MHC Class II Supertypes Affect Survival and Lifetime Reproductive Success in a Migratory Songbird
(2024) In Molecular Ecology 33(22).- Abstract
The major histocompatibility complex (MHC) plays a critical role in the immune response against pathogens. Its high polymorphism is thought to be mainly the consequence of host-pathogen co-evolution, but elucidating the mechanism(s) driving MHC evolution remains challenging for natural populations. We investigated the diversity of MHC class II genes in a wild population of pied flycatchers Ficedula hypoleuca and tested its associations with two key components of individual fitness: lifetime reproductive success and survival. Among 180 breeding adults in our study population, we found 182 unique MHC class II exon 2 alleles. The alleles showed a strong signal of positive selection and grouped into nine functional supertypes based on... (More)
The major histocompatibility complex (MHC) plays a critical role in the immune response against pathogens. Its high polymorphism is thought to be mainly the consequence of host-pathogen co-evolution, but elucidating the mechanism(s) driving MHC evolution remains challenging for natural populations. We investigated the diversity of MHC class II genes in a wild population of pied flycatchers Ficedula hypoleuca and tested its associations with two key components of individual fitness: lifetime reproductive success and survival. Among 180 breeding adults in our study population, we found 182 unique MHC class II exon 2 alleles. The alleles showed a strong signal of positive selection and grouped into nine functional supertypes based on physicochemical properties at the inferred antigen-binding sites. Three supertypes were found in > 98% of the sampled individuals, indicating that they are nearly fixed in the population. We found no rare supertypes in the population, as all supertypes were present in > 70% of individuals. Three supertypes were related to different components of individual fitness: two were associated with lower offspring production over time, while the third was positively associated with survival. Overall, the substantial allelic and functional diversity and the relationship between specific supertypes and fitness are in accordance with the notion that balancing selection maintains MHC class II diversity in the study population, possibly with fluctuating selection as the underlying mechanism. The absence of rare supertypes in the population suggests that the balancing selection is not driven by rare-allele advantage.
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- author
- Canal, David ; Roved, Jacob LU ; Lara, Antonio ; Camacho, Carlos LU ; Potti, Jaime and Santoro, Simone
- organization
- publishing date
- 2024-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- balancing selection, fluctuating selection, lifetime reproductive success, major histocompatibility complex, mark–capture–recapture models, MHC supertypes, pied flycatchers, survival
- in
- Molecular Ecology
- volume
- 33
- issue
- 22
- article number
- e17554
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:85207510480
- pmid:39445496
- ISSN
- 0962-1083
- DOI
- 10.1111/mec.17554
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2024 The Author(s). Molecular Ecology published by John Wiley & Sons Ltd.
- id
- a33adcfe-4d41-4175-9c62-52cf3b7139c1
- date added to LUP
- 2024-12-05 13:47:05
- date last changed
- 2024-12-19 15:16:05
@article{a33adcfe-4d41-4175-9c62-52cf3b7139c1,
abstract = {{<p>The major histocompatibility complex (MHC) plays a critical role in the immune response against pathogens. Its high polymorphism is thought to be mainly the consequence of host-pathogen co-evolution, but elucidating the mechanism(s) driving MHC evolution remains challenging for natural populations. We investigated the diversity of MHC class II genes in a wild population of pied flycatchers Ficedula hypoleuca and tested its associations with two key components of individual fitness: lifetime reproductive success and survival. Among 180 breeding adults in our study population, we found 182 unique MHC class II exon 2 alleles. The alleles showed a strong signal of positive selection and grouped into nine functional supertypes based on physicochemical properties at the inferred antigen-binding sites. Three supertypes were found in > 98% of the sampled individuals, indicating that they are nearly fixed in the population. We found no rare supertypes in the population, as all supertypes were present in > 70% of individuals. Three supertypes were related to different components of individual fitness: two were associated with lower offspring production over time, while the third was positively associated with survival. Overall, the substantial allelic and functional diversity and the relationship between specific supertypes and fitness are in accordance with the notion that balancing selection maintains MHC class II diversity in the study population, possibly with fluctuating selection as the underlying mechanism. The absence of rare supertypes in the population suggests that the balancing selection is not driven by rare-allele advantage.</p>}},
author = {{Canal, David and Roved, Jacob and Lara, Antonio and Camacho, Carlos and Potti, Jaime and Santoro, Simone}},
issn = {{0962-1083}},
keywords = {{balancing selection; fluctuating selection; lifetime reproductive success; major histocompatibility complex; mark–capture–recapture models; MHC supertypes; pied flycatchers; survival}},
language = {{eng}},
number = {{22}},
publisher = {{Wiley-Blackwell}},
series = {{Molecular Ecology}},
title = {{MHC Class II Supertypes Affect Survival and Lifetime Reproductive Success in a Migratory Songbird}},
url = {{http://dx.doi.org/10.1111/mec.17554}},
doi = {{10.1111/mec.17554}},
volume = {{33}},
year = {{2024}},
}