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Silent myelin-weighted magnetic resonance imaging

Wood, Tobias C ; Damestani, Nikou L ; Lawrence, Andrew J ; Ljungberg, Emil LU orcid ; Barker, Gareth J ; Solana, Ana Beatriz ; Wiesinger, Florian and Williams, Steven C R (2020) In Wellcome Open Research 5.
Abstract

Background: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquisition. We sought to address this by modifying a near silent MRI sequence to include ihMT contrast. Methods: A Magnetization Transfer preparation module was incorporated into a radial Zero Echo-Time sequence. Repeatability of the ihMT ratio and inverse ihMT ratio were assessed in a cohort of healthy subjects. We also investigated how head orientation affects ihMT across subjects, as a previous study in a single subject suggests this as a... (More)

Background: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquisition. We sought to address this by modifying a near silent MRI sequence to include ihMT contrast. Methods: A Magnetization Transfer preparation module was incorporated into a radial Zero Echo-Time sequence. Repeatability of the ihMT ratio and inverse ihMT ratio were assessed in a cohort of healthy subjects. We also investigated how head orientation affects ihMT across subjects, as a previous study in a single subject suggests this as a potential confound. Results: We demonstrated that ihMT ratios comparable to existing, acoustically loud, implementations could be obtained with the silent sequence. We observed a small but significant effect of head orientation on inverse ihMTR. Conclusions: Silent ihMT imaging is a comparable alternative to conventional, noisy, alternatives. For all future ihMT studies we recommend careful positioning of the subject within the scanner.

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author
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publishing date
type
Contribution to journal
publication status
published
subject
in
Wellcome Open Research
volume
5
article number
74
publisher
F1000 Research Ltd.
external identifiers
  • pmid:32832700
  • scopus:85089777795
ISSN
2398-502X
DOI
10.12688/wellcomeopenres.15845.2
language
English
LU publication?
no
additional info
Copyright: © 2020 Wood TC et al.
id
a45bd386-ab61-48bc-bf4c-4a0e23354e7f
date added to LUP
2023-04-21 10:37:47
date last changed
2024-06-01 01:18:54
@article{a45bd386-ab61-48bc-bf4c-4a0e23354e7f,
  abstract     = {{<p>Background: Inhomogeneous Magnetization Transfer (ihMT) is an emerging, uniquely myelin-specific magnetic resonance imaging (MRI) contrast. Current ihMT acquisitions utilise fast Gradient Echo sequences which are among the most acoustically noisy MRI sequences, reducing patient comfort during acquisition. We sought to address this by modifying a near silent MRI sequence to include ihMT contrast. Methods: A Magnetization Transfer preparation module was incorporated into a radial Zero Echo-Time sequence. Repeatability of the ihMT ratio and inverse ihMT ratio were assessed in a cohort of healthy subjects. We also investigated how head orientation affects ihMT across subjects, as a previous study in a single subject suggests this as a potential confound. Results: We demonstrated that ihMT ratios comparable to existing, acoustically loud, implementations could be obtained with the silent sequence. We observed a small but significant effect of head orientation on inverse ihMTR. Conclusions: Silent ihMT imaging is a comparable alternative to conventional, noisy, alternatives. For all future ihMT studies we recommend careful positioning of the subject within the scanner.</p>}},
  author       = {{Wood, Tobias C and Damestani, Nikou L and Lawrence, Andrew J and Ljungberg, Emil and Barker, Gareth J and Solana, Ana Beatriz and Wiesinger, Florian and Williams, Steven C R}},
  issn         = {{2398-502X}},
  language     = {{eng}},
  publisher    = {{F1000 Research Ltd.}},
  series       = {{Wellcome Open Research}},
  title        = {{Silent myelin-weighted magnetic resonance imaging}},
  url          = {{http://dx.doi.org/10.12688/wellcomeopenres.15845.2}},
  doi          = {{10.12688/wellcomeopenres.15845.2}},
  volume       = {{5}},
  year         = {{2020}},
}