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Finnish new variant of Chlamydia trachomatis escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019

Unemo, Magnus ; Hansen, Marit ; Hadad, Ronza ; Lindroth, Ylva LU ; Fredlund, Hans ; Puolakkainen, Mirja and Sundqvist, Martin (2019) In Eurosurveillance 24(26).
Abstract

We identified the first two cases of the Finnish new variant of Chlamydia trachomatis (F-nvCT) beyond Finland in two clinical urogenital specimens in Örebro County, Sweden. These Aptima Combo 2 assay-negative specimens were Aptima Chlamydia trachomatis (CT) assay positive and had the characteristic C1515T mutation in the 23S rRNA gene. From 22 March to 31 May 2019, 1.3% (2/158) of the CT-positive cases in Örebro County were missed because of the F-nvCT. International awareness, investigations and actions are essential.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chlamydia trachomatis, Diagnostics, Finland, NAAT, nvCT, Sweden
in
Eurosurveillance
volume
24
issue
26
publisher
European Centre for Disease Prevention and Control (ECDC)
external identifiers
  • pmid:31266590
  • scopus:85069267549
ISSN
1560-7917
DOI
10.2807/1560-7917.ES.2019.24.26.1900370
language
English
LU publication?
yes
id
a46fb9dc-5211-4628-a2d5-f29ff88c2770
date added to LUP
2019-07-29 15:21:15
date last changed
2025-10-14 13:25:23
@article{a46fb9dc-5211-4628-a2d5-f29ff88c2770,
  abstract     = {{<p>We identified the first two cases of the Finnish new variant of Chlamydia trachomatis (F-nvCT) beyond Finland in two clinical urogenital specimens in Örebro County, Sweden. These Aptima Combo 2 assay-negative specimens were Aptima Chlamydia trachomatis (CT) assay positive and had the characteristic C1515T mutation in the 23S rRNA gene. From 22 March to 31 May 2019, 1.3% (2/158) of the CT-positive cases in Örebro County were missed because of the F-nvCT. International awareness, investigations and actions are essential.</p>}},
  author       = {{Unemo, Magnus and Hansen, Marit and Hadad, Ronza and Lindroth, Ylva and Fredlund, Hans and Puolakkainen, Mirja and Sundqvist, Martin}},
  issn         = {{1560-7917}},
  keywords     = {{Chlamydia trachomatis; Diagnostics; Finland; NAAT; nvCT; Sweden}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{26}},
  publisher    = {{European Centre for Disease Prevention and Control (ECDC)}},
  series       = {{Eurosurveillance}},
  title        = {{Finnish new variant of Chlamydia trachomatis escaping detection in the Aptima Combo 2 assay also present in Örebro County, Sweden, May 2019}},
  url          = {{http://dx.doi.org/10.2807/1560-7917.ES.2019.24.26.1900370}},
  doi          = {{10.2807/1560-7917.ES.2019.24.26.1900370}},
  volume       = {{24}},
  year         = {{2019}},
}