Drug Repurposing in Oncology : Current Evidence and Future Direction
Zhang, Zhenzhan ; Ji, Jianguang LU
and Liu, Hao
LU
(2020)
In Current Medicinal Chemistry
28(11).
p.2175-2194
- Abstract
BACKGROUND: Drug repurposing, the application of known drugs and compounds with a non-oncology primary purpose, might be an attractive strategy to offer more effective treatment options to patients with cancer at a low cost and reduced time.
METHODS: This review described a total of 10 kinds of non-oncological drugs from more than 100 mechanical studies as well as evidence from population-based studies. The future direction of repurposed drug screening was discussed by using patient-derived tumor organoids.
RESULTS: Many old drugs showed previously unknown effects or off-target effects and can be intelligently applied for cancer chemoprevention and therapy. The identification of repurposed drugs needs to combine evidence... (More)
BACKGROUND: Drug repurposing, the application of known drugs and compounds with a non-oncology primary purpose, might be an attractive strategy to offer more effective treatment options to patients with cancer at a low cost and reduced time.
METHODS: This review described a total of 10 kinds of non-oncological drugs from more than 100 mechanical studies as well as evidence from population-based studies. The future direction of repurposed drug screening was discussed by using patient-derived tumor organoids.
RESULTS: Many old drugs showed previously unknown effects or off-target effects and can be intelligently applied for cancer chemoprevention and therapy. The identification of repurposed drugs needs to combine evidence from mechanical studies and population-based studies. Due to the heterogeneity of cancer, patient-derived tumor organoids can be used to screen the non-oncological drugs in vitro.
CONCLUSION: These identified old drugs could be repurposed in oncology and might be added as adjuvants and finally benefit patients with cancers.
(Less)
- author
- Zhang, Zhenzhan
; Ji, Jianguang
LU
and Liu, Hao
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Medicinal Chemistry
- volume
- 28
- issue
- 11
- pages
- 2175 - 2194
- publisher
- Bentham Science Publishers
- external identifiers
-
- pmid:33109032
- scopus:85104944304
- ISSN
- 0929-8673
- DOI
- 10.2174/0929867327999200820124111
- language
- English
- LU publication?
- yes
- id
- a45c7fda-0a23-4e14-b760-8ac63bd9ee5e
- date added to LUP
- 2020-11-12 09:22:08
- date last changed
- 2024-06-12 23:44:02
@article{a45c7fda-0a23-4e14-b760-8ac63bd9ee5e,
abstract = {{<p>BACKGROUND: Drug repurposing, the application of known drugs and compounds with a non-oncology primary purpose, might be an attractive strategy to offer more effective treatment options to patients with cancer at a low cost and reduced time.</p><p>METHODS: This review described a total of 10 kinds of non-oncological drugs from more than 100 mechanical studies as well as evidence from population-based studies. The future direction of repurposed drug screening was discussed by using patient-derived tumor organoids.</p><p>RESULTS: Many old drugs showed previously unknown effects or off-target effects and can be intelligently applied for cancer chemoprevention and therapy. The identification of repurposed drugs needs to combine evidence from mechanical studies and population-based studies. Due to the heterogeneity of cancer, patient-derived tumor organoids can be used to screen the non-oncological drugs in vitro.</p><p>CONCLUSION: These identified old drugs could be repurposed in oncology and might be added as adjuvants and finally benefit patients with cancers.</p>}},
author = {{Zhang, Zhenzhan and Ji, Jianguang and Liu, Hao}},
issn = {{0929-8673}},
language = {{eng}},
number = {{11}},
pages = {{2175--2194}},
publisher = {{Bentham Science Publishers}},
series = {{Current Medicinal Chemistry}},
title = {{Drug Repurposing in Oncology : Current Evidence and Future Direction}},
url = {{http://dx.doi.org/10.2174/0929867327999200820124111}},
doi = {{10.2174/0929867327999200820124111}},
volume = {{28}},
year = {{2020}},
}