Assessment of somatosensory profiles by quantitative sensory testing in children and adolescents with and without cerebral palsy and chronic pain
(2024) In European Journal of Paediatric Neurology 51. p.32-40- Abstract
Objective: We investigated differences in somatosensory profiles (SSPs) assessed by quantitative sensory testing in children and adolescents with cerebral palsy (CCP) with and without chronic pain and compared these differences to those in a group of typically developed children and adolescents (TDC) with and without chronic pain. Method: All included subjects were consecutively recruited from and tested at the same outpatient orthopedic clinic by the same investigator. The subjects had their reaction times tested. The SSP consisted of the following tests: warmth (WDT), cool (CDT), mechanical (MDT), and vibration (VDT) detection thresholds; heat (HPT), pressure (PPT), and mechanical (MPT) pain thresholds; wind-up ratio (WUR); dynamic... (More)
Objective: We investigated differences in somatosensory profiles (SSPs) assessed by quantitative sensory testing in children and adolescents with cerebral palsy (CCP) with and without chronic pain and compared these differences to those in a group of typically developed children and adolescents (TDC) with and without chronic pain. Method: All included subjects were consecutively recruited from and tested at the same outpatient orthopedic clinic by the same investigator. The subjects had their reaction times tested. The SSP consisted of the following tests: warmth (WDT), cool (CDT), mechanical (MDT), and vibration (VDT) detection thresholds; heat (HPT), pressure (PPT), and mechanical (MPT) pain thresholds; wind-up ratio (WUR); dynamic mechanical allodynia (DMA) and cold pressor test (CPT) using a conditioned pain modulation (CPM) paradigm. Results: We included 25 CCP and 26 TDC. TDC without chronic pain served as controls. In TDC with chronic pain, WDT, HPT, HPT intensity, and PPT were higher than in controls. No differences in SSPs between CCP with and without chronic pain were observed. In CCP, the MDT, WDT, CDT, and HPT intensity were higher than in controls. CCP had longer reaction times than TDC. There were no differences regarding the remaining variables. Discussion: In CCP, the SSPs were independent of pain status and findings on MR images. In all CCP the SSPs resembled TDC with chronic pain, compared to TDC without chronic pain. This suggests that CCP do not have the normal neuroplastic adaptive processes that activate and elicit functional changes in the central and peripheral nervous systems.
(Less)
- author
- Jørgensen, Johanne Villars ; Werner, Mads Utke LU ; Michelsen, Josephine Sandahl and Tierp-Wong, Christian Nai En
- organization
- publishing date
- 2024-07
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cerebral palsy, Children and adolescents, Chronic pain, Quantitative sensory testing, Somatosensory profile
- in
- European Journal of Paediatric Neurology
- volume
- 51
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85193988236
- pmid:38795436
- ISSN
- 1090-3798
- DOI
- 10.1016/j.ejpn.2024.05.007
- language
- English
- LU publication?
- yes
- id
- a34775fc-79ea-4750-b299-4fac43454332
- date added to LUP
- 2024-06-03 09:41:35
- date last changed
- 2024-06-17 10:23:33
@article{a34775fc-79ea-4750-b299-4fac43454332,
abstract = {{<p>Objective: We investigated differences in somatosensory profiles (SSPs) assessed by quantitative sensory testing in children and adolescents with cerebral palsy (CCP) with and without chronic pain and compared these differences to those in a group of typically developed children and adolescents (TDC) with and without chronic pain. Method: All included subjects were consecutively recruited from and tested at the same outpatient orthopedic clinic by the same investigator. The subjects had their reaction times tested. The SSP consisted of the following tests: warmth (WDT), cool (CDT), mechanical (MDT), and vibration (VDT) detection thresholds; heat (HPT), pressure (PPT), and mechanical (MPT) pain thresholds; wind-up ratio (WUR); dynamic mechanical allodynia (DMA) and cold pressor test (CPT) using a conditioned pain modulation (CPM) paradigm. Results: We included 25 CCP and 26 TDC. TDC without chronic pain served as controls. In TDC with chronic pain, WDT, HPT, HPT intensity, and PPT were higher than in controls. No differences in SSPs between CCP with and without chronic pain were observed. In CCP, the MDT, WDT, CDT, and HPT intensity were higher than in controls. CCP had longer reaction times than TDC. There were no differences regarding the remaining variables. Discussion: In CCP, the SSPs were independent of pain status and findings on MR images. In all CCP the SSPs resembled TDC with chronic pain, compared to TDC without chronic pain. This suggests that CCP do not have the normal neuroplastic adaptive processes that activate and elicit functional changes in the central and peripheral nervous systems.</p>}},
author = {{Jørgensen, Johanne Villars and Werner, Mads Utke and Michelsen, Josephine Sandahl and Tierp-Wong, Christian Nai En}},
issn = {{1090-3798}},
keywords = {{Cerebral palsy; Children and adolescents; Chronic pain; Quantitative sensory testing; Somatosensory profile}},
language = {{eng}},
pages = {{32--40}},
publisher = {{Elsevier}},
series = {{European Journal of Paediatric Neurology}},
title = {{Assessment of somatosensory profiles by quantitative sensory testing in children and adolescents with and without cerebral palsy and chronic pain}},
url = {{http://dx.doi.org/10.1016/j.ejpn.2024.05.007}},
doi = {{10.1016/j.ejpn.2024.05.007}},
volume = {{51}},
year = {{2024}},
}