A genome-wide association study of social trust in 33,882 Danish blood donors
(2024) In Scientific Reports 14(1).- Abstract
- Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a... (More)
- Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/a4e45a80-a268-40af-a607-6f26452a8db2
- author
- Sequeros, C.B. ; Kalamajski, S. LU ; Giordano, G.N. LU and Pedersen, O.B.V.
- author collaboration
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Blood Donors, Denmark, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Phenotype, Polymorphism, Single Nucleotide, Trust, blood donor, genetic predisposition, genome-wide association study, human, meta analysis, phenotype, single nucleotide polymorphism, trust
- in
- Scientific Reports
- volume
- 14
- issue
- 1
- article number
- 1402
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85182480285
- pmid:38228779
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-024-51636-0
- language
- English
- LU publication?
- yes
- id
- a4e45a80-a268-40af-a607-6f26452a8db2
- date added to LUP
- 2024-03-11 15:03:31
- date last changed
- 2024-03-12 03:00:10
@article{a4e45a80-a268-40af-a607-6f26452a8db2,
abstract = {{Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.}},
author = {{Sequeros, C.B. and Kalamajski, S. and Giordano, G.N. and Pedersen, O.B.V.}},
issn = {{2045-2322}},
keywords = {{Blood Donors; Denmark; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Phenotype; Polymorphism, Single Nucleotide; Trust; blood donor; genetic predisposition; genome-wide association study; human; meta analysis; phenotype; single nucleotide polymorphism; trust}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{A genome-wide association study of social trust in 33,882 Danish blood donors}},
url = {{http://dx.doi.org/10.1038/s41598-024-51636-0}},
doi = {{10.1038/s41598-024-51636-0}},
volume = {{14}},
year = {{2024}},
}