Effect of vacuum-assisted closure on blood flow in the peristernal thoracic wall after internal mammary artery harvesting.
Petzina, Rainer LU ; Gustafsson, Lotta LU
; Mokhtari, Arash
LU
; Ingemansson, Richard
LU
and Malmsjö, Malin
LU
(2006)
In European Journal of Cardio-Thoracic Surgery
30(1).
p.85-89
- Abstract
- Objective: Vacuum-assisted closure (VAC) is a recently introduced method for the treatment of poststernotomy mediastinitis. The aim was to examine the effects of VAC negative pressure on peristernal soft tissue, blood flow after internal mammary artery harvesting. Methods: Microvascular blood flow was measured using laser Doppler velocimetry in a porcine sternotomy wound model. The effect of VAC negative pressure on blood flow to the wound edge was investigated on the right side, where the internal mammary artery was intact, and on the left side, where the internal mammary artery had been removed. Results: Before removal of the left internal mammary artery, the blood flow was similar in the right and left peristernal wound edges, 2.5 cm... (More)
- Objective: Vacuum-assisted closure (VAC) is a recently introduced method for the treatment of poststernotomy mediastinitis. The aim was to examine the effects of VAC negative pressure on peristernal soft tissue, blood flow after internal mammary artery harvesting. Methods: Microvascular blood flow was measured using laser Doppler velocimetry in a porcine sternotomy wound model. The effect of VAC negative pressure on blood flow to the wound edge was investigated on the right side, where the internal mammary artery was intact, and on the left side, where the internal mammary artery had been removed. Results: Before removal of the left internal mammary artery, the blood flow was similar in the right and left peristernal wound edges, 2.5 cm from the edge (27 +/- 4 perfusion units (PU) on the right side and 32 +/- 3 PU on the left side, in muscle tissue). When the left internal mammary artery was surgically removed, the blood flow on the left side decreased (19 3 PU, in muscle tissue), while the skin blood flow was not affected. VAC negative pressure induced an immediate increase in wound edge blood flow both on the right side (43 +/- 9 PU, in muscle tissue at -75 mmHg), where the internal mammary artery was intact, and on the left side, where the internal mammary artery had been removed (49 11 PU, in muscle tissue at -75 mmHg). The increase in blood flow was similar on both sides at -75 mmHg and at -125 mmHg. Conclusions: The peristernal wound edge microvascular blood flow is decreased when the left internal mammary artery is removed. VAC therapy stimulates blood flow in the peristernal thoracic wall after internal mammary artery harvesting. (c) 2006 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/156534
- author
- Petzina, Rainer
LU
; Gustafsson, Lotta
LU
; Mokhtari, Arash
LU
; Ingemansson, Richard
LU
and Malmsjö, Malin
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- animal model, experimental surgery, tone and reactivity, wound healing, mediastinal infection, vascular
- in
- European Journal of Cardio-Thoracic Surgery
- volume
- 30
- issue
- 1
- pages
- 85 - 89
- publisher
- Oxford University Press
- external identifiers
-
- pmid:16730446
- wos:000238932900020
- scopus:33744939501
- ISSN
- 1010-7940
- DOI
- 10.1016/j.ejcts.2006.04.009
- language
- English
- LU publication?
- yes
- id
- a5046498-039a-419b-bd83-f4231b40c58a (old id 156534)
- alternative location
- http://ejcts.ctsnetjournals.org/cgi/content/full/30/1/85
- date added to LUP
- 2016-04-01 11:49:29
- date last changed
- 2024-02-06 10:31:11
@article{a5046498-039a-419b-bd83-f4231b40c58a,
abstract = {{Objective: Vacuum-assisted closure (VAC) is a recently introduced method for the treatment of poststernotomy mediastinitis. The aim was to examine the effects of VAC negative pressure on peristernal soft tissue, blood flow after internal mammary artery harvesting. Methods: Microvascular blood flow was measured using laser Doppler velocimetry in a porcine sternotomy wound model. The effect of VAC negative pressure on blood flow to the wound edge was investigated on the right side, where the internal mammary artery was intact, and on the left side, where the internal mammary artery had been removed. Results: Before removal of the left internal mammary artery, the blood flow was similar in the right and left peristernal wound edges, 2.5 cm from the edge (27 +/- 4 perfusion units (PU) on the right side and 32 +/- 3 PU on the left side, in muscle tissue). When the left internal mammary artery was surgically removed, the blood flow on the left side decreased (19 3 PU, in muscle tissue), while the skin blood flow was not affected. VAC negative pressure induced an immediate increase in wound edge blood flow both on the right side (43 +/- 9 PU, in muscle tissue at -75 mmHg), where the internal mammary artery was intact, and on the left side, where the internal mammary artery had been removed (49 11 PU, in muscle tissue at -75 mmHg). The increase in blood flow was similar on both sides at -75 mmHg and at -125 mmHg. Conclusions: The peristernal wound edge microvascular blood flow is decreased when the left internal mammary artery is removed. VAC therapy stimulates blood flow in the peristernal thoracic wall after internal mammary artery harvesting. (c) 2006 Elsevier B.V. All rights reserved.}},
author = {{Petzina, Rainer and Gustafsson, Lotta and Mokhtari, Arash and Ingemansson, Richard and Malmsjö, Malin}},
issn = {{1010-7940}},
keywords = {{animal model; experimental surgery; tone and reactivity; wound healing; mediastinal infection; vascular}},
language = {{eng}},
number = {{1}},
pages = {{85--89}},
publisher = {{Oxford University Press}},
series = {{European Journal of Cardio-Thoracic Surgery}},
title = {{Effect of vacuum-assisted closure on blood flow in the peristernal thoracic wall after internal mammary artery harvesting.}},
url = {{http://dx.doi.org/10.1016/j.ejcts.2006.04.009}},
doi = {{10.1016/j.ejcts.2006.04.009}},
volume = {{30}},
year = {{2006}},
}