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Complexation between antimicrobial peptides and polyelectrolytes

Borro, Bruno C. and Malmsten, Martin LU (2019) In Advances in Colloid and Interface Science 270. p.251-260
Abstract

As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is challenging, there is an emerging awareness that successful development of AMP therapeutics can be facilitated by careful design of AMPs delivery systems. In the present overview, we discuss polyelectrolyte complexation as a strategy to deliver AMPs. In doing so, key factors for AMP-polyelectrolyte complexation are illustrated for... (More)

As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is challenging, there is an emerging awareness that successful development of AMP therapeutics can be facilitated by careful design of AMPs delivery systems. In the present overview, we discuss polyelectrolyte complexation as a strategy to deliver AMPs. In doing so, key factors for AMP-polyelectrolyte complexation are illustrated for AMP-polyelectrolyte nanoparticle formation, as well as for AMP incorporation in polyelectrolyte microgels and multilayer structures, and consequences of these for functional performance exemplified.

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type
Contribution to journal
publication status
published
subject
keywords
Antimicrobial peptide, Complex, Microgel, Multilayer, Polyelectrolyte
in
Advances in Colloid and Interface Science
volume
270
pages
10 pages
publisher
Elsevier
external identifiers
  • scopus:85068529762
  • pmid:31301601
ISSN
0001-8686
DOI
10.1016/j.cis.2019.07.001
language
English
LU publication?
yes
id
a4d0d391-0025-4f0a-8e8c-cdb052737f05
date added to LUP
2019-07-16 10:39:49
date last changed
2024-01-01 16:10:47
@article{a4d0d391-0025-4f0a-8e8c-cdb052737f05,
  abstract     = {{<p>As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is challenging, there is an emerging awareness that successful development of AMP therapeutics can be facilitated by careful design of AMPs delivery systems. In the present overview, we discuss polyelectrolyte complexation as a strategy to deliver AMPs. In doing so, key factors for AMP-polyelectrolyte complexation are illustrated for AMP-polyelectrolyte nanoparticle formation, as well as for AMP incorporation in polyelectrolyte microgels and multilayer structures, and consequences of these for functional performance exemplified.</p>}},
  author       = {{Borro, Bruno C. and Malmsten, Martin}},
  issn         = {{0001-8686}},
  keywords     = {{Antimicrobial peptide; Complex; Microgel; Multilayer; Polyelectrolyte}},
  language     = {{eng}},
  pages        = {{251--260}},
  publisher    = {{Elsevier}},
  series       = {{Advances in Colloid and Interface Science}},
  title        = {{Complexation between antimicrobial peptides and polyelectrolytes}},
  url          = {{http://dx.doi.org/10.1016/j.cis.2019.07.001}},
  doi          = {{10.1016/j.cis.2019.07.001}},
  volume       = {{270}},
  year         = {{2019}},
}