Quality control and testing of 99Tc(m) macroaggregated albumin
Darte, L. LU and Persson, B. R. LU
(1976)
In Nuklearmedizin
15(2).
p.80-85
- Abstract
(99m)Tc labelled macroaggregated albumin particles prepared from a commercial 'kit' have been tested in detail. With the introduction of the method of gel chromatography column scanning it became possible to make fast and simple quantitative measurements of the radiochemical purity. This was found to be the only reliable method for quantitative determination of non aggregated (99m)Tc labelled albumin. The measuring results of the kit in question have shown a labelling efficiency of about 97-99%. In addition to a few percent of (99m)Tc pertechnetate less than 0.5% of disturbing radioactivity was found. The labelling was stable for at least 5-6 h. About 80% of the particles are in the size range of 10-80 μm. A rough estimation of the... (More)
(99m)Tc labelled macroaggregated albumin particles prepared from a commercial 'kit' have been tested in detail. With the introduction of the method of gel chromatography column scanning it became possible to make fast and simple quantitative measurements of the radiochemical purity. This was found to be the only reliable method for quantitative determination of non aggregated (99m)Tc labelled albumin. The measuring results of the kit in question have shown a labelling efficiency of about 97-99%. In addition to a few percent of (99m)Tc pertechnetate less than 0.5% of disturbing radioactivity was found. The labelling was stable for at least 5-6 h. About 80% of the particles are in the size range of 10-80 μm. A rough estimation of the number of particles in the solution resulted in 0.4 x 106 per mg of MAA. The dynamic studies of lung uptake and elimination of (99m)Tc MAA in man resulted in a biological half time in the lungs of about 1-2 h. The radiation absorbed dose to the lungs per mCi administered (99m)Tc MAA was estimated as 0.1 rad. Less than 1% of the radioactivity accumulated in liver, spleen or kidneys during the first 25 minutes after injection.
(Less)
- author
- Darte, L.
LU
and Persson, B. R.
LU
- organization
- publishing date
- 1976-12-01
- type
- Contribution to journal
- publication status
- published
- in
- Nuklearmedizin
- volume
- 15
- issue
- 2
- pages
- 6 pages
- publisher
- Schattauer GmbH
- external identifiers
-
- scopus:0017179489
- pmid:1272817
- ISSN
- 0029-5566
- language
- English
- LU publication?
- yes
- id
- a216ff25-3103-48ef-ad68-bdcdeddbe877
- date added to LUP
- 2020-08-30 21:05:27
- date last changed
- 2024-01-02 17:29:38
@article{a216ff25-3103-48ef-ad68-bdcdeddbe877,
abstract = {{<p>(99m)Tc labelled macroaggregated albumin particles prepared from a commercial 'kit' have been tested in detail. With the introduction of the method of gel chromatography column scanning it became possible to make fast and simple quantitative measurements of the radiochemical purity. This was found to be the only reliable method for quantitative determination of non aggregated (99m)Tc labelled albumin. The measuring results of the kit in question have shown a labelling efficiency of about 97-99%. In addition to a few percent of (99m)Tc pertechnetate less than 0.5% of disturbing radioactivity was found. The labelling was stable for at least 5-6 h. About 80% of the particles are in the size range of 10-80 μm. A rough estimation of the number of particles in the solution resulted in 0.4 x 10<sup>6</sup> per mg of MAA. The dynamic studies of lung uptake and elimination of (99m)Tc MAA in man resulted in a biological half time in the lungs of about 1-2 h. The radiation absorbed dose to the lungs per mCi administered (99m)Tc MAA was estimated as 0.1 rad. Less than 1% of the radioactivity accumulated in liver, spleen or kidneys during the first 25 minutes after injection.</p>}},
author = {{Darte, L. and Persson, B. R.}},
issn = {{0029-5566}},
language = {{eng}},
month = {{12}},
number = {{2}},
pages = {{80--85}},
publisher = {{Schattauer GmbH}},
series = {{Nuklearmedizin}},
title = {{Quality control and testing of <sup>99</sup>Tc(m) macroaggregated albumin}},
volume = {{15}},
year = {{1976}},
}