Specificity of leucine stimulation of insulin release
Lernmark LU
(1972)
In Hormone Research in Paediatrics
3(1).
p.14-21
- Abstract
The ability of leucine to stimulate insulin release was studied in an in vitro system, using microdissected pancreatic islets with a high proportion of the insulin-producing β-cells. When tested in a glucose-free medium, l-leucine stimulated insulin release over a wide concentration range with maximum effect at about 20 mm. The stimulation of insulin release was additive to that elicited by 10 mm glucose. The l-configuration was essential for leucine to be recognized by the β-cells as an insulin secretagogue. l-isoleucine, alone or in combination with l-leucine, did not affect insulin release. It seems, therefore, unlikely that all sites for l-leucine transport are identical with receptor sites for stimulation of insulin release.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a389fc66-c108-4d08-b956-7c1f2da57b56
- author
- Lernmark
LU
- publishing date
- 1972-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- D-leucine, Insulin release, Isolated islets, L-isoleucine, L-leucine, Pancreatic β-cells, Receptor sites, Transport sites
- in
- Hormone Research in Paediatrics
- volume
- 3
- issue
- 1
- pages
- 8 pages
- publisher
- Karger
- external identifiers
-
- pmid:4347545
- scopus:0015442123
- ISSN
- 1663-2818
- DOI
- 10.1159/000178253
- language
- English
- LU publication?
- no
- id
- a389fc66-c108-4d08-b956-7c1f2da57b56
- date added to LUP
- 2019-12-12 23:36:57
- date last changed
- 2025-10-14 11:15:13
@article{a389fc66-c108-4d08-b956-7c1f2da57b56,
abstract = {{<p>The ability of leucine to stimulate insulin release was studied in an in vitro system, using microdissected pancreatic islets with a high proportion of the insulin-producing β-cells. When tested in a glucose-free medium, l-leucine stimulated insulin release over a wide concentration range with maximum effect at about 20 mm. The stimulation of insulin release was additive to that elicited by 10 mm glucose. The l-configuration was essential for leucine to be recognized by the β-cells as an insulin secretagogue. l-isoleucine, alone or in combination with l-leucine, did not affect insulin release. It seems, therefore, unlikely that all sites for l-leucine transport are identical with receptor sites for stimulation of insulin release.</p>}},
author = {{Lernmark}},
issn = {{1663-2818}},
keywords = {{D-leucine; Insulin release; Isolated islets; L-isoleucine; L-leucine; Pancreatic β-cells; Receptor sites; Transport sites}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{14--21}},
publisher = {{Karger}},
series = {{Hormone Research in Paediatrics}},
title = {{Specificity of leucine stimulation of insulin release}},
url = {{http://dx.doi.org/10.1159/000178253}},
doi = {{10.1159/000178253}},
volume = {{3}},
year = {{1972}},
}