Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer

Aaltonen, Kirsimari ; Amini, Rose-Marie ; Landberg, Göran LU ; Eerola, Hannaleena ; Aittomaki, Kristiina ; Heikkila, Paivi ; Nevanlinna, Heli and Blomqvist, Carl (2009) In Breast Cancer Research and Treatment 113(1). p.75-82
Abstract
Cyclins D1 and E play an important role in breast carcinogenesis. High cyclin E expression is common in hormone receptor negative and high grade aggressive breast cancer, whereas cyclin D1 in hormone receptor positive and low grade breast cancer. Experimental data has suggested that cyclin D1 and E mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer. To test this hypotheses in large breast cancer material and to clarify the histopathological correlations of cyclin E and D1, especially the association with proliferation, we analyzed cyclin E and D1 immunohistochemical expression on breast tumour microarrays consisting of 1348 invasive breast cancers. High cyclin D1 expression was... (More)
Cyclins D1 and E play an important role in breast carcinogenesis. High cyclin E expression is common in hormone receptor negative and high grade aggressive breast cancer, whereas cyclin D1 in hormone receptor positive and low grade breast cancer. Experimental data has suggested that cyclin D1 and E mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer. To test this hypotheses in large breast cancer material and to clarify the histopathological correlations of cyclin E and D1, especially the association with proliferation, we analyzed cyclin E and D1 immunohistochemical expression on breast tumour microarrays consisting of 1348 invasive breast cancers. High cyclin D1 expression was associated with high grade (P < 0.0005), high cyclin A (P < 0.0005) and Ki67 (P < 0.0005) expression among ER positive but with low grade (P = 0.05) and low Ki67 (P = 0.01) expression among ER negative breast cancers. Cyclin E and D1 expression correlated positively in ER positive (P < 0.0005) but had a negative correlation in ER negative tumours (P = 0.004). Cyclin E associated with high grade among all tumours (P < 0.0005). In conclusion, the findings of this study show that cyclin D1 has separate roles, and proliferation is driven by different mechanisms in ER positive and negative breast cancers. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Proliferation, Estrogen receptor, Breast cancer, Cyclin D1, Cyclin E
in
Breast Cancer Research and Treatment
volume
113
issue
1
pages
75 - 82
publisher
Springer
external identifiers
  • wos:000261951100009
  • scopus:58049216746
  • pmid:18240019
ISSN
1573-7217
DOI
10.1007/s10549-008-9908-5
language
English
LU publication?
yes
id
a29736c6-badb-469b-ae10-b5e581fee0f1 (old id 1313829)
date added to LUP
2016-04-01 13:56:14
date last changed
2022-03-14 02:49:18
@article{a29736c6-badb-469b-ae10-b5e581fee0f1,
  abstract     = {{Cyclins D1 and E play an important role in breast carcinogenesis. High cyclin E expression is common in hormone receptor negative and high grade aggressive breast cancer, whereas cyclin D1 in hormone receptor positive and low grade breast cancer. Experimental data has suggested that cyclin D1 and E mediate cell proliferation by different mechanisms in estrogen receptor (ER) positive and negative breast cancer. To test this hypotheses in large breast cancer material and to clarify the histopathological correlations of cyclin E and D1, especially the association with proliferation, we analyzed cyclin E and D1 immunohistochemical expression on breast tumour microarrays consisting of 1348 invasive breast cancers. High cyclin D1 expression was associated with high grade (P &lt; 0.0005), high cyclin A (P &lt; 0.0005) and Ki67 (P &lt; 0.0005) expression among ER positive but with low grade (P = 0.05) and low Ki67 (P = 0.01) expression among ER negative breast cancers. Cyclin E and D1 expression correlated positively in ER positive (P &lt; 0.0005) but had a negative correlation in ER negative tumours (P = 0.004). Cyclin E associated with high grade among all tumours (P &lt; 0.0005). In conclusion, the findings of this study show that cyclin D1 has separate roles, and proliferation is driven by different mechanisms in ER positive and negative breast cancers.}},
  author       = {{Aaltonen, Kirsimari and Amini, Rose-Marie and Landberg, Göran and Eerola, Hannaleena and Aittomaki, Kristiina and Heikkila, Paivi and Nevanlinna, Heli and Blomqvist, Carl}},
  issn         = {{1573-7217}},
  keywords     = {{Proliferation; Estrogen receptor; Breast cancer; Cyclin D1; Cyclin E}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{75--82}},
  publisher    = {{Springer}},
  series       = {{Breast Cancer Research and Treatment}},
  title        = {{Cyclin D1 expression is associated with poor prognostic features in estrogen receptor positive breast cancer}},
  url          = {{http://dx.doi.org/10.1007/s10549-008-9908-5}},
  doi          = {{10.1007/s10549-008-9908-5}},
  volume       = {{113}},
  year         = {{2009}},
}