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Poly(3-hydroxyalkanoate)s : Diversification and biomedical applications: A state of the art review

Hazer, Derya Burcu LU orcid ; Kiliçay, Ebru and Hazer, Baki (2012) In Materials Science and Engineering C 32(4). p.637-647
Abstract

Biomaterials have played an important role in the treatment of disease and the improvement of health care. Synthetic and naturally occurring biodegradable and biocompatible polymers have been used as biomaterials. Polyhydroxyalkanoates (PHAs) are promising materials for biomedical applications because they are biodegradable, non-toxic and biocompatible. We will shortly summarize the modification reactions, which include functionalization and grafting reactions, to improve the mechanical, thermal and hydrophilic properties of PHAs. The use of the modified PHAs in numerous biomedical applications, such as sutures, cardiovascular patches, wound dressings, scaffolds in tissue engineering, tissue repair/regeneration devices, drug carriers... (More)

Biomaterials have played an important role in the treatment of disease and the improvement of health care. Synthetic and naturally occurring biodegradable and biocompatible polymers have been used as biomaterials. Polyhydroxyalkanoates (PHAs) are promising materials for biomedical applications because they are biodegradable, non-toxic and biocompatible. We will shortly summarize the modification reactions, which include functionalization and grafting reactions, to improve the mechanical, thermal and hydrophilic properties of PHAs. The use of the modified PHAs in numerous biomedical applications, such as sutures, cardiovascular patches, wound dressings, scaffolds in tissue engineering, tissue repair/regeneration devices, drug carriers will be discussed in this review.

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Please use this url to cite or link to this publication:
author
; and
publishing date
type
Contribution to journal
publication status
published
keywords
Biocompatibility, Biomaterials, Medical applications, Microbial polyester, Poly(3-hydroxy alkanoate)
in
Materials Science and Engineering C
volume
32
issue
4
pages
637 - 647
publisher
Elsevier
external identifiers
  • scopus:84858289524
ISSN
0928-4931
DOI
10.1016/j.msec.2012.01.021
language
English
LU publication?
no
id
a41e1cf0-ac52-4acb-82aa-e48541e07a2d
date added to LUP
2025-05-11 22:42:25
date last changed
2025-05-13 13:42:13
@article{a41e1cf0-ac52-4acb-82aa-e48541e07a2d,
  abstract     = {{<p>Biomaterials have played an important role in the treatment of disease and the improvement of health care. Synthetic and naturally occurring biodegradable and biocompatible polymers have been used as biomaterials. Polyhydroxyalkanoates (PHAs) are promising materials for biomedical applications because they are biodegradable, non-toxic and biocompatible. We will shortly summarize the modification reactions, which include functionalization and grafting reactions, to improve the mechanical, thermal and hydrophilic properties of PHAs. The use of the modified PHAs in numerous biomedical applications, such as sutures, cardiovascular patches, wound dressings, scaffolds in tissue engineering, tissue repair/regeneration devices, drug carriers will be discussed in this review.</p>}},
  author       = {{Hazer, Derya Burcu and Kiliçay, Ebru and Hazer, Baki}},
  issn         = {{0928-4931}},
  keywords     = {{Biocompatibility; Biomaterials; Medical applications; Microbial polyester; Poly(3-hydroxy alkanoate)}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{4}},
  pages        = {{637--647}},
  publisher    = {{Elsevier}},
  series       = {{Materials Science and Engineering C}},
  title        = {{Poly(3-hydroxyalkanoate)s : Diversification and biomedical applications: A state of the art review}},
  url          = {{http://dx.doi.org/10.1016/j.msec.2012.01.021}},
  doi          = {{10.1016/j.msec.2012.01.021}},
  volume       = {{32}},
  year         = {{2012}},
}