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Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus

Björck, Lars LU ; Grubb, Anders LU orcid and Kjellén, Lars (1990) In Journal of Virology 64(2). p.941-943
Abstract

Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as... (More)

Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.

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publication status
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keywords
Amino Acid Sequence, Animals, Antiviral Agents/pharmacology, Cell Line, Cerebrospinal Fluid Proteins/pharmacology, Cystatin C, Cystatins/pharmacology, Kinetics, Molecular Sequence Data, Oligopeptides/pharmacology, Simplexvirus/drug effects, Virus Replication/drug effects
in
Journal of Virology
volume
64
issue
2
pages
941 - 943
publisher
American Society for Microbiology
external identifiers
  • pmid:2153254
  • scopus:0025177313
ISSN
0022-538X
DOI
10.1128/JVI.64.2.941-943.1990
language
English
LU publication?
yes
id
a529f66f-596d-4cd9-b435-77b605daa6aa
date added to LUP
2021-10-27 09:39:13
date last changed
2025-10-14 11:06:26
@article{a529f66f-596d-4cd9-b435-77b605daa6aa,
  abstract     = {{<p>Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.</p>}},
  author       = {{Björck, Lars and Grubb, Anders and Kjellén, Lars}},
  issn         = {{0022-538X}},
  keywords     = {{Amino Acid Sequence; Animals; Antiviral Agents/pharmacology; Cell Line; Cerebrospinal Fluid Proteins/pharmacology; Cystatin C; Cystatins/pharmacology; Kinetics; Molecular Sequence Data; Oligopeptides/pharmacology; Simplexvirus/drug effects; Virus Replication/drug effects}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{941--943}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Journal of Virology}},
  title        = {{Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus}},
  url          = {{http://dx.doi.org/10.1128/JVI.64.2.941-943.1990}},
  doi          = {{10.1128/JVI.64.2.941-943.1990}},
  volume       = {{64}},
  year         = {{1990}},
}