Long-term resolution of chronic macular edema after a single dose of intravitreal dexamethasone in familial retinal arterial macroaneurysm
AlZaid, Abdulrahman ; Magliyah, Moustafa ; Schatz, Patrik LU
and Al-Dhibi, Hassan
(2020)
In Ophthalmic Genetics
41(4).
p.394-396
- Abstract
Purpose: To report a favorable effect of intravitreal dexamethasone implantation in Familial Retinal Arterial Macroaneurysms (FRAM). Methods: Retrospective Case Report. Results: A 32-year-old male who presented with bilateral retinal macroaneurysms. Whole Exome Sequencing (WES) revealed a homozygous c.830–1 G > A mutation in Insulin Growth Factor Binding Protein 7 (IGFBP7) gene, confirming the diagnosis FRAM. The left eye was lost in the course of the disease, whereas the right eye developed a persistent macular edema due to multiple leaking retinal arterial macroaneurysms and responded poorly to intravitreal ranibizumab and only partially to intravitreal aflibercept. Intravitreal dexamethasone implantation in the right eye, on the... (More)
Purpose: To report a favorable effect of intravitreal dexamethasone implantation in Familial Retinal Arterial Macroaneurysms (FRAM). Methods: Retrospective Case Report. Results: A 32-year-old male who presented with bilateral retinal macroaneurysms. Whole Exome Sequencing (WES) revealed a homozygous c.830–1 G > A mutation in Insulin Growth Factor Binding Protein 7 (IGFBP7) gene, confirming the diagnosis FRAM. The left eye was lost in the course of the disease, whereas the right eye developed a persistent macular edema due to multiple leaking retinal arterial macroaneurysms and responded poorly to intravitreal ranibizumab and only partially to intravitreal aflibercept. Intravitreal dexamethasone implantation in the right eye, on the other hand, resulted in marked visual and structural improvement. Conclusion: Intravitreal dexamethasone injections have beneficial anatomical and visual outcomes in FRAM patients with persistent macular edema poorly responsive to intravitreal injections.
(Less)
- author
- AlZaid, Abdulrahman
; Magliyah, Moustafa
; Schatz, Patrik
LU
and Al-Dhibi, Hassan
- organization
- publishing date
- 2020-05-19
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CME, FRAM, IGFBP7, persistent macular edema, RAM
- in
- Ophthalmic Genetics
- volume
- 41
- issue
- 4
- pages
- 3 pages
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:85085359570
- pmid:32429784
- ISSN
- 1381-6810
- DOI
- 10.1080/13816810.2020.1766088
- language
- English
- LU publication?
- yes
- id
- a477e0fe-5666-4f49-aac7-535f9d3f0c88
- date added to LUP
- 2020-06-26 15:24:56
- date last changed
- 2024-04-03 10:06:28
@article{a477e0fe-5666-4f49-aac7-535f9d3f0c88,
abstract = {{<p>Purpose: To report a favorable effect of intravitreal dexamethasone implantation in Familial Retinal Arterial Macroaneurysms (FRAM). Methods: Retrospective Case Report. Results: A 32-year-old male who presented with bilateral retinal macroaneurysms. Whole Exome Sequencing (WES) revealed a homozygous c.830–1 G > A mutation in Insulin Growth Factor Binding Protein 7 (IGFBP7) gene, confirming the diagnosis FRAM. The left eye was lost in the course of the disease, whereas the right eye developed a persistent macular edema due to multiple leaking retinal arterial macroaneurysms and responded poorly to intravitreal ranibizumab and only partially to intravitreal aflibercept. Intravitreal dexamethasone implantation in the right eye, on the other hand, resulted in marked visual and structural improvement. Conclusion: Intravitreal dexamethasone injections have beneficial anatomical and visual outcomes in FRAM patients with persistent macular edema poorly responsive to intravitreal injections.</p>}},
author = {{AlZaid, Abdulrahman and Magliyah, Moustafa and Schatz, Patrik and Al-Dhibi, Hassan}},
issn = {{1381-6810}},
keywords = {{CME; FRAM; IGFBP7; persistent macular edema; RAM}},
language = {{eng}},
month = {{05}},
number = {{4}},
pages = {{394--396}},
publisher = {{Taylor & Francis}},
series = {{Ophthalmic Genetics}},
title = {{Long-term resolution of chronic macular edema after a single dose of intravitreal dexamethasone in familial retinal arterial macroaneurysm}},
url = {{http://dx.doi.org/10.1080/13816810.2020.1766088}},
doi = {{10.1080/13816810.2020.1766088}},
volume = {{41}},
year = {{2020}},
}