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Risk factor exposure among hepatitis C virus RNA positive Swedish blood donors--the role of parenteral and sexual transmission

Shev, S ; Hermodsson, S ; Lindholm, A ; Malm, E ; Widell, Anders LU and Norkrans, G (1995) In Scandinavian Journal of Infectious Diseases 27(2). p.99-104
Abstract
The potential modes of transmission for hepatitis C virus (HCV) infections were studied using a multivariate analysis of risk factor exposure among 51 2nd generation anti-HCV and HCV-RNA positive and matched anti-HCV negative blood donors. The following variables were found to be independently associated with anti-HCV and HCV-RNA positivity: intravenous drug use (IVDU) (p < 0.001), blood transfusion (p < 0.01), tattoos (p < 0.001), previous hospitalization (p < 0.05), history of sexually transmitted disease (STD) (p < 0.001) and lack of travels outside of Europe (p < 0.05). Among the 23 HCV-RNA positive donors without a history of IVDU or blood transfusion, an increased frequency of hospitalization (p = 0.017) and history... (More)
The potential modes of transmission for hepatitis C virus (HCV) infections were studied using a multivariate analysis of risk factor exposure among 51 2nd generation anti-HCV and HCV-RNA positive and matched anti-HCV negative blood donors. The following variables were found to be independently associated with anti-HCV and HCV-RNA positivity: intravenous drug use (IVDU) (p < 0.001), blood transfusion (p < 0.01), tattoos (p < 0.001), previous hospitalization (p < 0.05), history of sexually transmitted disease (STD) (p < 0.001) and lack of travels outside of Europe (p < 0.05). Among the 23 HCV-RNA positive donors without a history of IVDU or blood transfusion, an increased frequency of hospitalization (p = 0.017) and history of STD (p = 0.023) were found. Five of 22 sexual partners of the 51 index blood donors were HCV-RNA positive and in one of these couples sexual transmission was suspected. Anti-HCV and HCV-RNA positive donors were more often seropositive for herpes simplex virus type 2 (HSV-2) antibodies than were HCV-negative controls (p = 0.015). Sexual transmission of HCV may occur, but the possible role of HSV-2 requires further investigation. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Infectious Diseases
volume
27
issue
2
pages
99 - 104
publisher
Taylor & Francis
external identifiers
  • pmid:7544914
  • scopus:0029069399
ISSN
1651-1980
DOI
10.3109/00365549509018987
language
English
LU publication?
yes
id
a2d26d73-8dad-400f-9fd5-e09a96df4ff2 (old id 1108838)
date added to LUP
2016-04-01 16:03:19
date last changed
2025-10-14 13:21:33
@article{a2d26d73-8dad-400f-9fd5-e09a96df4ff2,
  abstract     = {{The potential modes of transmission for hepatitis C virus (HCV) infections were studied using a multivariate analysis of risk factor exposure among 51 2nd generation anti-HCV and HCV-RNA positive and matched anti-HCV negative blood donors. The following variables were found to be independently associated with anti-HCV and HCV-RNA positivity: intravenous drug use (IVDU) (p &lt; 0.001), blood transfusion (p &lt; 0.01), tattoos (p &lt; 0.001), previous hospitalization (p &lt; 0.05), history of sexually transmitted disease (STD) (p &lt; 0.001) and lack of travels outside of Europe (p &lt; 0.05). Among the 23 HCV-RNA positive donors without a history of IVDU or blood transfusion, an increased frequency of hospitalization (p = 0.017) and history of STD (p = 0.023) were found. Five of 22 sexual partners of the 51 index blood donors were HCV-RNA positive and in one of these couples sexual transmission was suspected. Anti-HCV and HCV-RNA positive donors were more often seropositive for herpes simplex virus type 2 (HSV-2) antibodies than were HCV-negative controls (p = 0.015). Sexual transmission of HCV may occur, but the possible role of HSV-2 requires further investigation.}},
  author       = {{Shev, S and Hermodsson, S and Lindholm, A and Malm, E and Widell, Anders and Norkrans, G}},
  issn         = {{1651-1980}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{99--104}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Infectious Diseases}},
  title        = {{Risk factor exposure among hepatitis C virus RNA positive Swedish blood donors--the role of parenteral and sexual transmission}},
  url          = {{http://dx.doi.org/10.3109/00365549509018987}},
  doi          = {{10.3109/00365549509018987}},
  volume       = {{27}},
  year         = {{1995}},
}