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Accumulation of transposable elements in hox gene clusters during adaptive radiation of anolis lizards

Feiner, Nathalie LU (2016) In Proceedings of the Royal Society B: Biological Sciences 283(1840).
Abstract

Transposable elements (TEs) are DNA sequences that can insert elsewhere in the genome and modify genome structure and gene regulation. The role of TEs in evolution is contentious. One hypothesis posits that TE activity generates genomic incompatibilities that can cause reproductive isolation between incipient species. This predicts that TEs will accumulate during speciation events. Here, I tested the prediction that extant lineages with a relatively high rate of speciation have a high number of TEs in their genomes. I sequenced and analysed the TE content of a marker genomic region (Hox clusters) in Anolis lizards, a classic case of an adaptive radiation. Unlike other vertebrates, including closely related lizards, Anolis lizards have... (More)

Transposable elements (TEs) are DNA sequences that can insert elsewhere in the genome and modify genome structure and gene regulation. The role of TEs in evolution is contentious. One hypothesis posits that TE activity generates genomic incompatibilities that can cause reproductive isolation between incipient species. This predicts that TEs will accumulate during speciation events. Here, I tested the prediction that extant lineages with a relatively high rate of speciation have a high number of TEs in their genomes. I sequenced and analysed the TE content of a marker genomic region (Hox clusters) in Anolis lizards, a classic case of an adaptive radiation. Unlike other vertebrates, including closely related lizards, Anolis lizards have high numbers of TEs in their Hox clusters, genomic regions that regulate development of the morphological adaptations that characterize habitat specialists in these lizards. Following a burst of TE activity in the lineage leading to extant Anolis, TEs have continued to accumulate during or after speciation events, resulting in a positive relationship between TE density and lineage speciation rate. These results are consistent with the prediction that TE activity contributes to adaptive radiation by promoting speciation. Although there was no evidence that TE density per se is associated with ecological morphology, the activity of TEs in Hox clusters could have been a rich source for phenotypic variation that may have facilitated the rapid parallel morphological adaptation to microhabitats seen in extant Anolis lizards.

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organization
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Contribution to journal
publication status
published
subject
keywords
Adaptive radiation, Anolis lizards, Hox gene cluster, Speciation, Transposable elements
in
Proceedings of the Royal Society B: Biological Sciences
volume
283
issue
1840
publisher
Royal Society
external identifiers
  • scopus:84991677873
  • wos:000386490000010
ISSN
0962-8452
DOI
10.1098/rspb.2016.1555
language
English
LU publication?
yes
id
a2713976-e516-4461-aeb6-a554ded98101
date added to LUP
2016-11-14 11:40:45
date last changed
2017-01-01 08:39:32
@article{a2713976-e516-4461-aeb6-a554ded98101,
  abstract     = {<p>Transposable elements (TEs) are DNA sequences that can insert elsewhere in the genome and modify genome structure and gene regulation. The role of TEs in evolution is contentious. One hypothesis posits that TE activity generates genomic incompatibilities that can cause reproductive isolation between incipient species. This predicts that TEs will accumulate during speciation events. Here, I tested the prediction that extant lineages with a relatively high rate of speciation have a high number of TEs in their genomes. I sequenced and analysed the TE content of a marker genomic region (Hox clusters) in Anolis lizards, a classic case of an adaptive radiation. Unlike other vertebrates, including closely related lizards, Anolis lizards have high numbers of TEs in their Hox clusters, genomic regions that regulate development of the morphological adaptations that characterize habitat specialists in these lizards. Following a burst of TE activity in the lineage leading to extant Anolis, TEs have continued to accumulate during or after speciation events, resulting in a positive relationship between TE density and lineage speciation rate. These results are consistent with the prediction that TE activity contributes to adaptive radiation by promoting speciation. Although there was no evidence that TE density per se is associated with ecological morphology, the activity of TEs in Hox clusters could have been a rich source for phenotypic variation that may have facilitated the rapid parallel morphological adaptation to microhabitats seen in extant Anolis lizards.</p>},
  articleno    = {20161555},
  author       = {Feiner, Nathalie},
  issn         = {0962-8452},
  keyword      = {Adaptive radiation,Anolis lizards,Hox gene cluster,Speciation,Transposable elements},
  language     = {eng},
  month        = {10},
  number       = {1840},
  publisher    = {Royal Society},
  series       = {Proceedings of the Royal Society B: Biological Sciences},
  title        = {Accumulation of transposable elements in hox gene clusters during adaptive radiation of anolis lizards},
  url          = {http://dx.doi.org/10.1098/rspb.2016.1555},
  volume       = {283},
  year         = {2016},
}