Age-related macular degeneration is associated with increased proportion of CD56(+) T cells in peripheral blood
(2013) In Ophthalmology 120(11). p.6-2310- Abstract
PURPOSE: To examine the association between age-related changes in the T-cell compartment and prevalence of age-related macular degeneration (AMD).
DESIGN: Case-control study.
PARTICIPANTS: A total of 117 AMD cases and 106 controls were included prospectively.
METHODS: Fresh-drawn peripheral blood samples were processed for flow cytometric analysis of T-cell populations. Plasma samples were analyzed for anti-cytomegalovirus (CMV) immunoglobulin (Ig)G and complement factor H (CFH) Y402H genotype. The diagnosis of AMD was made according to the Clinical Age-Related Maculopathy Staging System.
MAIN OUTCOME MEASURES: Association between frequency of aged T cells and prevalence of AMD.
RESULTS: The prevalence of... (More)
PURPOSE: To examine the association between age-related changes in the T-cell compartment and prevalence of age-related macular degeneration (AMD).
DESIGN: Case-control study.
PARTICIPANTS: A total of 117 AMD cases and 106 controls were included prospectively.
METHODS: Fresh-drawn peripheral blood samples were processed for flow cytometric analysis of T-cell populations. Plasma samples were analyzed for anti-cytomegalovirus (CMV) immunoglobulin (Ig)G and complement factor H (CFH) Y402H genotype. The diagnosis of AMD was made according to the Clinical Age-Related Maculopathy Staging System.
MAIN OUTCOME MEASURES: Association between frequency of aged T cells and prevalence of AMD.
RESULTS: The prevalence of AMD was associated with distinct age-related changes in the T-cell compartment. Specifically, the patients with AMD had an increased frequency of CD28(-) T cells that expressed the CD56 surface marker (patients, 34.9% vs. aged controls, 25.8%; P = 0.002). Participants in the highest tertile of CD56(+) CD28(-) T cells had an odds ratio (OR) for the presence of AMD of 3.2 (95% confidence interval [CI], 1.2-8.8) after adjustment for CFH genotype, anti-CMV IgG positivity, age, sex, and smoking history. The adjusted OR of the presence of AMD for persons having at least 1 CFH H402 risk allele increased from 3.5 (95% CI, 1.5-8.1) to 13.3 (95% CI, 3.3-53.6) for persons with at least 1 CFH H402 risk allele and above the median level of CD56(+) CD28(-) T cells.
CONCLUSIONS: We found increased levels of circulating aged CD56(+) CD28(-) T cells in patients with AMD. Although this supports the notion of AMD as a systemic disease, it also suggests that the adaptive immune system is implicated in its pathogenesis.
(Less)
- author
- Faber, Carsten ; Singh, Amardeep LU ; Krüger Falk, Mads ; Juel, Helene Bæk ; Sørensen, Torben Lykke and Nissen, Mogens Holst
- publishing date
- 2013-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adaptive Immunity, Adult, Aged, Aged, 80 and over, Antibodies, Viral/blood, CD56 Antigen/immunology, Case-Control Studies, Complement Factor H/genetics, Cytomegalovirus/immunology, Enzyme-Linked Immunosorbent Assay, Female, Flow Cytometry, Fluorescein Angiography, Genotype, Humans, Macular Degeneration/blood, Male, Middle Aged, Polymorphism, Single Nucleotide, Prospective Studies, T-Lymphocytes/immunology, Tomography, Optical Coherence
- in
- Ophthalmology
- volume
- 120
- issue
- 11
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:23747161
- scopus:84887174355
- ISSN
- 1549-4713
- DOI
- 10.1016/j.ophtha.2013.04.014
- language
- English
- LU publication?
- no
- additional info
- Copyright © 2013 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
- id
- a51ecb5a-098f-4035-8125-e1a343d1963e
- date added to LUP
- 2019-05-21 10:55:30
- date last changed
- 2024-06-12 15:09:33
@article{a51ecb5a-098f-4035-8125-e1a343d1963e,
abstract = {{<p>PURPOSE: To examine the association between age-related changes in the T-cell compartment and prevalence of age-related macular degeneration (AMD).</p><p>DESIGN: Case-control study.</p><p>PARTICIPANTS: A total of 117 AMD cases and 106 controls were included prospectively.</p><p>METHODS: Fresh-drawn peripheral blood samples were processed for flow cytometric analysis of T-cell populations. Plasma samples were analyzed for anti-cytomegalovirus (CMV) immunoglobulin (Ig)G and complement factor H (CFH) Y402H genotype. The diagnosis of AMD was made according to the Clinical Age-Related Maculopathy Staging System.</p><p>MAIN OUTCOME MEASURES: Association between frequency of aged T cells and prevalence of AMD.</p><p>RESULTS: The prevalence of AMD was associated with distinct age-related changes in the T-cell compartment. Specifically, the patients with AMD had an increased frequency of CD28(-) T cells that expressed the CD56 surface marker (patients, 34.9% vs. aged controls, 25.8%; P = 0.002). Participants in the highest tertile of CD56(+) CD28(-) T cells had an odds ratio (OR) for the presence of AMD of 3.2 (95% confidence interval [CI], 1.2-8.8) after adjustment for CFH genotype, anti-CMV IgG positivity, age, sex, and smoking history. The adjusted OR of the presence of AMD for persons having at least 1 CFH H402 risk allele increased from 3.5 (95% CI, 1.5-8.1) to 13.3 (95% CI, 3.3-53.6) for persons with at least 1 CFH H402 risk allele and above the median level of CD56(+) CD28(-) T cells.</p><p>CONCLUSIONS: We found increased levels of circulating aged CD56(+) CD28(-) T cells in patients with AMD. Although this supports the notion of AMD as a systemic disease, it also suggests that the adaptive immune system is implicated in its pathogenesis.</p>}},
author = {{Faber, Carsten and Singh, Amardeep and Krüger Falk, Mads and Juel, Helene Bæk and Sørensen, Torben Lykke and Nissen, Mogens Holst}},
issn = {{1549-4713}},
keywords = {{Adaptive Immunity; Adult; Aged; Aged, 80 and over; Antibodies, Viral/blood; CD56 Antigen/immunology; Case-Control Studies; Complement Factor H/genetics; Cytomegalovirus/immunology; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Fluorescein Angiography; Genotype; Humans; Macular Degeneration/blood; Male; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; T-Lymphocytes/immunology; Tomography, Optical Coherence}},
language = {{eng}},
number = {{11}},
pages = {{6--2310}},
publisher = {{Elsevier}},
series = {{Ophthalmology}},
title = {{Age-related macular degeneration is associated with increased proportion of CD56(+) T cells in peripheral blood}},
url = {{http://dx.doi.org/10.1016/j.ophtha.2013.04.014}},
doi = {{10.1016/j.ophtha.2013.04.014}},
volume = {{120}},
year = {{2013}},
}