Psychiatric treatment in men with prostate cancer - Results from a Nation-wide, population-based cohort study from PCBaSe Sweden
(2011) In European Journal of Cancer 47(14). p.2195-2201- Abstract
- Aim: To explore whether the self-reported psychological distress among men with prostate cancer was to the extent that it required psychiatric treatment. Methods: PCBaSe Sweden, a merged database based on the National Prostate Cancer Register including 97% of all prostate cancers registered as well as age-matched controls. We calculated relative risks and 95% confidence intervals to compare risks of psychiatric treatment due to depression, anxiety, and post-traumatic stress disorder controlling for age and socio-economic factors. We used odds ratios to compare use or no use of antidepressants. Findings: In total 72,613 men with prostate cancer and 217,839 men without prostate cancer were included for analyses. Psychiatric hospitalisation... (More)
- Aim: To explore whether the self-reported psychological distress among men with prostate cancer was to the extent that it required psychiatric treatment. Methods: PCBaSe Sweden, a merged database based on the National Prostate Cancer Register including 97% of all prostate cancers registered as well as age-matched controls. We calculated relative risks and 95% confidence intervals to compare risks of psychiatric treatment due to depression, anxiety, and post-traumatic stress disorder controlling for age and socio-economic factors. We used odds ratios to compare use or no use of antidepressants. Findings: In total 72,613 men with prostate cancer and 217,839 men without prostate cancer were included for analyses. Psychiatric hospitalisation due to depression, anxiety and post-traumatic stress disorder were significantly increased (RR 1.29, (95% CI 1.14-1.45), RR 1.42 (95% CI 1.12-1.80) and RR 1.61 (95% CI 1.16-2.24), respectively). However, hospitalisations due to anxiety were only increased in men with more advanced tumours RR 2.28 (95% CI 1.45-3.57). The use of antidepressants was increased for all men with prostate cancer RR 1.65 (95% CI 1.54-1.77) and treatment strategies RR 1.93 (95% CI 1.75-2.13). Interpretation: Men diagnosed with prostate cancer had increased risk of psychiatric treatment for depression, post-traumatic stress disorder and use of antidepressants regardless of risk group and treatment strategy compared to age-matched controls, whilst more advanced prostate cancer was associated with severe anxiety disorders. (C) 2011 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2211423
- author
- Bill-Axelson, Anna ; Garmo, Hans ; Nyberg, Ullakarin ; Lambe, Mats ; Bratt, Ola LU ; Stattin, Par ; Adolfsson, Jan and Steineck, Gunnar
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Prostate cancer, Depression, Anxiety post-traumatic stress disorder, Androgen deprivation therapy, Cohort study, Population-based
- in
- European Journal of Cancer
- volume
- 47
- issue
- 14
- pages
- 2195 - 2201
- publisher
- Elsevier
- external identifiers
-
- wos:000295768400016
- scopus:80052367175
- pmid:21612913
- ISSN
- 1879-0852
- DOI
- 10.1016/j.ejca.2011.04.022
- language
- English
- LU publication?
- yes
- id
- a31eb20c-20e1-4923-9492-6e2701ae1845 (old id 2211423)
- date added to LUP
- 2016-04-01 10:31:06
- date last changed
- 2022-02-17 18:52:20
@article{a31eb20c-20e1-4923-9492-6e2701ae1845,
abstract = {{Aim: To explore whether the self-reported psychological distress among men with prostate cancer was to the extent that it required psychiatric treatment. Methods: PCBaSe Sweden, a merged database based on the National Prostate Cancer Register including 97% of all prostate cancers registered as well as age-matched controls. We calculated relative risks and 95% confidence intervals to compare risks of psychiatric treatment due to depression, anxiety, and post-traumatic stress disorder controlling for age and socio-economic factors. We used odds ratios to compare use or no use of antidepressants. Findings: In total 72,613 men with prostate cancer and 217,839 men without prostate cancer were included for analyses. Psychiatric hospitalisation due to depression, anxiety and post-traumatic stress disorder were significantly increased (RR 1.29, (95% CI 1.14-1.45), RR 1.42 (95% CI 1.12-1.80) and RR 1.61 (95% CI 1.16-2.24), respectively). However, hospitalisations due to anxiety were only increased in men with more advanced tumours RR 2.28 (95% CI 1.45-3.57). The use of antidepressants was increased for all men with prostate cancer RR 1.65 (95% CI 1.54-1.77) and treatment strategies RR 1.93 (95% CI 1.75-2.13). Interpretation: Men diagnosed with prostate cancer had increased risk of psychiatric treatment for depression, post-traumatic stress disorder and use of antidepressants regardless of risk group and treatment strategy compared to age-matched controls, whilst more advanced prostate cancer was associated with severe anxiety disorders. (C) 2011 Elsevier Ltd. All rights reserved.}},
author = {{Bill-Axelson, Anna and Garmo, Hans and Nyberg, Ullakarin and Lambe, Mats and Bratt, Ola and Stattin, Par and Adolfsson, Jan and Steineck, Gunnar}},
issn = {{1879-0852}},
keywords = {{Prostate cancer; Depression; Anxiety post-traumatic stress disorder; Androgen deprivation therapy; Cohort study; Population-based}},
language = {{eng}},
number = {{14}},
pages = {{2195--2201}},
publisher = {{Elsevier}},
series = {{European Journal of Cancer}},
title = {{Psychiatric treatment in men with prostate cancer - Results from a Nation-wide, population-based cohort study from PCBaSe Sweden}},
url = {{http://dx.doi.org/10.1016/j.ejca.2011.04.022}},
doi = {{10.1016/j.ejca.2011.04.022}},
volume = {{47}},
year = {{2011}},
}