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Adenovirous type 9-induced tumorigenesis in the rat mammary gland related to sex hormonal state

Ankerst, Jaro LU orcid and Jonsson, Nils LU (1989) In Journal of the National Cancer Institute 81(4). p.294-298
Abstract

Adenovirus type 9 was inoculated sc into newborn Wistar/Furth rats, divided into four groups: (1) six male rats, not treated further; (2) 11 male rats, castrated at 4 weeks of age; (3) 12 male rats, castrated at 4 weeks of age and subsequently treated repeatedly with estrogen; and (4) 12 female rats, not treated further. All of the rats in group 3 developed mammary hyperplasia and tumors (fibroadenomas and lipomas), in some cases with malignant histologic structure. Rats in group 4 developed similar mammary tumors, but with later appearance and significantly slower growth. A fifth group of rats, not virus inoculated but castrated and estrogen treated as in group 3, did not develop any demonstrable mammary lesions. The results show that... (More)

Adenovirus type 9 was inoculated sc into newborn Wistar/Furth rats, divided into four groups: (1) six male rats, not treated further; (2) 11 male rats, castrated at 4 weeks of age; (3) 12 male rats, castrated at 4 weeks of age and subsequently treated repeatedly with estrogen; and (4) 12 female rats, not treated further. All of the rats in group 3 developed mammary hyperplasia and tumors (fibroadenomas and lipomas), in some cases with malignant histologic structure. Rats in group 4 developed similar mammary tumors, but with later appearance and significantly slower growth. A fifth group of rats, not virus inoculated but castrated and estrogen treated as in group 3, did not develop any demonstrable mammary lesions. The results show that the effects of the virus on the mammary gland are dependent upon an estrogenic background, which by itself cannot cause tumor development in males. It is suggested that viral DNA is incorporated into the cellular DNA in such a way that it influences the synthesis and/or activity of steroid receptors, triggering tumor development.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the National Cancer Institute
volume
81
issue
4
pages
294 - 298
publisher
Oxford University Press
external identifiers
  • scopus:0024505068
  • pmid:2913327
ISSN
0027-8874
DOI
10.1093/jnci/81.4.294
language
English
LU publication?
yes
id
a394d1dc-8162-4059-b49d-5c686455ce21
date added to LUP
2020-12-29 17:00:05
date last changed
2024-04-18 01:35:21
@article{a394d1dc-8162-4059-b49d-5c686455ce21,
  abstract     = {{<p>Adenovirus type 9 was inoculated sc into newborn Wistar/Furth rats, divided into four groups: (1) six male rats, not treated further; (2) 11 male rats, castrated at 4 weeks of age; (3) 12 male rats, castrated at 4 weeks of age and subsequently treated repeatedly with estrogen; and (4) 12 female rats, not treated further. All of the rats in group 3 developed mammary hyperplasia and tumors (fibroadenomas and lipomas), in some cases with malignant histologic structure. Rats in group 4 developed similar mammary tumors, but with later appearance and significantly slower growth. A fifth group of rats, not virus inoculated but castrated and estrogen treated as in group 3, did not develop any demonstrable mammary lesions. The results show that the effects of the virus on the mammary gland are dependent upon an estrogenic background, which by itself cannot cause tumor development in males. It is suggested that viral DNA is incorporated into the cellular DNA in such a way that it influences the synthesis and/or activity of steroid receptors, triggering tumor development.</p>}},
  author       = {{Ankerst, Jaro and Jonsson, Nils}},
  issn         = {{0027-8874}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{294--298}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of the National Cancer Institute}},
  title        = {{Adenovirous type 9-induced tumorigenesis in the rat mammary gland related to sex hormonal state}},
  url          = {{http://dx.doi.org/10.1093/jnci/81.4.294}},
  doi          = {{10.1093/jnci/81.4.294}},
  volume       = {{81}},
  year         = {{1989}},
}