Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus
(1990) In Journal of Virology 64(2). p.941-943- Abstract
Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as... (More)
Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.
(Less)
- author
- Björck, Lars LU ; Grubb, Anders LU and Kjellén, Lars
- organization
- publishing date
- 1990
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amino Acid Sequence, Animals, Antiviral Agents/pharmacology, Cell Line, Cerebrospinal Fluid Proteins/pharmacology, Cystatin C, Cystatins/pharmacology, Kinetics, Molecular Sequence Data, Oligopeptides/pharmacology, Simplexvirus/drug effects, Virus Replication/drug effects
- in
- Journal of Virology
- volume
- 64
- issue
- 2
- pages
- 941 - 943
- publisher
- American Society for Microbiology
- external identifiers
-
- scopus:0025177313
- pmid:2153254
- ISSN
- 0022-538X
- DOI
- 10.1128/JVI.64.2.941-943.1990
- language
- English
- LU publication?
- yes
- id
- a529f66f-596d-4cd9-b435-77b605daa6aa
- date added to LUP
- 2021-10-27 09:39:13
- date last changed
- 2024-01-12 02:58:09
@article{a529f66f-596d-4cd9-b435-77b605daa6aa, abstract = {{<p>Cystatin C is a human cysteine proteinase inhibitor present in extracellular fluids. Cystatin C and a tripeptide derivative (Z-LVG-CHN2) that mimics its proteinase-binding center, were tested for possible antiviral activity against herpes simplex virus type 1 (HSV) and poliovirus type 1. Both recombinant cystatin C and Z-LVG-CHN2 displayed strong inhibitory effects on HSV replication, whereas no significant effect on poliovirus replication was seen. The molar concentration of cystatin C that gave total inhibition of HSV replication was lower than that of either Z-LVG-CHN2 or of acyclovir, the drug currently most used against HSV infections. These results suggest that cysteine proteinase inhibitors might play a physiological role as inhibitors of viral replication and that such proteinase inhibitors, or peptide derivatives that mimic their proteinase-binding centers, might be used as antiviral agents.</p>}}, author = {{Björck, Lars and Grubb, Anders and Kjellén, Lars}}, issn = {{0022-538X}}, keywords = {{Amino Acid Sequence; Animals; Antiviral Agents/pharmacology; Cell Line; Cerebrospinal Fluid Proteins/pharmacology; Cystatin C; Cystatins/pharmacology; Kinetics; Molecular Sequence Data; Oligopeptides/pharmacology; Simplexvirus/drug effects; Virus Replication/drug effects}}, language = {{eng}}, number = {{2}}, pages = {{941--943}}, publisher = {{American Society for Microbiology}}, series = {{Journal of Virology}}, title = {{Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus}}, url = {{http://dx.doi.org/10.1128/JVI.64.2.941-943.1990}}, doi = {{10.1128/JVI.64.2.941-943.1990}}, volume = {{64}}, year = {{1990}}, }