatment with the aldose reductase inhibitor, ponalrestat (25 mg/kg per day via an endogastric tube). The nerves of diabetic rats were crush-injured at 5 weeks of diabetes and regeneration evaluated 7 days later with the pinch-reflex test. Ponalrestat treatment was started at day 3 after streptozotocin injection and was continued for the whole experimental period, i.e. until 6 weeks of diabetes. The treatment prevented effectively the accumulation of sorbitol and fructose in the nerves of diabetic rats, but was without effect on the sciatic nerve regeneration (controls 21.8 ± 1.2 mm/7 days (mean ± SEM, n = 6), untreated diabetics 15.8 ± 1.8 (n = 7), ponalrestat-treated diabetics 16.2 ± 1.0 (n = 10)). The results indicate that there is no connection between increased sorbitol pathway flux and impaired regeneration in streptozotocin diabetic rats.
(Less)
- author
- Ekström, Per A R LU and Tomlinson, David R.
- organization
- publishing date
- 1989
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aldose reductase inhibitor, Diabetes, Insulin, Nerve regeneration, Rat, Sciatic nerve, Streptozotocin
- in
- Journal of the Neurological Sciences
- volume
- 93
- issue
- 2-3
- pages
- 231 - 237
- publisher
- Elsevier
- external identifiers
-
- scopus:0024437196
- pmid:2531788
- ISSN
- 0022-510X
- DOI
- 10.1016/0022-510X(89)90193-7
- language
- English
- LU publication?
- yes
- id
- a216b7f7-7dbe-4962-8035-f6c9bbdea8e2
- date added to LUP
- 2016-12-07 14:33:00
- date last changed
- 2024-06-15 22:20:41
@article{a216b7f7-7dbe-4962-8035-f6c9bbdea8e2,
abstract = {{<p>Rats with streptozotocin-induced diabetes have a decreased rate of sciatic nerve regeneration. We studied the effects on this defect of treatment with the aldose reductase inhibitor, ponalrestat (25 mg/kg per day via an endogastric tube). The nerves of diabetic rats were crush-injured at 5 weeks of diabetes and regeneration evaluated 7 days later with the pinch-reflex test. Ponalrestat treatment was started at day 3 after streptozotocin injection and was continued for the whole experimental period, i.e. until 6 weeks of diabetes. The treatment prevented effectively the accumulation of sorbitol and fructose in the nerves of diabetic rats, but was without effect on the sciatic nerve regeneration (controls 21.8 ± 1.2 mm/7 days (mean ± SEM, n = 6), untreated diabetics 15.8 ± 1.8 (n = 7), ponalrestat-treated diabetics 16.2 ± 1.0 (n = 10)). The results indicate that there is no connection between increased sorbitol pathway flux and impaired regeneration in streptozotocin diabetic rats.</p>}},
author = {{Ekström, Per A R and Tomlinson, David R.}},
issn = {{0022-510X}},
keywords = {{Aldose reductase inhibitor; Diabetes; Insulin; Nerve regeneration; Rat; Sciatic nerve; Streptozotocin}},
language = {{eng}},
number = {{2-3}},
pages = {{231--237}},
publisher = {{Elsevier}},
series = {{Journal of the Neurological Sciences}},
title = {{Impaired nerve regeneration in streptozotocin-diabetic rats. Effects of treatment with an aldose reductase inhibitor}},
url = {{http://dx.doi.org/10.1016/0022-510X(89)90193-7}},
doi = {{10.1016/0022-510X(89)90193-7}},
volume = {{93}},
year = {{1989}},
}