Etiology and pathogenesis of parkinson’s disease
Timpka, Jonathan LU ; Cenci, Maria Angela LU
and Odin, Per
LU
(2017)
p.95-101
- Abstract
The etiology of Parkinson’s disease (PD) is still far from fully known. In the new millennium, an increased knowledge of the genetic forms of PD has contributed to an improved understanding of underlying cellular mechanisms that are central also in sporadic PD. Although steadily improving, the challenge to fully understand the origin, function, and consequences of Lewy bodies still remains. Toxicological or viral exposure has been hypothesized to function as stressors that, together with a genetic susceptibility, precipitate the development of PD. Meanwhile the impact of these environmental factors is somewhat controversial, it is clear that old age is the single most important risk factor for PD. The improved access to molecular... (More)
The etiology of Parkinson’s disease (PD) is still far from fully known. In the new millennium, an increased knowledge of the genetic forms of PD has contributed to an improved understanding of underlying cellular mechanisms that are central also in sporadic PD. Although steadily improving, the challenge to fully understand the origin, function, and consequences of Lewy bodies still remains. Toxicological or viral exposure has been hypothesized to function as stressors that, together with a genetic susceptibility, precipitate the development of PD. Meanwhile the impact of these environmental factors is somewhat controversial, it is clear that old age is the single most important risk factor for PD. The improved access to molecular genetic methods has, as in many fields of medicine, reformed PD research, and this is likely where the most significant progress will be made in the near future. Due to the heterogeneous clinical features within the PD entity and the similarities to several closely related diseases, it is reasonable to take into consideration that what is today defined as PD may not be one disease, but rather several diseases with similar clinical features.
(Less)
- author
- Timpka, Jonathan
LU
; Cenci, Maria Angela
LU
and Odin, Per
LU
- organization
- publishing date
- 2017
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Etiology, Lewy bodies, Parkinson’s disease, Pathogenesis, Risk factors
- host publication
- Movement Disorders Curricula
- pages
- 7 pages
- publisher
- Springer
- external identifiers
-
- scopus:85086982256
- ISBN
- 9783709116272
- 9783709116289
- DOI
- 10.1007/978-3-7091-1628-9_10
- language
- English
- LU publication?
- yes
- id
- a402400c-470a-47b4-b9a5-a6a953684bd5
- date added to LUP
- 2020-07-14 09:32:50
- date last changed
- 2024-02-16 19:55:20
@inbook{a402400c-470a-47b4-b9a5-a6a953684bd5,
abstract = {{<p>The etiology of Parkinson’s disease (PD) is still far from fully known. In the new millennium, an increased knowledge of the genetic forms of PD has contributed to an improved understanding of underlying cellular mechanisms that are central also in sporadic PD. Although steadily improving, the challenge to fully understand the origin, function, and consequences of Lewy bodies still remains. Toxicological or viral exposure has been hypothesized to function as stressors that, together with a genetic susceptibility, precipitate the development of PD. Meanwhile the impact of these environmental factors is somewhat controversial, it is clear that old age is the single most important risk factor for PD. The improved access to molecular genetic methods has, as in many fields of medicine, reformed PD research, and this is likely where the most significant progress will be made in the near future. Due to the heterogeneous clinical features within the PD entity and the similarities to several closely related diseases, it is reasonable to take into consideration that what is today defined as PD may not be one disease, but rather several diseases with similar clinical features.</p>}},
author = {{Timpka, Jonathan and Cenci, Maria Angela and Odin, Per}},
booktitle = {{Movement Disorders Curricula}},
isbn = {{9783709116272}},
keywords = {{Etiology; Lewy bodies; Parkinson’s disease; Pathogenesis; Risk factors}},
language = {{eng}},
pages = {{95--101}},
publisher = {{Springer}},
title = {{Etiology and pathogenesis of parkinson’s disease}},
url = {{http://dx.doi.org/10.1007/978-3-7091-1628-9_10}},
doi = {{10.1007/978-3-7091-1628-9_10}},
year = {{2017}},
}