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Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men : The Sympathetic activity and Ambulatory Blood Pressure in Africans study

Jansen van Vuren, Esmé; Malan, Leoné; von Känel, Roland; Magnusson, Martin LU ; Lammertyn, Leandi and Malan, Nicolaas T. (2019) In Diabetes and Vascular Disease Research 16(3). p.236-243
Abstract

Objective: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort. Methods: Black and White teachers (N = 338, aged 20–63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Fasting blood samples were obtained for cardiac troponin T, N-terminal brain natriuretic peptide,... (More)

Objective: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort. Methods: Black and White teachers (N = 338, aged 20–63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Fasting blood samples were obtained for cardiac troponin T, N-terminal brain natriuretic peptide, glycated haemoglobin and the homeostatic model assessment-insulin resistance for insulin resistance. The Stroop colour-word conflict test was applied to assess executive cognitive function at baseline. Results: Over the 3-year period, Black men revealed constant high levels of cardiac troponin T (⩾4.2 ng/L), pre-diabetes (glycated haemoglobin > 5.7%) and insulin resistance (homeostatic model assessment-insulin resistance >3). %Δ Glycated haemoglobin was associated with %Δ insulin resistance (p < 0.001) and increases in %ΔN-terminal brain natriuretic peptide (p = 0.02) in Black men only. In the latter, baseline Stroop colour-word conflict test was inversely associated with %Δ cardiac troponin T (p = 0.001) and %Δ insulin resistance levels (p = 0.01). Conclusion: Progressive myocyte stretch and chronic myocyte injury, coupled with glucose dysregulation, may interfere with processes related to interference control in Black men.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiac troponin, cognition, hyperglycaemia, insulin resistance, N-terminal brain natriuretic peptide
in
Diabetes and Vascular Disease Research
volume
16
issue
3
pages
236 - 243
publisher
SAGE Publications Inc.
external identifiers
  • scopus:85058973696
ISSN
1479-1641
DOI
10.1177/1479164118816221
language
English
LU publication?
yes
id
a48de804-1284-4579-a47d-60f6fae7bee0
date added to LUP
2019-01-08 13:14:53
date last changed
2019-11-13 05:24:04
@article{a48de804-1284-4579-a47d-60f6fae7bee0,
  abstract     = {<p>Objective: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort. Methods: Black and White teachers (N = 338, aged 20–63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Fasting blood samples were obtained for cardiac troponin T, N-terminal brain natriuretic peptide, glycated haemoglobin and the homeostatic model assessment-insulin resistance for insulin resistance. The Stroop colour-word conflict test was applied to assess executive cognitive function at baseline. Results: Over the 3-year period, Black men revealed constant high levels of cardiac troponin T (⩾4.2 ng/L), pre-diabetes (glycated haemoglobin &gt; 5.7%) and insulin resistance (homeostatic model assessment-insulin resistance &gt;3). %Δ Glycated haemoglobin was associated with %Δ insulin resistance (p &lt; 0.001) and increases in %ΔN-terminal brain natriuretic peptide (p = 0.02) in Black men only. In the latter, baseline Stroop colour-word conflict test was inversely associated with %Δ cardiac troponin T (p = 0.001) and %Δ insulin resistance levels (p = 0.01). Conclusion: Progressive myocyte stretch and chronic myocyte injury, coupled with glucose dysregulation, may interfere with processes related to interference control in Black men.</p>},
  author       = {Jansen van Vuren, Esmé and Malan, Leoné and von Känel, Roland and Magnusson, Martin and Lammertyn, Leandi and Malan, Nicolaas T.},
  issn         = {1479-1641},
  keyword      = {cardiac troponin,cognition,hyperglycaemia,insulin resistance,N-terminal brain natriuretic peptide},
  language     = {eng},
  number       = {3},
  pages        = {236--243},
  publisher    = {SAGE Publications Inc.},
  series       = {Diabetes and Vascular Disease Research},
  title        = {Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men : The Sympathetic activity and Ambulatory Blood Pressure in Africans study},
  url          = {http://dx.doi.org/10.1177/1479164118816221},
  volume       = {16},
  year         = {2019},
}