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Finnish new variant of Chlamydia trachomatis escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019

Unemo, Magnus ; Hansen, Marit ; Hadad, Ronza ; Lindroth, Ylva LU ; Fredlund, Hans ; Puolakkainen, Mirja and Sundqvist, Martin (2019) In Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 24(26).
Abstract

We identified the first two cases of the Finnish new variant of Chlamydia trachomatis (F-nvCT) beyond Finland in two clinical urogenital specimens in Örebro County, Sweden. These Aptima Combo 2 assay-negative specimens were Aptima Chlamydia trachomatis (CT) assay positive and had the characteristic C1515T mutation in the 23S rRNA gene. From 22 March to 31 May 2019, 1.3% (2/158) of the CT-positive cases in Örebro County were missed because of the F-nvCT. International awareness, investigations and actions are essential.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chlamydia trachomatis, Diagnostics, Finland, NAAT, nvCT, Sweden
in
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
volume
24
issue
26
publisher
European Centre for Disease Prevention and Control (ECDC)
external identifiers
  • scopus:85069267549
  • pmid:31266590
ISSN
1560-7917
DOI
10.2807/1560-7917.ES.2019.24.26.1900370
language
English
LU publication?
yes
id
a46fb9dc-5211-4628-a2d5-f29ff88c2770
date added to LUP
2019-07-29 15:21:15
date last changed
2020-07-29 05:57:58
@article{a46fb9dc-5211-4628-a2d5-f29ff88c2770,
  abstract     = {<p>We identified the first two cases of the Finnish new variant of Chlamydia trachomatis (F-nvCT) beyond Finland in two clinical urogenital specimens in Örebro County, Sweden. These Aptima Combo 2 assay-negative specimens were Aptima Chlamydia trachomatis (CT) assay positive and had the characteristic C1515T mutation in the 23S rRNA gene. From 22 March to 31 May 2019, 1.3% (2/158) of the CT-positive cases in Örebro County were missed because of the F-nvCT. International awareness, investigations and actions are essential.</p>},
  author       = {Unemo, Magnus and Hansen, Marit and Hadad, Ronza and Lindroth, Ylva and Fredlund, Hans and Puolakkainen, Mirja and Sundqvist, Martin},
  issn         = {1560-7917},
  language     = {eng},
  month        = {06},
  number       = {26},
  publisher    = {European Centre for Disease Prevention and Control (ECDC)},
  series       = {Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin},
  title        = {Finnish new variant of Chlamydia trachomatis escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019},
  url          = {http://dx.doi.org/10.2807/1560-7917.ES.2019.24.26.1900370},
  doi          = {10.2807/1560-7917.ES.2019.24.26.1900370},
  volume       = {24},
  year         = {2019},
}