Advanced

Quality control and testing of 99Tc(m) macroaggregated albumin

Darte, L. LU and Persson, B. R. LU (1976) In NUCL.MED. 15(2). p.80-85
Abstract

(99m)Tc labelled macroaggregated albumin particles prepared from a commercial 'kit' have been tested in detail. With the introduction of the method of gel chromatography column scanning it became possible to make fast and simple quantitative measurements of the radiochemical purity. This was found to be the only reliable method for quantitative determination of non aggregated (99m)Tc labelled albumin. The measuring results of the kit in question have shown a labelling efficiency of about 97-99%. In addition to a few percent of (99m)Tc pertechnetate less than 0.5% of disturbing radioactivity was found. The labelling was stable for at least 5-6 h. About 80% of the particles are in the size range of 10-80 μm. A rough estimation of the... (More)

(99m)Tc labelled macroaggregated albumin particles prepared from a commercial 'kit' have been tested in detail. With the introduction of the method of gel chromatography column scanning it became possible to make fast and simple quantitative measurements of the radiochemical purity. This was found to be the only reliable method for quantitative determination of non aggregated (99m)Tc labelled albumin. The measuring results of the kit in question have shown a labelling efficiency of about 97-99%. In addition to a few percent of (99m)Tc pertechnetate less than 0.5% of disturbing radioactivity was found. The labelling was stable for at least 5-6 h. About 80% of the particles are in the size range of 10-80 μm. A rough estimation of the number of particles in the solution resulted in 0.4 x 106 per mg of MAA. The dynamic studies of lung uptake and elimination of (99m)Tc MAA in man resulted in a biological half time in the lungs of about 1-2 h. The radiation absorbed dose to the lungs per mCi administered (99m)Tc MAA was estimated as 0.1 rad. Less than 1% of the radioactivity accumulated in liver, spleen or kidneys during the first 25 minutes after injection.

(Less)
Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
in
NUCL.MED.
volume
15
issue
2
pages
6 pages
publisher
Schattauer
external identifiers
  • pmid:1272817
  • scopus:0017179489
ISSN
0029-5566
language
English
LU publication?
yes
id
a216ff25-3103-48ef-ad68-bdcdeddbe877
date added to LUP
2020-08-30 21:05:27
date last changed
2020-09-01 16:06:59
@article{a216ff25-3103-48ef-ad68-bdcdeddbe877,
  abstract     = {<p>(99m)Tc labelled macroaggregated albumin particles prepared from a commercial 'kit' have been tested in detail. With the introduction of the method of gel chromatography column scanning it became possible to make fast and simple quantitative measurements of the radiochemical purity. This was found to be the only reliable method for quantitative determination of non aggregated (99m)Tc labelled albumin. The measuring results of the kit in question have shown a labelling efficiency of about 97-99%. In addition to a few percent of (99m)Tc pertechnetate less than 0.5% of disturbing radioactivity was found. The labelling was stable for at least 5-6 h. About 80% of the particles are in the size range of 10-80 μm. A rough estimation of the number of particles in the solution resulted in 0.4 x 10<sup>6</sup> per mg of MAA. The dynamic studies of lung uptake and elimination of (99m)Tc MAA in man resulted in a biological half time in the lungs of about 1-2 h. The radiation absorbed dose to the lungs per mCi administered (99m)Tc MAA was estimated as 0.1 rad. Less than 1% of the radioactivity accumulated in liver, spleen or kidneys during the first 25 minutes after injection.</p>},
  author       = {Darte, L. and Persson, B. R.},
  issn         = {0029-5566},
  language     = {eng},
  month        = {12},
  number       = {2},
  pages        = {80--85},
  publisher    = {Schattauer},
  series       = {NUCL.MED.},
  title        = {Quality control and testing of <sup>99</sup>Tc(m) macroaggregated albumin},
  volume       = {15},
  year         = {1976},
}