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Validation of the PD home diary for assessment of motor fluctuations in advanced Parkinson's disease

Löhle, Matthias ; Bremer, Alexander ; Gandor, Florin ; Timpka, Jonathan LU ; Odin, Per LU orcid ; Ebersbach, Georg and Storch, Alexander (2022) In npj Parkinson's Disease 8(1).
Abstract

The Parkinson's disease (PD) home diary is frequently used in clinical trials to measure efficacy of medical treatments for motor fluctuations in advanced PD. This prospective study in fluctuating PD patients examines the validity of the diary for quantification of motor states in comparison to direct clinical observation. 51 patients (median age: 65 years, disease duration: 11 years) completed the diary half-hourly for two consecutive days and were simultaneously rated by an experienced observer, who independently evaluated motor states half-hourly throughout daytime. Overall agreement (Cohen's kappa) between patient and observer diary entries was 59.8% (0.387). Patients documented more On without dyskinesia (52.3% vs. 38.9%, P <... (More)

The Parkinson's disease (PD) home diary is frequently used in clinical trials to measure efficacy of medical treatments for motor fluctuations in advanced PD. This prospective study in fluctuating PD patients examines the validity of the diary for quantification of motor states in comparison to direct clinical observation. 51 patients (median age: 65 years, disease duration: 11 years) completed the diary half-hourly for two consecutive days and were simultaneously rated by an experienced observer, who independently evaluated motor states half-hourly throughout daytime. Overall agreement (Cohen's kappa) between patient and observer diary entries was 59.8% (0.387). Patients documented more On without dyskinesia (52.3% vs. 38.9%, P < 0.001) and less On with dyskinesia (21.5% vs. 34.2%, P < 0.001), whereas proportions for Off intervals were not different between patient and observer diaries (26.2% vs. 27.0%, P = 0.97). Temporal agreement between diary ratings was unsatisfactory, particularly for On with dyskinesia. Taken together, our study suggests that the PD home diary only inadequately reflects actual motor states compared to direct clinical observation.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
npj Parkinson's Disease
volume
8
issue
1
article number
69
publisher
Springer Nature
external identifiers
  • pmid:35654835
  • scopus:85131213656
ISSN
2373-8057
DOI
10.1038/s41531-022-00331-w
language
English
LU publication?
yes
additional info
© 2022. The Author(s).
id
a34a5b71-52ff-4942-aa6a-625ce2096fc6
date added to LUP
2022-06-08 09:19:24
date last changed
2024-06-16 03:26:20
@article{a34a5b71-52ff-4942-aa6a-625ce2096fc6,
  abstract     = {{<p>The Parkinson's disease (PD) home diary is frequently used in clinical trials to measure efficacy of medical treatments for motor fluctuations in advanced PD. This prospective study in fluctuating PD patients examines the validity of the diary for quantification of motor states in comparison to direct clinical observation. 51 patients (median age: 65 years, disease duration: 11 years) completed the diary half-hourly for two consecutive days and were simultaneously rated by an experienced observer, who independently evaluated motor states half-hourly throughout daytime. Overall agreement (Cohen's kappa) between patient and observer diary entries was 59.8% (0.387). Patients documented more On without dyskinesia (52.3% vs. 38.9%, P &lt; 0.001) and less On with dyskinesia (21.5% vs. 34.2%, P &lt; 0.001), whereas proportions for Off intervals were not different between patient and observer diaries (26.2% vs. 27.0%, P = 0.97). Temporal agreement between diary ratings was unsatisfactory, particularly for On with dyskinesia. Taken together, our study suggests that the PD home diary only inadequately reflects actual motor states compared to direct clinical observation.</p>}},
  author       = {{Löhle, Matthias and Bremer, Alexander and Gandor, Florin and Timpka, Jonathan and Odin, Per and Ebersbach, Georg and Storch, Alexander}},
  issn         = {{2373-8057}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{1}},
  publisher    = {{Springer Nature}},
  series       = {{npj Parkinson's Disease}},
  title        = {{Validation of the PD home diary for assessment of motor fluctuations in advanced Parkinson's disease}},
  url          = {{http://dx.doi.org/10.1038/s41531-022-00331-w}},
  doi          = {{10.1038/s41531-022-00331-w}},
  volume       = {{8}},
  year         = {{2022}},
}