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Preservative-free treatment in glaucoma: who, when, and why?

Stalmans, Ingeborg; Megevand, Gordana Sunaric; Cordeiro, M. Francesca; Hommer, Anton; Rossetti, Luca; Goni, Francisco; Heijl, Anders LU and Bron, Alain (2013) In European Journal of Ophthalmology 23(4). p.518-525
Abstract
Purpose: To review and summarize the available literature on the effect of preservatives on the eye, to provide practical guidance for the clinical assessment of the ocular surface in glaucoma patients, and to define patient populations that might benefit from preservative-free topical intraocular pressure (IOP)-lowering agents. Methods: This manuscript is based on a combination of a literature review on preservatives and the eye and expert opinion from glaucoma specialists with an interest in ocular surface disease. Results: There is an increasingly recognized association between eyedrop preservatives and ocular surface disease. Preservative-free therapy is now available for a wide range of active compounds, although there are still some... (More)
Purpose: To review and summarize the available literature on the effect of preservatives on the eye, to provide practical guidance for the clinical assessment of the ocular surface in glaucoma patients, and to define patient populations that might benefit from preservative-free topical intraocular pressure (IOP)-lowering agents. Methods: This manuscript is based on a combination of a literature review on preservatives and the eye and expert opinion from glaucoma specialists with an interest in ocular surface disease. Results: There is an increasingly recognized association between eyedrop preservatives and ocular surface disease. Preservative-free therapy is now available for a wide range of active compounds, although there are still some misconceptions regarding their appropriate use. For patients treated topically for glaucoma or ocular hypertension, a rough estimate could be that 20% may need treatment with topical IOP-reducing agents that are free from preservatives. Conclusions: This review provides an up-to-date account of the literature regarding preservatives and the eye, as well as suggestions and recommendations on to when to use preservative-free antiglaucoma treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Glaucoma, Intraocular pressure-lowering agents, Ocular surface, Preservative
in
European Journal of Ophthalmology
volume
23
issue
4
pages
518 - 525
publisher
Wichtig Editore
external identifiers
  • wos:000324152400009
  • scopus:84878470760
ISSN
1120-6721
DOI
10.5301/ejo.5000270
language
English
LU publication?
yes
id
a35a8938-43cb-46de-ad13-fd8cb0e789ec (old id 4103268)
date added to LUP
2013-11-07 14:20:59
date last changed
2019-04-10 01:01:03
@article{a35a8938-43cb-46de-ad13-fd8cb0e789ec,
  abstract     = {Purpose: To review and summarize the available literature on the effect of preservatives on the eye, to provide practical guidance for the clinical assessment of the ocular surface in glaucoma patients, and to define patient populations that might benefit from preservative-free topical intraocular pressure (IOP)-lowering agents. Methods: This manuscript is based on a combination of a literature review on preservatives and the eye and expert opinion from glaucoma specialists with an interest in ocular surface disease. Results: There is an increasingly recognized association between eyedrop preservatives and ocular surface disease. Preservative-free therapy is now available for a wide range of active compounds, although there are still some misconceptions regarding their appropriate use. For patients treated topically for glaucoma or ocular hypertension, a rough estimate could be that 20% may need treatment with topical IOP-reducing agents that are free from preservatives. Conclusions: This review provides an up-to-date account of the literature regarding preservatives and the eye, as well as suggestions and recommendations on to when to use preservative-free antiglaucoma treatment.},
  author       = {Stalmans, Ingeborg and Megevand, Gordana Sunaric and Cordeiro, M. Francesca and Hommer, Anton and Rossetti, Luca and Goni, Francisco and Heijl, Anders and Bron, Alain},
  issn         = {1120-6721},
  keyword      = {Glaucoma,Intraocular pressure-lowering agents,Ocular surface,Preservative},
  language     = {eng},
  number       = {4},
  pages        = {518--525},
  publisher    = {Wichtig Editore},
  series       = {European Journal of Ophthalmology},
  title        = {Preservative-free treatment in glaucoma: who, when, and why?},
  url          = {http://dx.doi.org/10.5301/ejo.5000270},
  volume       = {23},
  year         = {2013},
}