Synaptic vesicle protein 2A as a potential biomarker in synaptopathies
(2019) In Molecular and Cellular Neuroscience 97. p.34-42- Abstract
Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a34c9611-6c2f-4500-8a43-168d29d23ccd
- author
- Heurling, Kerstin ; Ashton, Nicholas J. ; Leuzy, Antoine LU ; Zimmer, Eduardo R. ; Blennow, Kaj LU ; Zetterberg, Henrik LU ; Eriksson, Jonas ; Lubberink, Mark and Schöll, Michael LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Biomarkers, Position emission tomography, SV2A, Synaptopathies
- in
- Molecular and Cellular Neuroscience
- volume
- 97
- pages
- 34 - 42
- publisher
- Elsevier
- external identifiers
-
- pmid:30796959
- scopus:85062658024
- ISSN
- 1044-7431
- DOI
- 10.1016/j.mcn.2019.02.001
- language
- English
- LU publication?
- yes
- id
- a34c9611-6c2f-4500-8a43-168d29d23ccd
- date added to LUP
- 2019-03-19 14:34:29
- date last changed
- 2024-09-03 14:50:56
@article{a34c9611-6c2f-4500-8a43-168d29d23ccd, abstract = {{<p>Measuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have previously been suggested to provide information on pathology and disease status that is complementary to PET-based measures, and the same can be hypothesized with respect to SV2A. This review provides an overview of the current state of SV2A PET imaging as a biomarker of synaptic density, the potential role of fluid-based biomarkers for SV2A, and related future perspectives.</p>}}, author = {{Heurling, Kerstin and Ashton, Nicholas J. and Leuzy, Antoine and Zimmer, Eduardo R. and Blennow, Kaj and Zetterberg, Henrik and Eriksson, Jonas and Lubberink, Mark and Schöll, Michael}}, issn = {{1044-7431}}, keywords = {{Biomarkers; Position emission tomography; SV2A; Synaptopathies}}, language = {{eng}}, pages = {{34--42}}, publisher = {{Elsevier}}, series = {{Molecular and Cellular Neuroscience}}, title = {{Synaptic vesicle protein 2A as a potential biomarker in synaptopathies}}, url = {{http://dx.doi.org/10.1016/j.mcn.2019.02.001}}, doi = {{10.1016/j.mcn.2019.02.001}}, volume = {{97}}, year = {{2019}}, }