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Microbial Translocation Correlates with the Severity of Both HIV-1 and HIV-2 Infections

Nowroozalizadeh, Salma ; Månsson, Fredrik LU ; da Silva, Zacarias ; Repits, Johanna LU ; Dabo, Braima ; Pereira, Carla ; Biague, Antonio ; Albert, Jan ; Nielsen, Jens and Aaby, Peter , et al. (2010) 5th Smögen Symposium on Virology In Journal of Infectious Diseases 201(8). p.1150-1154
Abstract
Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both... (More)
Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections. (Less)
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publication status
published
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in
Journal of Infectious Diseases
volume
201
issue
8
pages
1150 - 1154
publisher
Oxford University Press
conference name
5th Smögen Symposium on Virology
conference location
Smögen, Sweden
conference dates
2009-08-20 - 2009-08-22
external identifiers
  • wos:000275493400007
  • scopus:77950267769
  • pmid:20199244
ISSN
1537-6613
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Medical Microbiology (013250400), Infectious Diseases Research Unit (013242010), Division of Infection Medicine (SUS) (013008000)
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a40f3715-426d-4906-b83f-5088c58c50e3 (old id 1588349)
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https://www.jstor.org/stable/pdf/40599263.pdf
date added to LUP
2016-04-01 12:55:17
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2020-03-11 06:46:25
@article{a40f3715-426d-4906-b83f-5088c58c50e3,
  abstract     = {Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4(+) T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4(+) T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections.},
  author       = {Nowroozalizadeh, Salma and Månsson, Fredrik and da Silva, Zacarias and Repits, Johanna and Dabo, Braima and Pereira, Carla and Biague, Antonio and Albert, Jan and Nielsen, Jens and Aaby, Peter and Fenyö, Eva Maria and Norrgren, Hans and Holmgren, Birgitta G and Jansson, Marianne},
  issn         = {1537-6613},
  language     = {eng},
  number       = {8},
  pages        = {1150--1154},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Microbial Translocation Correlates with the Severity of Both HIV-1 and HIV-2 Infections},
  url          = {https://www.jstor.org/stable/pdf/40599263.pdf},
  volume       = {201},
  year         = {2010},
}