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Does inflammation have a role in migraine?

Edvinsson, Lars LU ; Haanes, Kristian Agmund and Warfvinge, Karin LU (2019) In Nature Reviews Neurology
Abstract

Migraine is a prevalent disorder, affecting 15.1% of the world’s population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develop chronic migraine. The mechanisms underlying this chronicity are unresolved but are hypothesized to involve a degree of inflammation. In this article, we review the relevant literature related to inflammation and migraine, from the initiation of attacks to chronification. We propose that the increase in migraine frequency leading to chronic migraine involves neurogenic neuroinflammation, possibly entailing increased expression of cytokines via activation of protein kinases in... (More)

Migraine is a prevalent disorder, affecting 15.1% of the world’s population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develop chronic migraine. The mechanisms underlying this chronicity are unresolved but are hypothesized to involve a degree of inflammation. In this article, we review the relevant literature related to inflammation and migraine, from the initiation of attacks to chronification. We propose that the increase in migraine frequency leading to chronic migraine involves neurogenic neuroinflammation, possibly entailing increased expression of cytokines via activation of protein kinases in neurons and glial cells of the trigeminovascular system. We present evidence from preclinical research that supports this view and discuss the implications for migraine therapy.

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author
organization
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type
Contribution to journal
publication status
published
subject
in
Nature Reviews Neurology
publisher
Nature Publishing Group
external identifiers
  • scopus:85068585771
ISSN
1759-4758
DOI
10.1038/s41582-019-0216-y
language
English
LU publication?
yes
id
a4fcceaa-c41f-43f5-aed5-3277e92db426
date added to LUP
2019-07-18 08:40:12
date last changed
2019-10-08 03:56:24
@misc{a4fcceaa-c41f-43f5-aed5-3277e92db426,
  abstract     = {<p>Migraine is a prevalent disorder, affecting 15.1% of the world’s population. In most cases, the migraine attacks are sporadic; however, some individuals experience a gradual increase in attack frequency over time, and up to 2% of the general population develop chronic migraine. The mechanisms underlying this chronicity are unresolved but are hypothesized to involve a degree of inflammation. In this article, we review the relevant literature related to inflammation and migraine, from the initiation of attacks to chronification. We propose that the increase in migraine frequency leading to chronic migraine involves neurogenic neuroinflammation, possibly entailing increased expression of cytokines via activation of protein kinases in neurons and glial cells of the trigeminovascular system. We present evidence from preclinical research that supports this view and discuss the implications for migraine therapy.</p>},
  author       = {Edvinsson, Lars and Haanes, Kristian Agmund and Warfvinge, Karin},
  issn         = {1759-4758},
  language     = {eng},
  month        = {07},
  publisher    = {Nature Publishing Group},
  series       = {Nature Reviews Neurology},
  title        = {Does inflammation have a role in migraine?},
  url          = {http://dx.doi.org/10.1038/s41582-019-0216-y},
  year         = {2019},
}