D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus.
(2005) In Diabetologia 48(12). p.2540-2543- Abstract
- Aims/hypothesis: The HLA class II DQB1*0602 allele confers strong dominant protection against type 1 diabetes but protection is not absolute. The aim of this study was to identify markers within the HLA region that differentiate DQB1*0602 haplotypes and show different associations with disease risk.
Methods: We defined alleles at eight microsatellite markers spanning the HLA region in a case-control cohort from Sweden.
Results: We found that allele 15 at marker D6S265 (109 kb centromeric of HLA-A) was over-represented among patients carrying DRB1*15, DQB1*0602. A detailed haplotype analysis showed that DRB1*15, DQB1*0602 haplotypes carrying D6S265*15 have a ten-fold higher odds ratio (OR) than those carrying other alleles... (More) - Aims/hypothesis: The HLA class II DQB1*0602 allele confers strong dominant protection against type 1 diabetes but protection is not absolute. The aim of this study was to identify markers within the HLA region that differentiate DQB1*0602 haplotypes and show different associations with disease risk.
Methods: We defined alleles at eight microsatellite markers spanning the HLA region in a case-control cohort from Sweden.
Results: We found that allele 15 at marker D6S265 (109 kb centromeric of HLA-A) was over-represented among patients carrying DRB1*15, DQB1*0602. A detailed haplotype analysis showed that DRB1*15, DQB1*0602 haplotypes carrying D6S265*15 have a ten-fold higher odds ratio (OR) than those carrying other alleles and thus confer reduced protection [OR D6S265*15=0.186 (95% CI 0.074, 0.472) vs OR D6S265*15−=0.017 (95% CI 0.005, 0.062), p<0.001].
Conclusions/interpretation: Our data support the existence of a locus that modifies the protective effect associated with DQB1*0602. Typing for allele D6S265*15 can identify a less protective DQB1*0602 haplotype, thereby allowing a more accurate prediction of type 1 diabetes risk.
Electronic Supplementary Material: Supplementary material is available for this article at http://dx.doi.org/10.1007/s00125-005-0011-8 (Less)
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https://lup.lub.lu.se/record/1133058
- author
- author collaboration
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- D6S265, DQB1*0602, HLA-DQ antigens, IDDM, Type 1 diabetes mellitus
- in
- Diabetologia
- volume
- 48
- issue
- 12
- pages
- 2540 - 2543
- publisher
- Springer
- external identifiers
-
- scopus:28444477379
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-005-0011-8
- language
- English
- LU publication?
- no
- id
- a486139d-1966-452f-88d8-8d3e6c9673f9 (old id 1133058)
- date added to LUP
- 2016-04-01 12:30:40
- date last changed
- 2022-02-18 23:27:33
@article{a486139d-1966-452f-88d8-8d3e6c9673f9, abstract = {{Aims/hypothesis: The HLA class II DQB1*0602 allele confers strong dominant protection against type 1 diabetes but protection is not absolute. The aim of this study was to identify markers within the HLA region that differentiate DQB1*0602 haplotypes and show different associations with disease risk.<br/><br> Methods: We defined alleles at eight microsatellite markers spanning the HLA region in a case-control cohort from Sweden.<br/><br> Results: We found that allele 15 at marker D6S265 (109 kb centromeric of HLA-A) was over-represented among patients carrying DRB1*15, DQB1*0602. A detailed haplotype analysis showed that DRB1*15, DQB1*0602 haplotypes carrying D6S265*15 have a ten-fold higher odds ratio (OR) than those carrying other alleles and thus confer reduced protection [OR D6S265*15=0.186 (95% CI 0.074, 0.472) vs OR D6S265*15−=0.017 (95% CI 0.005, 0.062), p<0.001].<br/><br> Conclusions/interpretation: Our data support the existence of a locus that modifies the protective effect associated with DQB1*0602. Typing for allele D6S265*15 can identify a less protective DQB1*0602 haplotype, thereby allowing a more accurate prediction of type 1 diabetes risk.<br/><br> Electronic Supplementary Material: Supplementary material is available for this article at http://dx.doi.org/10.1007/s00125-005-0011-8}}, author = {{Valdes, A M and Thomson, G and Graham, J and Zarghami, M and McNeney, B and Kockum, I and Smith, A and Lathrop, M and Steenkiste, A R and Dorman, J S and Noble, J A and Hansen, J A and Pugliese, A and Lernmark, Åke}}, issn = {{1432-0428}}, keywords = {{D6S265; DQB1*0602; HLA-DQ antigens; IDDM; Type 1 diabetes mellitus}}, language = {{eng}}, number = {{12}}, pages = {{2540--2543}}, publisher = {{Springer}}, series = {{Diabetologia}}, title = {{D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus.}}, url = {{http://dx.doi.org/10.1007/s00125-005-0011-8}}, doi = {{10.1007/s00125-005-0011-8}}, volume = {{48}}, year = {{2005}}, }