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Association between NAFLD and risk of prevalent chronic kidney disease : Why there is a difference between east and west?

Zhang, Min ; Lin, Su ; Wang, Ming Fang ; Huang, Jiao Feng ; Liu, Shi Ying ; Wu, Su Mei ; Zhang, Hao Yang LU orcid ; Wu, Zi Mu ; Liu, Wen Yue and Zhang, Dong Chu , et al. (2020) In BMC Gastroenterology 20. p.1-7
Abstract

Backgrounds: There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from the US and China. Methods: Two health examination datasets from China and the US were used. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 or and/or abnormal albuminuria and/or overt proteinuria. Binary logistic regression was used to examine the association between NAFLD and CKD. Results: A total of 60,965 participants were analyzed, including 11,844 from the US and... (More)

Backgrounds: There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from the US and China. Methods: Two health examination datasets from China and the US were used. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2 or and/or abnormal albuminuria and/or overt proteinuria. Binary logistic regression was used to examine the association between NAFLD and CKD. Results: A total of 60,965 participants were analyzed, including 11,844 from the US and 51,229 from China. The prevalence of NAFLD was 27.12% in the Chinese population and 36.08% in the US population (p < 0.001). The proportions of CKD and late stage CKD (stages 3-5) were higher in the US population than the Chinese one. NAFLD was independently associated with an increased risk of CKD in Chinese population, whereas in the US population, the NAFLD was not an independent risk factor of CKD. In subgroup analyses which excluded late stages CKD (stages 3-5), the risks of mild renal function decline became consistent: NAFLD was associated with early stages of CKD but not the late stages of CKD in both populations. Conclusion: NAFLD increased the risk of early stages of CKD in both Chinese and the US population. The conflicting results reported by previous studies might result from the different proportion of late stages of CKD.

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publishing date
type
Contribution to journal
publication status
published
keywords
Chronic renal disease, Non-alcoholic fatty liver disease
in
BMC Gastroenterology
volume
20
article number
139
pages
1 - 7
publisher
BioMed Central (BMC)
external identifiers
  • pmid:32375660
  • scopus:85084409227
ISSN
1471-230X
DOI
10.1186/s12876-020-01278-z
language
English
LU publication?
no
additional info
Publisher Copyright: © 2020 The Author(s).
id
a4f8ae69-eb30-44f8-8b4c-682d8b225c0f
date added to LUP
2024-02-05 15:47:53
date last changed
2024-04-22 00:03:00
@article{a4f8ae69-eb30-44f8-8b4c-682d8b225c0f,
  abstract     = {{<p>Backgrounds: There is a discrepancy between west and east on the relationship between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD). This study aimed to find out the possible reason for this and to clarify the association between NAFLD and CKD by analyzing two population-based datasets from the US and China. Methods: Two health examination datasets from China and the US were used. CKD was defined as an estimated glomerular filtration rate (eGFR) &lt; 60 ml/min/1.73m<sup>2</sup> or and/or abnormal albuminuria and/or overt proteinuria. Binary logistic regression was used to examine the association between NAFLD and CKD. Results: A total of 60,965 participants were analyzed, including 11,844 from the US and 51,229 from China. The prevalence of NAFLD was 27.12% in the Chinese population and 36.08% in the US population (p &lt; 0.001). The proportions of CKD and late stage CKD (stages 3-5) were higher in the US population than the Chinese one. NAFLD was independently associated with an increased risk of CKD in Chinese population, whereas in the US population, the NAFLD was not an independent risk factor of CKD. In subgroup analyses which excluded late stages CKD (stages 3-5), the risks of mild renal function decline became consistent: NAFLD was associated with early stages of CKD but not the late stages of CKD in both populations. Conclusion: NAFLD increased the risk of early stages of CKD in both Chinese and the US population. The conflicting results reported by previous studies might result from the different proportion of late stages of CKD.</p>}},
  author       = {{Zhang, Min and Lin, Su and Wang, Ming Fang and Huang, Jiao Feng and Liu, Shi Ying and Wu, Su Mei and Zhang, Hao Yang and Wu, Zi Mu and Liu, Wen Yue and Zhang, Dong Chu and Hao, Chuan Ming and Zhu, Yue Yong and Zheng, Ming Hua and Wang, Xiao Zhong}},
  issn         = {{1471-230X}},
  keywords     = {{Chronic renal disease; Non-alcoholic fatty liver disease}},
  language     = {{eng}},
  month        = {{05}},
  pages        = {{1--7}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Gastroenterology}},
  title        = {{Association between NAFLD and risk of prevalent chronic kidney disease : Why there is a difference between east and west?}},
  url          = {{http://dx.doi.org/10.1186/s12876-020-01278-z}},
  doi          = {{10.1186/s12876-020-01278-z}},
  volume       = {{20}},
  year         = {{2020}},
}