Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

High pro‑neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow‑up

Cimini, Flavia Agata ; Barchetta, Ilaria LU ; Bertoccini, Laura ; Ceccarelli, Valentina ; Baroni, Marco Giorgio ; Melander, Olle LU orcid and Cavallo, Maria Gisella (2022) In Acta Diabetologica 59(1). p.49-56
Abstract
Aims: Neurotensin (NT) is a gut hormone that promotes lipids absorption and controls appetite. Elevated circulating pro-NT, the stable precursor of NT, is associated with cardiovascular (CV) disease, metabolic syndrome (MS) and type 2 diabetes (T2D). Features of MS and insulin resistance are reported also in type 1 diabetes (T1D), with detrimental impact on the overall CV risk profile. Aims of the study were to evaluate plasma pro-NT in T1D patients and to test whether its levels are associated with and/or predictive of CV risk factors and overall risk profile.
Methods: For this longitudinal retrospective study, we analyzed clinical data from 41 T1D individuals referring to the diabetes outpatient clinics at Sapienza University of... (More)
Aims: Neurotensin (NT) is a gut hormone that promotes lipids absorption and controls appetite. Elevated circulating pro-NT, the stable precursor of NT, is associated with cardiovascular (CV) disease, metabolic syndrome (MS) and type 2 diabetes (T2D). Features of MS and insulin resistance are reported also in type 1 diabetes (T1D), with detrimental impact on the overall CV risk profile. Aims of the study were to evaluate plasma pro-NT in T1D patients and to test whether its levels are associated with and/or predictive of CV risk factors and overall risk profile.
Methods: For this longitudinal retrospective study, we analyzed clinical data from 41 T1D individuals referring to the diabetes outpatient clinics at Sapienza University of Rome, Italy, collected at the baseline and after 10 years. Fasting plasma pro-NT levels were measured in T1D subjects at the baseline and in 34 age-, sex-, BMI-comparable healthy individuals recruited in the same period.
Results: Pro-NT did not differ significantly between patients and controls (median[range] pro-NT: 156.3 [96.6-198.2] vs. 179.4 [139.7-230.7] pmol/L, p = 0.26). In T1D, greater fasting pro-NT associated with poor glycemic control at baseline and predicted increased waist circumference, reduced insulin sensitivity, dyslipidemia and hypertension at 10-year follow-up. High pro-NT predicted 10-year very-high CV risk with adjusted OR = 11 (95%C.I.: 1.4-94.5; p = 0.029).
Conclusions: In T1D individuals, elevated pro-NT levels predict the development of adverse metabolic profile, which translates in higher CV risk profile at 10-year follow-up. Pro-NT represents a novel predictor/marker of CV risk factors in adults with T1D. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, Cardiovascular disease, Gastrointestinal peptides, Neuropeptides, Neurotensin, Type 1 Diabetes
in
Acta Diabetologica
volume
59
issue
1
pages
49 - 56
publisher
Springer
external identifiers
  • pmid:34455471
  • scopus:85114026816
ISSN
0940-5429
DOI
10.1007/s00592-021-01783-x
project
AIR Lund - Artificially Intelligent use of Registers
language
English
LU publication?
yes
id
a33a17a1-568f-4b4f-848a-ed0986d721c1
date added to LUP
2021-11-10 14:14:00
date last changed
2024-01-05 18:44:56
@article{a33a17a1-568f-4b4f-848a-ed0986d721c1,
  abstract     = {{Aims: Neurotensin (NT) is a gut hormone that promotes lipids absorption and controls appetite. Elevated circulating pro-NT, the stable precursor of NT, is associated with cardiovascular (CV) disease, metabolic syndrome (MS) and type 2 diabetes (T2D). Features of MS and insulin resistance are reported also in type 1 diabetes (T1D), with detrimental impact on the overall CV risk profile. Aims of the study were to evaluate plasma pro-NT in T1D patients and to test whether its levels are associated with and/or predictive of CV risk factors and overall risk profile.<br/>Methods: For this longitudinal retrospective study, we analyzed clinical data from 41 T1D individuals referring to the diabetes outpatient clinics at Sapienza University of Rome, Italy, collected at the baseline and after 10 years. Fasting plasma pro-NT levels were measured in T1D subjects at the baseline and in 34 age-, sex-, BMI-comparable healthy individuals recruited in the same period.<br/>Results: Pro-NT did not differ significantly between patients and controls (median[range] pro-NT: 156.3 [96.6-198.2] vs. 179.4 [139.7-230.7] pmol/L, p = 0.26). In T1D, greater fasting pro-NT associated with poor glycemic control at baseline and predicted increased waist circumference, reduced insulin sensitivity, dyslipidemia and hypertension at 10-year follow-up. High pro-NT predicted 10-year very-high CV risk with adjusted OR = 11 (95%C.I.: 1.4-94.5; p = 0.029).<br/>Conclusions: In T1D individuals, elevated pro-NT levels predict the development of adverse metabolic profile, which translates in higher CV risk profile at 10-year follow-up. Pro-NT represents a novel predictor/marker of CV risk factors in adults with T1D.}},
  author       = {{Cimini, Flavia Agata and Barchetta, Ilaria and Bertoccini, Laura and Ceccarelli, Valentina and Baroni, Marco Giorgio and Melander, Olle and Cavallo, Maria Gisella}},
  issn         = {{0940-5429}},
  keywords     = {{Biomarkers; Cardiovascular disease; Gastrointestinal peptides; Neuropeptides; Neurotensin; Type 1 Diabetes}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{49--56}},
  publisher    = {{Springer}},
  series       = {{Acta Diabetologica}},
  title        = {{High pro‑neurotensin levels in individuals with type 1 diabetes associate with the development of cardiovascular risk factors at follow‑up}},
  url          = {{http://dx.doi.org/10.1007/s00592-021-01783-x}},
  doi          = {{10.1007/s00592-021-01783-x}},
  volume       = {{59}},
  year         = {{2022}},
}