Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Applying genetic technologies to combat infectious diseases in aquaculture

Robinson, Nicholas A. ; Robledo, Diego ; Sveen, Lene ; Daniels, Rose Ruiz ; Krasnov, Aleksei ; Coates, Andrew ; Barrett, Luke T. ; Lillehammer, Marie ; Kettunen, Anne H. and Phillips, Ben L. , et al. (2023) In Reviews in Aquaculture 15(2). p.491-535
Abstract

Disease and parasitism cause major welfare, environmental and economic concerns for global aquaculture. In this review, we examine the status and potential of technologies that exploit genetic variation in host resistance to tackle this problem. We argue that there is an urgent need to improve understanding of the genetic mechanisms involved, leading to the development of tools that can be applied to boost host resistance and reduce the disease burden. We draw on two pressing global disease problems as case studies—sea lice infestations in salmonids and white spot syndrome in shrimp. We review how the latest genetic technologies can be capitalised upon to determine the mechanisms underlying inter- and intra-species variation in... (More)

Disease and parasitism cause major welfare, environmental and economic concerns for global aquaculture. In this review, we examine the status and potential of technologies that exploit genetic variation in host resistance to tackle this problem. We argue that there is an urgent need to improve understanding of the genetic mechanisms involved, leading to the development of tools that can be applied to boost host resistance and reduce the disease burden. We draw on two pressing global disease problems as case studies—sea lice infestations in salmonids and white spot syndrome in shrimp. We review how the latest genetic technologies can be capitalised upon to determine the mechanisms underlying inter- and intra-species variation in pathogen/parasite resistance, and how the derived knowledge could be applied to boost disease resistance using selective breeding, gene editing and/or with targeted feed treatments and vaccines. Gene editing brings novel opportunities, but also implementation and dissemination challenges, and necessitates new protocols to integrate the technology into aquaculture breeding programmes. There is also an ongoing need to minimise risks of disease agents evolving to overcome genetic improvements to host resistance, and insights from epidemiological and evolutionary models of pathogen infestation in wild and cultured host populations are explored. Ethical issues around the different approaches for achieving genetic resistance are discussed. Application of genetic technologies and approaches has potential to improve fundamental knowledge of mechanisms affecting genetic resistance and provide effective pathways for implementation that could lead to more resistant aquaculture stocks, transforming global aquaculture.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
keywords
gene editing, genomic selection, host resistance, sea lice, transcriptomics, white-spot syndrome virus
in
Reviews in Aquaculture
volume
15
issue
2
pages
491 - 535
publisher
Wiley
external identifiers
  • scopus:85137382892
  • pmid:38504717
ISSN
1753-5123
DOI
10.1111/raq.12733
language
English
LU publication?
no
additional info
Funding Information: This review was funded from our projects with the short titles ‘CrispResist’ funded by the Norwegian Seafood Research Fund (FHF, project 901631), ‘NoLice’ and GenomResist’ funded by the Norwegian Research Council (projects 320619 and 244131 respectively) and ‘GenoLice’ funded by the Biotechnology and Biological Sciences Research Council of the UK. We also thank our industry partners Benchmark Genetics, Mowi, Salmar, the Sustainable Aquaculture Innovation Centre, Centre for Aquaculture Technologies Canada and Cargill for their contributions of knowledge, time, animals and resources to these projects. Funding Information: This review was funded from our projects with the short titles ‘CrispResist’ funded by the Norwegian Seafood Research Fund (FHF, project 901631), ‘NoLice’ and GenomResist’ funded by the Norwegian Research Council (projects 320619 and 244131 respectively) and ‘GenoLice’ funded by the Biotechnology and Biological Sciences Research Council of the UK. We also thank our industry partners Benchmark Genetics, Mowi, Salmar, the Sustainable Aquaculture Innovation Centre, Centre for Aquaculture Technologies Canada and Cargill for their contributions of knowledge, time, animals and resources to these projects. Publisher Copyright: © 2022 The Authors. Reviews in Aquaculture published by John Wiley & Sons Australia, Ltd.
id
a3652021-6cb5-4299-bcef-2ad0259e2c03
date added to LUP
2023-05-31 09:32:03
date last changed
2024-12-15 23:12:36
@article{a3652021-6cb5-4299-bcef-2ad0259e2c03,
  abstract     = {{<p>Disease and parasitism cause major welfare, environmental and economic concerns for global aquaculture. In this review, we examine the status and potential of technologies that exploit genetic variation in host resistance to tackle this problem. We argue that there is an urgent need to improve understanding of the genetic mechanisms involved, leading to the development of tools that can be applied to boost host resistance and reduce the disease burden. We draw on two pressing global disease problems as case studies—sea lice infestations in salmonids and white spot syndrome in shrimp. We review how the latest genetic technologies can be capitalised upon to determine the mechanisms underlying inter- and intra-species variation in pathogen/parasite resistance, and how the derived knowledge could be applied to boost disease resistance using selective breeding, gene editing and/or with targeted feed treatments and vaccines. Gene editing brings novel opportunities, but also implementation and dissemination challenges, and necessitates new protocols to integrate the technology into aquaculture breeding programmes. There is also an ongoing need to minimise risks of disease agents evolving to overcome genetic improvements to host resistance, and insights from epidemiological and evolutionary models of pathogen infestation in wild and cultured host populations are explored. Ethical issues around the different approaches for achieving genetic resistance are discussed. Application of genetic technologies and approaches has potential to improve fundamental knowledge of mechanisms affecting genetic resistance and provide effective pathways for implementation that could lead to more resistant aquaculture stocks, transforming global aquaculture.</p>}},
  author       = {{Robinson, Nicholas A. and Robledo, Diego and Sveen, Lene and Daniels, Rose Ruiz and Krasnov, Aleksei and Coates, Andrew and Barrett, Luke T. and Lillehammer, Marie and Kettunen, Anne H. and Phillips, Ben L. and Dempster, Tim and Doeschl-Wilson, Andrea and Samsing, Francisca and Difford, Gareth and Salisbury, Sarah and Gjerde, Bjarne and Haugen, John Erik and Burgerhout, Erik and Dagnachew, Binyam S. and Kurian, Dominic and Fast, Mark D. and Rye, Morten and Salazar, Marcela and Bron, James E. and Monaghan, Sean J. and Jacq, Celeste and Birkett, Mike and Browman, Howard I. and Skiftesvik, Anne Berit and Fields, David M. and Selander, Erik and Bui, Samantha and Sonesson, Anna and Skugor, Stanko and Østbye, Tone Kari Knutsdatter and Houston, Ross D.}},
  issn         = {{1753-5123}},
  keywords     = {{gene editing; genomic selection; host resistance; sea lice; transcriptomics; white-spot syndrome virus}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{491--535}},
  publisher    = {{Wiley}},
  series       = {{Reviews in Aquaculture}},
  title        = {{Applying genetic technologies to combat infectious diseases in aquaculture}},
  url          = {{http://dx.doi.org/10.1111/raq.12733}},
  doi          = {{10.1111/raq.12733}},
  volume       = {{15}},
  year         = {{2023}},
}