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Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Kluth, Oliver ; Stadion, Mandy ; Gottmann, Pascal ; Aga, Heja ; Jähnert, Markus ; Scherneck, Stephan ; Vogel, Heike ; Krus, Ulrika LU ; Seelig, Anett and Ling, Charlotte LU , et al. (2019) In Cell Reports 26(11). p.3-3036
Abstract

Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
beta-cell proliferation, cilia genes, human pancreatic islets, islet transcriptomics, New Zealand Obese mouse, pathway enrichment analysis, primary cilia, type 2 diabetes
in
Cell Reports
volume
26
issue
11
pages
3 - 3036
publisher
Cell Press
external identifiers
  • scopus:85062366876
ISSN
2211-1247
DOI
10.1016/j.celrep.2019.02.056
language
English
LU publication?
yes
id
a341bbfc-1aa6-481e-8530-6d977fe2b970
date added to LUP
2019-03-14 12:41:46
date last changed
2019-11-20 05:39:18
@article{a341bbfc-1aa6-481e-8530-6d977fe2b970,
  abstract     = {<p>Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.</p>},
  author       = {Kluth, Oliver and Stadion, Mandy and Gottmann, Pascal and Aga, Heja and Jähnert, Markus and Scherneck, Stephan and Vogel, Heike and Krus, Ulrika and Seelig, Anett and Ling, Charlotte and Gerdes, Jantje and Schürmann, Annette},
  issn         = {2211-1247},
  language     = {eng},
  number       = {11},
  pages        = {3--3036},
  publisher    = {Cell Press},
  series       = {Cell Reports},
  title        = {Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans},
  url          = {http://dx.doi.org/10.1016/j.celrep.2019.02.056},
  doi          = {10.1016/j.celrep.2019.02.056},
  volume       = {26},
  year         = {2019},
}