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Permeability of subcutaneous tissues surrounding long-term implants to oxygen

Kumosa, Lucas LU ; Routh, Timothy; Lin, Joe; Lucisano, Joseph and Gough, David (2014) In Biomaterials 35(29). p.8287-8296
Abstract
Certain types of implanted medical devices depend on oxygen supplied from surrounding tissues for their function. However, there is a concern that the tissue associated with the foreign body response to implants may become impermeable to oxygen over the long term and render the implant nonfunctional. We report oxygen flux recordings from electrochemical oxygen sensor devices with wireless telemetry implanted in subcutaneous porcine tissues. The devices remained implanted for up to 13 weeks and were removed with adjacent tissues at specified times for histologic examination. There are four main observations: (1) In the first few weeks after implantation, the oxygen flux to the sensors, or current density, declined to a sustained mean value,... (More)
Certain types of implanted medical devices depend on oxygen supplied from surrounding tissues for their function. However, there is a concern that the tissue associated with the foreign body response to implants may become impermeable to oxygen over the long term and render the implant nonfunctional. We report oxygen flux recordings from electrochemical oxygen sensor devices with wireless telemetry implanted in subcutaneous porcine tissues. The devices remained implanted for up to 13 weeks and were removed with adjacent tissues at specified times for histologic examination. There are four main observations: (1) In the first few weeks after implantation, the oxygen flux to the sensors, or current density, declined to a sustained mean value, having unsynchronized cyclic variations around the mean; (2) The oxygen mass transfer resistance of the sensor membrane was negligible compared to that of the tissue, allowing for a sensitive estimate of the tissue permeability; (3) The effective diffusion coefficient of oxygen in tissues was found to be approximately one order of magnitude lower than in water; and (4) Quantitative histologic analysis of the tissues showed a mild foreign body response to the PDMS sensor membrane material, with capillaries positioned close to the implant surface. Continuous recordings of oxygen flux indicate that the tissue permeability changes predictably with time, and suggest that oxygen delivery can be sustained over the long term. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomaterials
volume
35
issue
29
pages
8287 - 8296
publisher
Elsevier
external identifiers
  • scopus:84904114588
ISSN
1878-5905
DOI
10.1016/j.biomaterials.2014.05.012
language
English
LU publication?
no
id
a35eca0b-f127-42d2-93fc-80efd63e530e
date added to LUP
2017-06-23 10:44:13
date last changed
2017-10-08 05:03:33
@article{a35eca0b-f127-42d2-93fc-80efd63e530e,
  abstract     = {Certain types of implanted medical devices depend on oxygen supplied from surrounding tissues for their function. However, there is a concern that the tissue associated with the foreign body response to implants may become impermeable to oxygen over the long term and render the implant nonfunctional. We report oxygen flux recordings from electrochemical oxygen sensor devices with wireless telemetry implanted in subcutaneous porcine tissues. The devices remained implanted for up to 13 weeks and were removed with adjacent tissues at specified times for histologic examination. There are four main observations: (1) In the first few weeks after implantation, the oxygen flux to the sensors, or current density, declined to a sustained mean value, having unsynchronized cyclic variations around the mean; (2) The oxygen mass transfer resistance of the sensor membrane was negligible compared to that of the tissue, allowing for a sensitive estimate of the tissue permeability; (3) The effective diffusion coefficient of oxygen in tissues was found to be approximately one order of magnitude lower than in water; and (4) Quantitative histologic analysis of the tissues showed a mild foreign body response to the PDMS sensor membrane material, with capillaries positioned close to the implant surface. Continuous recordings of oxygen flux indicate that the tissue permeability changes predictably with time, and suggest that oxygen delivery can be sustained over the long term. },
  author       = {Kumosa, Lucas and Routh, Timothy and Lin, Joe and Lucisano, Joseph and Gough, David},
  issn         = {1878-5905},
  language     = {eng},
  month        = {07},
  number       = {29},
  pages        = {8287--8296},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {Permeability of subcutaneous tissues surrounding long-term implants to oxygen},
  url          = {http://dx.doi.org/10.1016/j.biomaterials.2014.05.012},
  volume       = {35},
  year         = {2014},
}