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Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study

Johnsen, M. B. ; Magnusson, K. LU ; Børte, S. ; Gabrielsen, M. E. ; Winsvold, B. S. ; Skogholt, A. H. ; Thomas, L. ; Storheim, K. ; Hveem, K. and Zwart, J. A. (2020) In Osteoarthritis and Cartilage 28(7). p.932-940
Abstract

Objective: To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design: We included 17,153 men and 18,682 women from a population-based cohort, aged 35–70 years at baseline (1995–1997). Incident hand OA were obtained from diagnostic codes in the Norwegian National Patient Register (1995–2018). We studied whether a range of self-reported and clinically measured predictors could predict hand OA, using the Area Under the receiver-operating Curve (AUC) from logistic regression. External validation of an existing prediction model for male hand OA was tested on discrimination in a sample of men. Bootstrapping was used to avoid... (More)

Objective: To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design: We included 17,153 men and 18,682 women from a population-based cohort, aged 35–70 years at baseline (1995–1997). Incident hand OA were obtained from diagnostic codes in the Norwegian National Patient Register (1995–2018). We studied whether a range of self-reported and clinically measured predictors could predict hand OA, using the Area Under the receiver-operating Curve (AUC) from logistic regression. External validation of an existing prediction model for male hand OA was tested on discrimination in a sample of men. Bootstrapping was used to avoid overfitting. Results: The model for men showed modest discriminatory ability (AUC = 0.67, 95% CI 0.62–0.71). Adding a genetic risk score did not improve prediction. Similar discrimination was observed in the model for women (AUC = 0.62, 95% CI 0.59–0.64). Prediction was not improved by adding a genetic risk score or hormonal and reproductive factors. Applying external validation, similar results were observed among men in HUNT (The Nord-Trøndelag Health Study) as in the developmental sample (AUC = 0.62, 95% CI 0.57–0.65). Conclusion: We developed prediction models for incident hand OA in men and women. For women, the model included body mass index (BMI), heavy physical work, high physical activity and perceived poor health. The model showed moderate discrimination. For men, we have shown that a prediction model including BMI, education and information on sleep can predict incident hand OA in several populations with moderate discriminative ability.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Discrimination, Hand, Osteoarthritis, Prediction, Risk
in
Osteoarthritis and Cartilage
volume
28
issue
7
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:85084856749
  • pmid:32360252
ISSN
1063-4584
DOI
10.1016/j.joca.2020.04.005
language
English
LU publication?
yes
id
a4e81a9d-3751-451f-85f0-abcd540c300c
date added to LUP
2020-06-16 14:15:51
date last changed
2024-05-01 11:36:53
@article{a4e81a9d-3751-451f-85f0-abcd540c300c,
  abstract     = {{<p>Objective: To develop and externally validate prediction models for incident hand osteoarthritis (OA) in a large population-based cohort of middle aged and older men and women. Design: We included 17,153 men and 18,682 women from a population-based cohort, aged 35–70 years at baseline (1995–1997). Incident hand OA were obtained from diagnostic codes in the Norwegian National Patient Register (1995–2018). We studied whether a range of self-reported and clinically measured predictors could predict hand OA, using the Area Under the receiver-operating Curve (AUC) from logistic regression. External validation of an existing prediction model for male hand OA was tested on discrimination in a sample of men. Bootstrapping was used to avoid overfitting. Results: The model for men showed modest discriminatory ability (AUC = 0.67, 95% CI 0.62–0.71). Adding a genetic risk score did not improve prediction. Similar discrimination was observed in the model for women (AUC = 0.62, 95% CI 0.59–0.64). Prediction was not improved by adding a genetic risk score or hormonal and reproductive factors. Applying external validation, similar results were observed among men in HUNT (The Nord-Trøndelag Health Study) as in the developmental sample (AUC = 0.62, 95% CI 0.57–0.65). Conclusion: We developed prediction models for incident hand OA in men and women. For women, the model included body mass index (BMI), heavy physical work, high physical activity and perceived poor health. The model showed moderate discrimination. For men, we have shown that a prediction model including BMI, education and information on sleep can predict incident hand OA in several populations with moderate discriminative ability.</p>}},
  author       = {{Johnsen, M. B. and Magnusson, K. and Børte, S. and Gabrielsen, M. E. and Winsvold, B. S. and Skogholt, A. H. and Thomas, L. and Storheim, K. and Hveem, K. and Zwart, J. A.}},
  issn         = {{1063-4584}},
  keywords     = {{Discrimination; Hand; Osteoarthritis; Prediction; Risk}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{932--940}},
  publisher    = {{Elsevier}},
  series       = {{Osteoarthritis and Cartilage}},
  title        = {{Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study}},
  url          = {{http://dx.doi.org/10.1016/j.joca.2020.04.005}},
  doi          = {{10.1016/j.joca.2020.04.005}},
  volume       = {{28}},
  year         = {{2020}},
}