Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans
Kluth, Oliver ; Stadion, Mandy ; Gottmann, Pascal ; Aga, Heja ; Jähnert, Markus ; Scherneck, Stephan ; Vogel, Heike ; Krus, Ulrika LU ; Seelig, Anett and Ling, Charlotte LU
, et al.
(2019)
In Cell Reports
26(11).
p.3-3036
- Abstract
Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a341bbfc-1aa6-481e-8530-6d977fe2b970
- author
- Kluth, Oliver
; Stadion, Mandy
; Gottmann, Pascal
; Aga, Heja
; Jähnert, Markus
; Scherneck, Stephan
; Vogel, Heike
; Krus, Ulrika
LU
; Seelig, Anett
and Ling, Charlotte
LU
, et al. (More)
- Kluth, Oliver
; Stadion, Mandy
; Gottmann, Pascal
; Aga, Heja
; Jähnert, Markus
; Scherneck, Stephan
; Vogel, Heike
; Krus, Ulrika
LU
; Seelig, Anett
; Ling, Charlotte
LU
; Gerdes, Jantje
and Schürmann, Annette
(Less)
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- beta-cell proliferation, cilia genes, human pancreatic islets, islet transcriptomics, New Zealand Obese mouse, pathway enrichment analysis, primary cilia, type 2 diabetes
- in
- Cell Reports
- volume
- 26
- issue
- 11
- pages
- 3 - 3036
- publisher
- Cell Press
- external identifiers
-
- scopus:85062366876
- pmid:30865891
- ISSN
- 2211-1247
- DOI
- 10.1016/j.celrep.2019.02.056
- language
- English
- LU publication?
- yes
- id
- a341bbfc-1aa6-481e-8530-6d977fe2b970
- date added to LUP
- 2019-03-14 12:41:46
- date last changed
- 2025-07-25 10:22:00
@article{a341bbfc-1aa6-481e-8530-6d977fe2b970,
abstract = {{<p>Kluth et al. identify a significant enrichment of cilia-annotated genes that are differentially expressed in pancreatic islets of obese mice. Many of the genes were also linked to human T2D, suggesting that dysregulation of cilia-associated genes may participate in T2D risk.</p>}},
author = {{Kluth, Oliver and Stadion, Mandy and Gottmann, Pascal and Aga, Heja and Jähnert, Markus and Scherneck, Stephan and Vogel, Heike and Krus, Ulrika and Seelig, Anett and Ling, Charlotte and Gerdes, Jantje and Schürmann, Annette}},
issn = {{2211-1247}},
keywords = {{beta-cell proliferation; cilia genes; human pancreatic islets; islet transcriptomics; New Zealand Obese mouse; pathway enrichment analysis; primary cilia; type 2 diabetes}},
language = {{eng}},
number = {{11}},
pages = {{3--3036}},
publisher = {{Cell Press}},
series = {{Cell Reports}},
title = {{Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans}},
url = {{http://dx.doi.org/10.1016/j.celrep.2019.02.056}},
doi = {{10.1016/j.celrep.2019.02.056}},
volume = {{26}},
year = {{2019}},
}