Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment
(2018) In Oxidative Medicine and Cellular Longevity 2018. p.1821359-1821359- Abstract
Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y, diabetic rats treated with YLE. Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40 mg-1/kg body weight, single dose, i.p.), and treated groups received 100 mg/kg body weight YLE daily via gavage for 30 d. The YLE group shows an improvement in dysmetabolism and cardiomyopathy in the diabetic condition (DM versus DM + Y) promoting a significant reduction of glycemia by 63.39%, an increase in... (More)
Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y, diabetic rats treated with YLE. Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40 mg-1/kg body weight, single dose, i.p.), and treated groups received 100 mg/kg body weight YLE daily via gavage for 30 d. The YLE group shows an improvement in dysmetabolism and cardiomyopathy in the diabetic condition (DM versus DM + Y) promoting a significant reduction of glycemia by 63.39%, an increase in insulin concentration by 49.30%, and a decrease in serum triacylglycerol and fatty acid contents by 0.39- and 0.43-fold, respectively, by ameliorating the pancreatic islet injury, as well as increasing the activity of the antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and decreasing the fibrosis and cellular disorganization in cardiac tissue. The apparent benefits of YLE seem to be mediated by ameliorating dysmetabolism and oxidative stress in pancreatic and cardiac tissues.
(Less)
- author
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Antioxidants/metabolism, Asteraceae/chemistry, Atrial Remodeling/drug effects, Blood Glucose/drug effects, Diabetes Mellitus, Experimental/drug therapy, Immunohistochemistry, Islets of Langerhans/drug effects, Male, Malondialdehyde/blood, Plant Extracts/chemistry, Plant Leaves/chemistry, Rats, Rats, Wistar, Superoxide Dismutase/metabolism, Triglycerides/blood
- in
- Oxidative Medicine and Cellular Longevity
- volume
- 2018
- pages
- 1821359 - 1821359
- publisher
- Hindawi Limited
- external identifiers
-
- scopus:85055152453
- pmid:30057670
- ISSN
- 1942-0900
- DOI
- 10.1155/2018/1821359
- language
- English
- LU publication?
- no
- id
- a373a428-72b6-47e1-8c22-5b4be6661e72
- date added to LUP
- 2019-03-28 18:16:29
- date last changed
- 2024-10-01 19:10:43
@article{a373a428-72b6-47e1-8c22-5b4be6661e72,
abstract = {{<p>Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C + Y, controls treated with Yacon leaf extract (YLE); DM, diabetic controls; and DM + Y, diabetic rats treated with YLE. Type 1 diabetes (T1DM) was induced by the administration of streptozotocin (STZ; 40 mg-1/kg body weight, single dose, i.p.), and treated groups received 100 mg/kg body weight YLE daily via gavage for 30 d. The YLE group shows an improvement in dysmetabolism and cardiomyopathy in the diabetic condition (DM versus DM + Y) promoting a significant reduction of glycemia by 63.39%, an increase in insulin concentration by 49.30%, and a decrease in serum triacylglycerol and fatty acid contents by 0.39- and 0.43-fold, respectively, by ameliorating the pancreatic islet injury, as well as increasing the activity of the antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) and decreasing the fibrosis and cellular disorganization in cardiac tissue. The apparent benefits of YLE seem to be mediated by ameliorating dysmetabolism and oxidative stress in pancreatic and cardiac tissues.</p>}},
author = {{Dos Santos, Klinsmann Carolo and Cury, Sarah Santiloni and Ferraz, Ana Paula Costa Rodrigues and Corrente, José Eduardo and Gonçalves, Bianca Mariani and de Araújo Machado, Luiz Henrique and Carvalho, Robson Francisco and de Melo Stevanato Nakamune, Ana Cláudia and Fabro, Alexandre Todorovic and Freire, Paula Paccielli and Corrêa, Camila Renata}},
issn = {{1942-0900}},
keywords = {{Animals; Antioxidants/metabolism; Asteraceae/chemistry; Atrial Remodeling/drug effects; Blood Glucose/drug effects; Diabetes Mellitus, Experimental/drug therapy; Immunohistochemistry; Islets of Langerhans/drug effects; Male; Malondialdehyde/blood; Plant Extracts/chemistry; Plant Leaves/chemistry; Rats; Rats, Wistar; Superoxide Dismutase/metabolism; Triglycerides/blood}},
language = {{eng}},
pages = {{1821359--1821359}},
publisher = {{Hindawi Limited}},
series = {{Oxidative Medicine and Cellular Longevity}},
title = {{Recovery of Cardiac Remodeling and Dysmetabolism by Pancreatic Islet Injury Improvement in Diabetic Rats after Yacon Leaf Extract Treatment}},
url = {{http://dx.doi.org/10.1155/2018/1821359}},
doi = {{10.1155/2018/1821359}},
volume = {{2018}},
year = {{2018}},
}