Complexation between antimicrobial peptides and polyelectrolytes
(2019) In Advances in Colloid and Interface Science 270. p.251-260- Abstract
As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is challenging, there is an emerging awareness that successful development of AMP therapeutics can be facilitated by careful design of AMPs delivery systems. In the present overview, we discuss polyelectrolyte complexation as a strategy to deliver AMPs. In doing so, key factors for AMP-polyelectrolyte complexation are illustrated for... (More)
As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is challenging, there is an emerging awareness that successful development of AMP therapeutics can be facilitated by careful design of AMPs delivery systems. In the present overview, we discuss polyelectrolyte complexation as a strategy to deliver AMPs. In doing so, key factors for AMP-polyelectrolyte complexation are illustrated for AMP-polyelectrolyte nanoparticle formation, as well as for AMP incorporation in polyelectrolyte microgels and multilayer structures, and consequences of these for functional performance exemplified.
(Less)
- author
- Borro, Bruno C. and Malmsten, Martin LU
- organization
- publishing date
- 2019-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Antimicrobial peptide, Complex, Microgel, Multilayer, Polyelectrolyte
- in
- Advances in Colloid and Interface Science
- volume
- 270
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:31301601
- scopus:85068529762
- ISSN
- 0001-8686
- DOI
- 10.1016/j.cis.2019.07.001
- language
- English
- LU publication?
- yes
- id
- a4d0d391-0025-4f0a-8e8c-cdb052737f05
- date added to LUP
- 2019-07-16 10:39:49
- date last changed
- 2023-10-07 14:03:53
@article{a4d0d391-0025-4f0a-8e8c-cdb052737f05,
abstract = {{<p>As a result of increasing bacterial resistance against antibiotics, we are facing an emerging health crisis, in which ‘simple’ infections may no longer be treatable. One class of molecules attracting interest in this context is antimicrobial peptides (AMPs), and considerable research efforts have been directed to identifying selective and potent AMPs. In addition, since in vivo delivery of AMPs is challenging, there is an emerging awareness that successful development of AMP therapeutics can be facilitated by careful design of AMPs delivery systems. In the present overview, we discuss polyelectrolyte complexation as a strategy to deliver AMPs. In doing so, key factors for AMP-polyelectrolyte complexation are illustrated for AMP-polyelectrolyte nanoparticle formation, as well as for AMP incorporation in polyelectrolyte microgels and multilayer structures, and consequences of these for functional performance exemplified.</p>}},
author = {{Borro, Bruno C. and Malmsten, Martin}},
issn = {{0001-8686}},
keywords = {{Antimicrobial peptide; Complex; Microgel; Multilayer; Polyelectrolyte}},
language = {{eng}},
pages = {{251--260}},
publisher = {{Elsevier}},
series = {{Advances in Colloid and Interface Science}},
title = {{Complexation between antimicrobial peptides and polyelectrolytes}},
url = {{http://dx.doi.org/10.1016/j.cis.2019.07.001}},
doi = {{10.1016/j.cis.2019.07.001}},
volume = {{270}},
year = {{2019}},
}